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Biological Membranes: Structure, Biogenesis and Dynamics pp 155–167Cite as

Co-translational Modification, Stability and Turnover of Eukaryotic Proteins

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Part of the book series: NATO ASI Series ((ASIH,volume 82))

Abstract

Eukaryotic function is tightly controlled through the complex mechanisms that regulate transcriptional and translational events. These processes are variously augmented by co- and post-translational modifications that affect function, location and ultimately turnover for each protein. Among the least well understood aspects are stability, including the process of folding, and degradation of both normal and damaged proteins. Since proteolytic destruction of proteins is as important as synthesis in determining the level of a biological activity, it represents a major cellular activity whose dissection is essential for the full appreciation of the regulation of eukaryotic cell function.

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Author information

Author notes

  1. Richard L. Kendall

    Present address: Department of Biochemistry, Merck Research Laboratories, Rahway, NJ, 07065, USA

  2. Hubert Hondermarck

    Present address: Laboratoire de Biologie du Developpement, Universite de Lille 1, 59655, Villeneuve d’Ascq cedex, France

Authors and Affiliations

  1. Department of Biological Chemistry, College of Medicine, University of California, Irvine, Irvine, California, 92715-1700, USA

    Ralph A. Bradshaw, Jose Sy, Albert E. Stewart, Richard L. Kendall, Hubert Hondermarck & Stuart M. Arfin

  2. Department of Chemistry, CSU Fresno, Fresno, CA, 92740, USA

    Jose Sy

Authors
  1. Ralph A. Bradshaw
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  2. Jose Sy
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  3. Albert E. Stewart
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  4. Richard L. Kendall
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  5. Hubert Hondermarck
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  6. Stuart M. Arfin
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Editor information

Editors and Affiliations

  1. Centre for Biomembranes and Lipid Enzymology, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    Jos A. F. Op den Kamp

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© 1994 Springer-Verlag Berlin Heidelberg

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Bradshaw, R.A., Sy, J., Stewart, A.E., Kendall, R.L., Hondermarck, H., Arfin, S.M. (1994). Co-translational Modification, Stability and Turnover of Eukaryotic Proteins. In: Op den Kamp, J.A.F. (eds) Biological Membranes: Structure, Biogenesis and Dynamics. NATO ASI Series, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78846-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-78846-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78848-2

  • Online ISBN: 978-3-642-78846-8

  • eBook Packages: Springer Book Archive

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