Hematopoietic Recovery and Priming — Therapeutic Effects of GM-CSF in the Treatment of AML
After a first study showed that GM-CSF following chemotherapy effectively accelerated neutrophil recovery and reduced early mortality in high risk patients with AML, a second study was begun in which GM-CSF was applied preceeding chemotherapy and continuing until neutrophil recovery in the initial 5 chemotherapy courses for patients with newly diagnosed AML. The CR rate in patients of 16–75 (median 50) years is 79% in GM-CSF patients and 82% in controls. GM-CSF patients showed a trend to more frequent rapid blast clearance and fewer persistent leukemias and — in patients under age 60 — a significantly superior remission duration as of this update. It should be shown later by this study whether GM-CSF multiple course priming and longterm administration adds to the cure rate of patients with AML.
KeywordsPlacebo Toxicity Leukemia Neutropenia Cytosine
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