Recombinant Human Erythropoietin After Bone Marrow Transplantation — A Placebo Controlled Trial

  • H. Link
  • M. A. Boogaerts
  • A. Fauser
  • R. Or
  • J. Reiffers
  • N. C. Gorin
  • A. Carella
  • F. Mandelli
  • S. Burdach
  • A. Ferrant
  • W. Linkesch
  • S. Tura
  • A. Bacigalupo
  • F. Schindel
  • H. Heinrichs
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)

Abstract

Several historically controlled studies [1,3,5] and one small open prospective randomized trial [4] showed an acceleration of erythropoietic recon-stitution after allogeneic bone marrow transplantation (BMT). Some authors claimed a stimulatory effect on thrombopoiesis after BMT [2,4]. This double-blind, placebo-controlled randomized trial was conceived to analyze the impact of rHu EPO on regeneration of erythro-poiesis after allogeneic or autologous bone marrow transplantation.

Keywords

Placebo Leukemia Erythropoietin Erythro 

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References

  1. 1.
    Link H, Brune T, Hübner G, et al. Effect of recombinant human erythropoietin after bone marrow transplantation. Ann Hematol. 1993, 67: 169–179.PubMedCrossRefGoogle Scholar
  2. 2.
    Locatelli F, Zecca M, Beguin Y, et al. Accelerated erythroid repopulation with no stem-cell competition effect in children treated with recombinant human erythropoietin after allogeneic bone marrow transplantation. Br J Haematol 1993; 84: 752–754.PubMedCrossRefGoogle Scholar
  3. 3.
    Mitus AJ, Antin JH, Rutherford CJ, et al. Significant reduction in homologous red cell transfusion requirements with the use of recombinant human erythropoietin in allogeneic bone marrow transplantation. Blood 1992, 80, (Suppl. 1) 330aGoogle Scholar
  4. 4.
    Stegmann JL, Lopez J, Otero JM, et al. Erythropoietin treatment in allogeneic BMT accelerates erythroid reconstitution: results of a prospective controlled randomized trial. Bone Marrow Transplant. 1992, 10: 541–546.Google Scholar
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    Vannucchi AM et al. Stimulation or erythroid engraftment by recombinant human erythropoietin ABO-compatible, HLA-identical, allogeneic bone marrow transplant patients. Leukemia 1992, 6: 215–219.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Link
    • 1
  • M. A. Boogaerts
    • 1
  • A. Fauser
    • 1
  • R. Or
    • 1
  • J. Reiffers
    • 1
  • N. C. Gorin
    • 1
  • A. Carella
    • 1
  • F. Mandelli
    • 1
  • S. Burdach
    • 1
  • A. Ferrant
    • 1
  • W. Linkesch
    • 1
  • S. Tura
    • 1
  • A. Bacigalupo
    • 1
  • F. Schindel
    • 1
  • H. Heinrichs
    • 1
  1. 1.Department of Haematology and OncologyMedizinische Hochschule HannoverGermany

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