Prostate cancer is an important public health problem with over a quarter of a million new cases diagnosed worldwide in 1985 (Parkin et al. 1993). The incidence of the disease is increasing rapidly in most regions of the world (Boyle 1994; Alexander and Boyle, this volume) although the mortality rate has remained constant in generations of men born since the early years of this century (Boyle et al. 1994). The evidence that prostate cancer risk has important environmental determinants is compelling. Briefly, different populations around the world experience different levels of prostate cancer, and these levels change with time usually in an orderly and predictable manner: international variation in incidence is around two orders of magnitude (Boyle et al. 1994). However, when migration takes place, groups of migrants tend to acquire the prostate cancer pattern of their new home (Haenszel 1961). Furthermore, groups within a community whose life-style habits differentiate them from other members of the same community generally have notably different prostate cancer rates, for example, Seventh Day Adventists and Mormons (Zaridze and Boyle 1987).
KeywordsPlacebo Obesity Migration Rubber Testosterone
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