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CD34 and CD38 Expression on Blasts in Myelodysplastic Syndromes and Secondary AML

  • W. Verbeek
  • C. Ries
  • D. Grove
  • M. Unterhalt
  • W. Hiddemann
  • B. Wörmann
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)

Abstract

The expression of a “stem cell like” blast immunophenotype (CD34+/CD38−) has been associated with a poor prognosis in AML. Advanced myelodysplastic syndromes and secondary AML’s are another patient population with an inferior prognosis. We hypothesized that a stem cell origin of these disorders results in a higher incidence of a CD34+/CD38− blast immunophenotype. This could be biologically related to a higher chemoresistence. The data presented here shows that a “stem cell like” blast immunophenotype is rare in RAEB. In addition there is no significant difference between primary AML and secondary AML or RAEB-T.

Keywords

Acute Myeloid Leukemia Myelodysplastic Syndrome Hematopoietic Progenitor Cell Leukemic Blast Inferior Prognosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • W. Verbeek
    • 1
  • C. Ries
    • 1
  • D. Grove
    • 1
  • M. Unterhalt
    • 1
  • W. Hiddemann
    • 1
  • B. Wörmann
    • 1
  1. 1.Department of Hematology and OncologyUniversity of GöttingenGöttingenGermany

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