Determinants of mRNA Stability in Higher Plants
In eukaryotes, each of the steps between transcription of a gene and degradation of the corresponding protein are potential targets for regulation of expression. Of these, transcriptional control mechanisms are the best understood, both from the perspective of basic components of the transcriptional apparatus, and with respect to the mechanisms that regulate specific genes or sets of genes. However, it has become apparent that many eukaryotic genes are controlled to some extent by posttranscriptional events (Peltz et al., 1991). The contribution of mRNA processing, transport, and stability, and of translational and post-translational mechanisms to the regulation of gene expression has therefore received increasing attention recently. Of these, regulation at the level of mRNA stability is among the most widely evoked, but the mechanisms by which such control is exerted remain poorly understood.
KeywordsEstrogen Hunt Stein Aspergillus Chloramphenicol
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