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Cytotoxic Glial Swelling by Arachidonic Acid

  • F. Staub
  • A. Winkler
  • J. Peters
  • O. Kempski
  • A. Baethmann
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 22)

Abstract

Arachidonic acid (AA, 20:4) is a major constituent of membrane phospholipids in brain tissue. Normally, the free fatty acid is present only in a small amount, but it accumulates under adverse conditions, such as ischemia or brain injury [1,9]. The release of free fatty acid involves activation of phospholipases and breakdown of membrane phospholipids. AA in particular is considered to mediate pathological processes. The polyunsaturated compound is a precursor of prostaglandins, leukotrienes, and oxygen-derived free radicals [11]. In cerebral ischemia concentrations of free AA of up to 0.5 mM/kg have been found in brain tissue [9].

Keywords

Free Fatty Acid Arachidonic Acid Stearic Acid Cytotoxic Brain Edema Modify Minimal Essential Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • F. Staub
    • 1
  • A. Winkler
    • 1
  • J. Peters
    • 1
  • O. Kempski
    • 2
  • A. Baethmann
    • 1
  1. 1.Institut für Chirurgische Forschung, Klinikum GroßhadernLudwig-Maximillians-UniversitätMünchenGermany
  2. 2.Institut für Neurochirurgische PathophysiologieJohannes-Gutenberg-UniversitätMainzGermany

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