New Aspects in the Treatment of Chronic Lymphocytic Leukemia

  • J. L. Binet
  • the French Cooperative Group on CLL
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)


For new aspects in the treatment of chronic lymphocytic leukemia are discussed: rationale for selection of patients for treatment, results of new drugs, auto and allogeneic bone marrow transplantation and response criteria to treatment.


Chronic Lymphocytic Leukemia Bone Marrow Transplantation Allogeneic Bone Marrow Transplantation Remission Status Cytic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Rai, K., Sawitsky, A., Cronkite, E., Chanana, A.B., Levy, R.N. and Pasternack, B.S. Clinical staging of chronic lymphocytic leukemia. Blood, 46, 219–234, 1975PubMedGoogle Scholar
  2. 2.
    Binet, J.L., Auquier, A., Dighiero, G., Chastang, C, Piguet, H., Goasguen, J., Vaugier, G., Potron, G., Colona, P., Thomas, M., Tchernia, G., Jacquillat, C., Boivin, P., Lesty, C., Duault, M.T. and Montconduit, M. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer, 48, 198–206, 1981PubMedCrossRefGoogle Scholar
  3. 3.
    Keating, M.J., Kantarjian, M., Redman, J., Koller, C, Barlogie, B., Velasquez, W., Plunkett, W., Freireich, E.J., McCredie, K.B. Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood, 74, 19–25, 1989PubMedGoogle Scholar
  4. 4.
    Keating, M.J. Fludarabine phosphate in the treatment of chronic lymphocytic leukemia. Seminars in Oncology, 17 (suppl 8), 49–55, 1990PubMedGoogle Scholar
  5. 5.
    Grever, M.R., Kopecky, K.J., Coltman, C.A., Files, J.C. Greenberg, B.R., Hutton, J.J., Talley, R., Von Hoff, D.D., Balcerzak, S.P. Fludarabine monophosphate: a potentially useful agent in chronic lymphocytic leukemia. Nouv Rev Fr Hematol, 80, 457–460, 1988Google Scholar
  6. 6.
    Dillman, R.O., Mick, R. and McIntyre, O.K. Pentostatin in chronic lymphocytic leukemia: a phase II trial of cancer and leukemia group. B J Clin Oncol, 7, 433–439, 1989Google Scholar
  7. 7.
    Piro, L.D., Carrera, C.J., Beutler, E. and Carson, D.A. Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia. Blood, 72, 1069–1073, 1988PubMedGoogle Scholar
  8. 8.
    Michallet, M., Corront, B., Grathwohl, A., Milpied, N., Dauriac, C, Brunet, S., Soler, J., Jouet, J.P., Esperou Bourdeau, H., Arcese, W., Witz, F., Moine, A. and Zwaan, F.E. ( ) Allogeneic bone marrow transplantation in chronic lymphocytic leukemia: 17 cases. Bone Marrow Transplantation, (in press)Google Scholar
  9. 9.
    Rabinowe, S.N., Soiffer, R.J., Gribben, J.G., Freedman, A.S., Pesek, K.W., Daley, H.L., Daley, J.F., Spector, N.L., Anderson, K.C., Robertson, M.J., Ritz, J. and Nadler, L.M. Autologous and allogeneic bone marrow transplantation (BMT) for patients with Binet stage B and C B-cell chronic lymphocytic leukemia (B-CLL). Blood, 80, 170a, 1992Google Scholar
  10. 10.
    Khouri, I., Thomas, M., Andersson, B., Deisseroth, A., Keating, M., Champlin, R. Purged autologous bone marrow transplantation for chronic lymphocytic leukemia: preliminary results. Blood, 80, 66a, 1992Google Scholar
  11. 11.
    Sutton, L., Boccaccio, C, Gabarre, J., Maloum, K., Ben-Othman, T., Soussain, C, Cosset, JM., Merle-Béral, H., Binet, JL., Leblond, V. Intensification thérapeutique par chimiothérapie suivie d’auto-greffe dans les leucémies lymphoides chroniques réfractaries. Nouv Rev Fr Hématol, 36, 104, 1994Google Scholar
  12. 12.
    International Workshop on chronic lymphocytic leukemia. Chronic lymphocytic leukemia: recommendations for diagnosis, staging and response criteria. Ann Inter Med, 110, 236–237, 1989Google Scholar
  13. 13.
    Pangalis, G.A. and Griva, E. Recombinant alpha-interferon in untreated stages A and B chronic lymphocytic leukemia: a preliminary report. Cancer, 61, 869–872, 1988PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. L. Binet
    • 1
  • the French Cooperative Group on CLL
    • 1
  1. 1.Department of HematologyGroupe Hospitalier Pitie-SalpetriereParisFrance

Personalised recommendations