CD34 and CD38 Expression on Blasts in Myelodysplastic Syndromes and Secondary AML

  • W. Verbeek
  • C. Ries
  • D. Grove
  • M. Unterhalt
  • W. Hiddemann
  • B. Wörmann
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)

Abstract

The expression of a “stem cell like” blast immunophenotype (CD34+/CD38−) has been associated with a poor prognosis in AML. Advanced myelodysplastic syndromes and secondary AML’s are another patient population with an inferior prognosis. We hypothesized that a stem cell origin of these disorders results in a higher incidence of a CD34+/CD38− blast immunophenotype. This could be biologically related to a higher chemoresistence. The data presented here shows that a “stem cell like” blast immunophenotype is rare in RAEB. In addition there is no significant difference between primary AML and secondary AML or RAEB-T.

Keywords

Argon Leukemia Peri Sorting FITC 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • W. Verbeek
    • 1
  • C. Ries
    • 1
  • D. Grove
    • 1
  • M. Unterhalt
    • 1
  • W. Hiddemann
    • 1
  • B. Wörmann
    • 1
  1. 1.Department of Hematology and OncologyUniversity of GöttingenGöttingenGermany

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