Six Years’ Experience with Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group
Between June 1987 and April 1993, 147 children aged from 2–18 years (47 girls and 100 boys) with first relapse of acute lymphoblastic leukemia were included to the study. The children were treated according to the BFM 85 ALL relapse protocol. There were 91 cases with early and 56 cases with late relapse (BM-72, local-50, combined-22, others-3). The probability of EFS were calculated according to Kaplan-Meier method. The overall second complete remission (CR) rate in early relapse was 79.12% and in late relapse 85.71%. The probability of overall event free survival (EFS) after 6 years was 25.52%. The EFS achieved in children with late relapses was four times higher when compared with early relapses 46.55% vs. 11.47% (p = 0.05).
The results obtained with BFM 85 chemotherapy in children with first late relapse are acceptable. For children with early relapses, other chemotheraphy methods together with BMT in second remission should be introduced.
KeywordsLeukemia Oncol Methotrexate Meningitis Prednisone
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