The Pore-Forming Toxin Aerolysin: From the Soluble to a Transmembrane Form
Bacterial pore forming toxins are an interesting model to study protein-membrane interactions including post translational insertion of proteins into membranes. These toxins have the remarkable feature of existing in two states either a water soluble form, which is secreted by the producing cell and can diffuse towards the target cell, and a membrane-bound form which forms the final transmembrane pore. This change in environment most certainly implies a major conformational change in the protein. Different types of protein seem to cope with this problem in different ways.
KeywordsAeromonas Hydrophila Hydrophobic Patch Alpha Toxin Major Conformational Change Dime Dissociation
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