Abstract
Interferons were first discovered in 1957 by Isaacs and Lindenmann [1]. They are proteins produced by cells in response to virus infection, and they can confer resistance to attack by a wide range of viruses in a species-specific way. As soon as their importance in the regulation of immune responses as well as their involvement in the control of cell growth and differentiation had been recognised, the possibility of growth inhibition in cancer was suggested. Following the successful cloning of the interferon genes, in 1982 the first recombinant human interferons were produced on a commercial scale, allowing extensive research during the last ten years.
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References
Isaacs A, Lindenmann J: Virus interference. I. The interferon. Proceedings of the Royal Society of London (Series B) 1957: 259–267
Horoszewicz JS, Murphy GP: An assessment of the current use of human interferons in therapy of urologica! cancers. J Urol 1989 (142): 1173–1180
Rubinstein M, Orchansky P: The interferon receptors. CRC Critical Reviews in Biochemistry 1986 (21): 249–275
Balkwill FR: Side-effects of interferon therapy. In: Balkwill FR (ed) Cytokines in Cancer Therapy. Oxford University Press, New York 1989 pp 44–45
Kurzrock R, Quesada JR, Rosenblum MG, Sherwin SA, Gutterman JU: Phase I study of i.v. administered γ interferon in cancer patients. Cancer Treatment Reports 1986 (70): 1357–1363
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© 1994 Springer-Verlag Berlin Heidelberg
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Pummer, K. (1994). Introduction. In: Pummer, K. (eds) Biological Modulation of Solid Tumours by Interferons. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78866-6_1
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DOI: https://doi.org/10.1007/978-3-642-78866-6_1
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