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Six Years’ Experience with Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group

  • J. Boguslawska-Jaworska
  • A. Chybicka
  • J. Armata
  • W. Balwierz
  • H. Bubala
  • B. Filiks-Litwin
  • J. Kowalczyk
  • D. Lukowska
  • M. Ochocka
  • U. Radwanska
  • R. Rokicka-Milewska
  • D. Sonta-Jakimczyk
  • W. Stronjny
  • E. Zelenay
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)

Abstract

Between June 1987 and April 1993, 147 children aged from 2–18 years (47 girls and 100 boys) with first relapse of acute lymphoblastic leukemia were included to the study. The children were treated according to the BFM 85 ALL relapse protocol. There were 91 cases with early and 56 cases with late relapse (BM-72, local-50, combined-22, others-3). The probability of EFS were calculated according to Kaplan-Meier method. The overall second complete remission (CR) rate in early relapse was 79.12% and in late relapse 85.71%. The probability of overall event free survival (EFS) after 6 years was 25.52%. The EFS achieved in children with late relapses was four times higher when compared with early relapses 46.55% vs. 11.47% (p = 0.05).

The results obtained with BFM 85 chemotherapy in children with first late relapse are acceptable. For children with early relapses, other chemotheraphy methods together with BMT in second remission should be introduced.

Keywords

Complete Remission Acute Lymphoblastic Leukemia Early Relapse Event Free Survival Late Relapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. Boguslawska-Jaworska
    • 7
  • A. Chybicka
    • 7
  • J. Armata
    • 1
  • W. Balwierz
    • 1
  • H. Bubala
    • 4
  • B. Filiks-Litwin
    • 2
  • J. Kowalczyk
    • 2
  • D. Lukowska
    • 4
  • M. Ochocka
    • 5
  • U. Radwanska
    • 3
  • R. Rokicka-Milewska
    • 4
  • D. Sonta-Jakimczyk
    • 6
  • W. Stronjny
    • 4
  • E. Zelenay
    • 4
  1. 1.Department of Children Hematology, Polish American Children’s HospitalM. Copernicus Institute of PediatricsKrakowPoland
  2. 2.Department of Children HematologyInstitute of Pediatrics, Faculty of MedicineLublinPoland
  3. 3.Department of Children Hematology and Oncology, Faculty of MedicinePoznañPoland
  4. 4.Department of Children Hematology and Oncology, Faculty of MedicineWarsawPoland
  5. 5.Department of Children Hematology, Faculty of MedicineWarsawPoland
  6. 6.Department of Children Hematology and Oncology, Faculty of MedicineZabrzePoland
  7. 7.Department of Children Hematology and Oncology, Faculty of MedicineWroclawPoland

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