Abstract
The expression of a “stem cell like” blast immunophenotype (CD34+/CD38−) has been associated with a poor prognosis in AML. Advanced myelodysplastic syndromes and secondary AML’s are another patient population with an inferior prognosis. We hypothesized that a stem cell origin of these disorders results in a higher incidence of a CD34+/CD38− blast immunophenotype. This could be biologically related to a higher chemoresistence. The data presented here shows that a “stem cell like” blast immunophenotype is rare in RAEB. In addition there is no significant difference between primary AML and secondary AML or RAEB-T.
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© 1996 Springer-Verlag Berlin Heidelberg
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Verbeek, W., Ries, C., Grove, D., Unterhalt, M., Hiddemann, W., Wörmann, B. (1996). CD34 and CD38 Expression on Blasts in Myelodysplastic Syndromes and Secondary AML. In: Hiddemann, W., et al. Acute Leukemias V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78907-6_2
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DOI: https://doi.org/10.1007/978-3-642-78907-6_2
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