Targeted Drug Therapy in Childhood Acute Lymphoblastic Leukemia

  • Mary V. Relling
  • Ching-Hon Pui
  • William E. Evans
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)


Pediatric acute lymphoblastic leukemia (ALL) is one of the most drug-responsive cancers, with approximately 70% of children being cured with chemotherapy alone (Pui and Crist, 1994). Focussing on the collective good responsiveness, however, may obscure the fact that there remain children who are not cured, and there are children who experience excessive toxicity from regimens that are well tolerated by the majority of children. Of the many factors that can affect how an individual responds to a particular ALL treatment regimen, one factor may be variability in the pharmacokinetics of antineoplastic agents. We describe herein our studies of whether overall clinical outcome is related to pharmacokinetic variability.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Systemic Exposure Conventional Dose Childhood Acute Lymphoblastic Leukemia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Mary V. Relling
    • 1
  • Ching-Hon Pui
    • 1
  • William E. Evans
    • 1
  1. 1.St. Jude Children’s Research Hospital and Colleges of Pharmacy and MedicineUniversity of TennesseeMemphisUSA

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