Identification and Characterization of Novel ATP-Binding Cassette Proteins in Saccharomyces Cerevisiae

  • Jonathan Leighton
Conference paper
Part of the NATO ASI Series book series (volume 82)


In recent years, a great deal of work has been focused on elucidating the mechanism by which nuclear-encoded proteins are imported into mitochondria from the cytoplasm (Glick and Schatz, 1991; Wienhues and Neupert, 1992). In contrast, despite some reports in the literature of effects of mitochondrial mutations on nuclear gene transcription, very little is known about how mitochondria communicate with the nucleus and how such signals might be transmitted (Forsburg and Guarente, 1989). Since members of the rapidly growing superfamily of transport proteins known as ATP-Binding Cassette (ABC) transporters appear to be present in all organisms (Higgins, 1992), we asked whether such transporters might also exist in mitochondria and play an as yet undiscovered role in communication with the nucleus or, more generally, in transport of substrates across the mitochondrial membranes.


Cystic Fibrosis Transmembrane Regulator Zellweger Syndrome Degenerate Oligonucleotide Primer Peroxisomal Membrane Protein Cell BioI 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Jonathan Leighton
    • 1
  1. 1.Department of Biochemistry BiocenterUniversity of BaselBaselSwitzerland

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