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Das Zervixkarzinom. Gegenwärtiger Stand und neue Aspekte der systemischen Therapie

  • Chapter
Immuntherapie in der gynäkologischen Onkologie

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Zusammenfassung

Inzidenz und Letalität des Zervixkarzinoms variieren beträchtlich und sind beispielsweise sehr hoch in Zentral- und Südamerika, aber niedrig in den Vereinigten Staaten und Westeuropa (Petitti u. Porterfield 1992). In Ländern der Europäischen Gemeinschaft beträgt die durchschnittliche Letalität 13,6 pro 100000 für Frauen im Alter von 45–65 Jahren, für Frauen ≧ 65 Jahre ist sie 25,9 pro 100000 (Moller-Jensen et al. 1990). Nach Schätzungen der „American Cancer Society“zählte man 1990 in den USA 13 500 Frauen mit fortgeschrittenem Zervixkarzinom, welches bei 6000 Fällen die Todesursache war (Carlson 1990). Bei Patientinnen mit fortgeschrittener Erkrankung hat sich die Fünfjahresheilung zwischen 1950 und 1981 nicht verbessert (Boronow 1991). Zervixkarzinome sind histologisch mehrheitlich vom Plattenepitheltypus. Die Prävalenz des Adenokarzinoms scheint jedoch zuzunehmen, und heute gehören rund 20% der invasiven Zervixkarzinome zu diesem Typus (Goodman et al. 1989). Jüngere Frauen mit Zervixkarzinom haben einen höheren Anteil an Adenokarzinomen (Angel et al. 1992; Brand et al. 1988; Kushtagi u. Rao 1991).

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  1. E. E. Holdener
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  2. G. Massimini
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  1. Universitäts-Frauenklinik, Voßstraße 9, 69115, Heidelberg, Deutschland

    G. Bastert  & D. Wallwiener  & 

  2. Hoffmann-La Roche AG, 79639, Grenzach-Wyhlen, Deutschland

    S. M. Manth (Medizinischer Direktor) (Medizinischer Direktor)

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Holdener, E.E., Massimini, G., Lippman, S., Bollag, W., Man, A. (1994). Das Zervixkarzinom. Gegenwärtiger Stand und neue Aspekte der systemischen Therapie. In: Bastert, G., Wallwiener, D., Manth, S.M. (eds) Immuntherapie in der gynäkologischen Onkologie. AGO Arbeitsgemeinschaft für Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78845-1_7

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