Uterine Smooth Muscle: Electrophysiology and Pharmacology

  • J. Mironneau
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 111)


In the myometrium, an increase in the concentration of the free calcium in the cytoplasm is essential for the initiation of contraction. Calcium can enter the cell through plasma membrane channels activated either by membrane depolarization or by specific binding of a ligand to its receptor. In addition, calcium may be released from stores within the cell in response to activation of membrane receptors. The link between these two events is the breakdown of plasma membrane phosphoinositides with the generation of second messengers. This chapter focuses on the different ion channels present in myometrial cells and how they are modulated during gestation and in response to endogenous hormones that are known to influence uterine motility.


Sarcoplasmic Reticulum Myosin Light Chain Kinase Calcium Entry Blocker Intracellular Calcium Store Uterine Smooth Muscle 
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