Skip to main content

Assembly of Sphingolipids into Membranes of the Yeast, Saccharomyces Cerevisiae

  • Conference paper
Biological Membranes: Structure, Biogenesis and Dynamics

Part of the book series: NATO ASI Series ((ASIH,volume 82))

Abstract

In the lower eukaryote, Saccharomyces cerevisiae,the inositol-containing ceramides inositolphosphate ceramide (IPC), mannosyl inositolphosphate ceramide (MIPC) and mannosyl diinositolphosphate ceramide (M(IP)2C) were shown to be the major sphingolipids (Wagner & Zofcsik, 1966; Steiner et al., 1969; Smith & Lester, 1974).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aalto, M.K., Ruohonen, L., Hosono, K. and Keränen, S. (1991) Cloning and sequencing of the yeast Saccharomyces cerevisiae SEC1 gene localized in chromosome IV. Yeast 7, 643–650

    Article  PubMed  CAS  Google Scholar 

  • Angus, W.W. and Lester, R.L. (1972) Turnover of inositol and phosphorus containing lipids in Saccharomyces cerevisiae; extracellular accumulation of glycerophosphorylinositol derived from phosphatidylinositol. Arch. Biochem. Biophys. 151, 483–495

    Article  PubMed  CAS  Google Scholar 

  • Becker, G.W. and Lester, R.L. (1980) Biosynthesis of phosphoinositol-containing sphingolipids from phosphatidylinositol by a membrane preparation from Saccharomyces cerevisiae. J. Bacteriol. 142, 747–754

    PubMed  CAS  Google Scholar 

  • Broekhuyse, R.M. (1968) Phospholipids in tissues of the eye. Biochim. Biophys. Acta 152, 307–315

    PubMed  CAS  Google Scholar 

  • Heller, L., Orlean, P. and Adair, W.L., Jr. (1992) Saccharomyces cerevisiae sec 59 cells are deficient in dolichol kinase activity. Proc. Natl. Acad. Sci., USA, 89, 7013–7016

    Article  PubMed  CAS  Google Scholar 

  • Kepes, F. and Schekman, R. (1988) The yeast SEC53 gene encodes phosphomannomutase. J. Biol. Chem. 263, 9155–9166

    PubMed  CAS  Google Scholar 

  • Klig, L.S., Homann, M.J., Carman, G.M. and Henry, S.A. (1985) Coordinate regulation of phospholipid biosynthesis in Saccharomyces cerevisiae: Pleiotropically constitutive opil mutant. J. Bacteriol. 162, 1135–1141

    PubMed  CAS  Google Scholar 

  • Lowry, O.H., Rosebrough, A.L., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265–275

    PubMed  CAS  Google Scholar 

  • Patton, J.L. and Lester, R.L. (1991) The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane. J. Bacteriol. 173, 3101–3108.

    PubMed  CAS  Google Scholar 

  • Pryer, N.K., Wuestehube, L.J. and Schekman, R. (1992) Vesicle-mediated protein sorting. Ann. Rev. Biochem. 61, 471–516

    Article  PubMed  CAS  Google Scholar 

  • Puoti, A., Desponds, C. and Conzelmann, A. (1991) Biosynthesis of mannosylinositolphosphoceramide in Saccharomyces cerevisiae is dependent on genes controlling the flow of secretory vesicles from the endoplasmic reticulum to the Golgi. J. Cell. Biol. 113, 515–525

    Article  PubMed  CAS  Google Scholar 

  • Schekman, R. (1985) Protein localization and membrane traffic in yeast. Ann. Rev. Cell Biol. 1, 167–195

    Article  Google Scholar 

  • Smith, M.S. and Lester, R.L. (1974) Inositolphosphorylceramide, a novel substance and a chief member of a major group of yeast sphingolipids containing a single inositol phosphate. J. Biol. Chem. 249, 3395–3405

    PubMed  CAS  Google Scholar 

  • Steiner, S., Smith, S., Waechter, C.J. and Lester, R.L. (1969) Isolation and partial characterization of a major inositol-containing lipid in baker’s yeast, mannosyl-diinositol diphosphoryl-ceramide. Proc. Natl. Acad. Sci., USA, 64, 1042–1048

    Article  PubMed  CAS  Google Scholar 

  • Wagner, H. and Zofcsik, W. (1966) Sphingolipide und Glykolipide von Pilzen und höheren Pflanzen. II. Isolierung eines Sphingoglykolipids aus Candida utilis und Saccharomyces cerevisiae. Biochem. Z. 346, 343–350

    Google Scholar 

  • Zinser, E., Sperka-Gottlieb, C.D.M., Fasch, E.-V., Kohlwein, S.D., Paltauf, F. and Daum, G. (1991) Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eucaryote Saccharomyces cerevisiae. J. Bacteriol. 173, 2026–2034

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hechtberger, P., Zinser, E., Paltauf, F., Daum, G. (1994). Assembly of Sphingolipids into Membranes of the Yeast, Saccharomyces Cerevisiae. In: Op den Kamp, J.A.F. (eds) Biological Membranes: Structure, Biogenesis and Dynamics. NATO ASI Series, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78846-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78846-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78848-2

  • Online ISBN: 978-3-642-78846-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics