Abstract
Between June 1987 and April 1993, 147 children aged from 2–18 years (47 girls and 100 boys) with first relapse of acute lymphoblastic leukemia were included to the study. The children were treated according to the BFM 85 ALL relapse protocol. There were 91 cases with early and 56 cases with late relapse (BM-72, local-50, combined-22, others-3). The probability of EFS were calculated according to Kaplan-Meier method. The overall second complete remission (CR) rate in early relapse was 79.12% and in late relapse 85.71%. The probability of overall event free survival (EFS) after 6 years was 25.52%. The EFS achieved in children with late relapses was four times higher when compared with early relapses 46.55% vs. 11.47% (p = 0.05).
The results obtained with BFM 85 chemotherapy in children with first late relapse are acceptable. For children with early relapses, other chemotheraphy methods together with BMT in second remission should be introduced.
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References
Alarcon PA, Trigg ME, Giller ME, Rumelhardt Holida M, Wen B (1990): Bone marrow transplantation improves survival for children with acute lymphoblastic leukemia in relapse. Am. J. Ped. Hematol/Oncol, 12, 468–471
Behrendt H, Leeuven E Schurwirth C, Verkes R, Hermans J, Does van der Berg, Wering ER (1990): Bone marrow relapse occurring as first relapse in children with acute lymphoblastic leukemia Med. Oed. Oncol., 18, 190–196
Belasco JB, Luery N, Scher Ch (1990): Multiagent chemotherapy in relapsed acute lymphoblastic leukemia in children. Cancer 66, 2492–2497
Brisco MJ, Condon J, Hughes E, Neoh SH, Sykes PJ, Seshadri R, Toogood I, Waters K, Tauro G, Ekert H, Morley AA (1994): Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction. The Lancet, 343, 196–199
Boguslawska-Jaworska J, Chybicka A, Kazanowska B, Pietras W, Armata J, Balwierz W, Bubala H, Jackowska T, Koehler T, Michalewska D, Ochocka M, Radwanska U, Rokicka-Milewska R, Rytlewska M, Skomra S, Œladkowska G, Zelenay E (1990): The results of ALL relapses treatment according to BFM protocol in experience of the polish children‘s leukemia/lymphoma study group. Prac. Nauk. A.M., Suppl. 88–95
Butturini A (1987) Which treatment for childhood acute lymphoblastic leukemia in second remission? Lancet, 429–432
Culbert J, Schuster J, Land VJ, Wharam D, Thomas Rm, Nitschke R, Pinkel D, Vietti T (1991): Remission induction and continuation therapy in children with their first relapse of acute lymphoblastic leukemia. Cancer, 67, 37–42
Falleta JM, Schuster JJ, Crist WM, Pullen J, Bortowitz MJ, Wharam M, Patterson R, Foreman E, Vietti TJ (1992): Different patterns of relapse associated with three intensive treatment regiments for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Study Group. Leukemia, 6, 541–546
Finkelstein J, Miller D, Feusner J, Stram D, Baum E, Shina D, Johnson D, Gyepes M, Hammond D (1994): Treatment of overt isolated testicular relapse in children on therapy for acute lymphoblastic leukemia. Cancer, 73, 219–223
Gale RP, Simone JV, Hoelzer D, Frei E (1991): Curing leukemia. Leukemia, 5, 632–635
Henze G (1991): 6-year experience with comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ. BFM 85). A relapse study of BFM Group. Blood 78, 1166–1292
Kaplan EL, Meier P (1958): Non parametric estimation from incomplete observations. J. Am. Stat. 53, 457–466
Pui Ch, Bowman P, Ochs J, Dodge RK, Riviera G (1988): Cyclic combination chemotherapy for acute lymphoblastic leukemia recurring after elective cessation of therapy. Med. Ped. Oncol. 16, 21–26
Riehm H (1986): Treatment protocol ALL BFM-83. Klin. Pediatr., 199, 151–160
Riviera GK, Santana V, Mahmoud H, Buchanan G, Crist WM (1989): Acute lymphoblastic leukemia of childhood: the problem of relapses. BMT, 4, 80–85
Sauerbrey A, Zintl F, Malke H, Reimann M, Maaser M, Domula M, Dorffel W, Eggers G, Exadaktylos P Kotte W (1993): Results and experiences with a modified BFM protocol for treatment of recurrence in children with acute lymphoblastic leukemia in East German areas. Klin. Padiatr., 205, 281–287. Cancer, 73, 219–223
Steinhertz P, (1989): Reinduction therapy for advanced or refractory acute lymphoblastic leukemia of childhood Cancer 63, 1472–1476
Uderzo C, Zurlo MG, Adamoli L, Zanesco L, Calculi A, Comelli A, Montemezemolo L. Di Tulio M, Guazelli C, Donfrancesco A, Werner B (1990): Treatment of isolated testicular relapse in childhood acute lymphoblastic leukemia: An Italian Multicenter Study. J Clin Oncol, 8, 672–677
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© 1996 Springer-Verlag Berlin Heidelberg
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Boguslawska-Jaworska, J. et al. (1996). Six Years’ Experience with Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group. In: Hiddemann, W., et al. Acute Leukemias V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78907-6_42
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DOI: https://doi.org/10.1007/978-3-642-78907-6_42
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