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Synergism and Adaptive Response in the Interaction of Low Dose Irradiation with Subsequent Mutagenic Treatment in G2 Phase Human Lymphocytes

  • G. Olivieri
  • A. Bosi
  • R. Grillo
  • B. Salone

Abstract

Radiobiological dose effects at higher dose and dose-rate levels are satisfactorily elucidated; the radiobiological effects at very low radiation doses and dose rates, however, still remain ambiguous (Pohl-Rüling 1990; Sagan 1987). The study of interaction of low dose irradiation with subsequent mutagenic treatment could be a way of evaluating the effects of low doses of irradiation. This type of research has linked to a general biological phenomenon in which the cells actually sense environmental adversity mostly through the exposure to low doses and then respond to the various types of stress by means of a change in gene expression (Demple 1991; Lindquist 1986; Scandalios 1990; Shevell et al. 1990). On this respect there is now a considerable body of evidence showing that exposure of cells to very low doses of ionizing radiation can “adapt” them such that they show a reduced response to a subsequent higher dose. The initial dose may protect by inducing or priming a repair mechanism. This so called “adaptive response” has been demonstrated by numerous authors using different materials and different end points (for reviews, see Kelsey et al. 1991; Liu et al. 1992; Luckey 1991; Oftedal 1991; Olivieri and Bosi 1990; Rieger et al. 1992; Shadley and Dai 1992 a, b; Wolff et al. 1990). Nevertheless many results remain equivocal (for reviews, see Hain et al. 1992; Müller et al. 1992; Wojcik et al. 1992). Moreover using human lymphocytes has been reported that low doses of ionizing radiation, which usually lead to a decrease in the damage caused by subsequent exposure may also interact synergistically with mutagenic treatment.

Keywords

Adaptive Response Human Lymphocyte Challenging Dose Mutagenic Treatment Synergistic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • G. Olivieri
    • 1
  • A. Bosi
    • 1
  • R. Grillo
    • 1
  • B. Salone
    • 1
  1. 1.Dept. of GeneticsMolecular Biology Università “La Sapienza”RomeItaly

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