Is There a Role for Interleukin-2 Gene Transfer in the Management of Acute Leukemia?
The limitations encountered with the administration of high dose exogenous interleukin-2 (IL-2) have triggered the search for alternative immunotherapeutic approaches or delivery modalities. Studies carried out in experimental tumor models suggest that the tumor-genic potential can be reversed following transduction of different cytokine genes into the DNA of the neoplastic cells. Transfer of the IL-2 gene has also been associated with the generation of anti-tumor specificity and anti-tumor memory. These findings have led to the activation of the first clinical vaccination protocols with human tumor cells engineered to release IL-2 in patients suffering from different tumors. Here, we shall report on the feasability of inserting the IL-2 gene into human acute leukemia cells and the possibility of using this approach for the management of patients with acute leukemia.
KeywordsToxicity Europe Lymphoma Leukemia Adenocarcinoma
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