Cytotoxic Glial Swelling by Arachidonic Acid
Arachidonic acid (AA, 20:4) is a major constituent of membrane phospholipids in brain tissue. Normally, the free fatty acid is present only in a small amount, but it accumulates under adverse conditions, such as ischemia or brain injury [1,9]. The release of free fatty acid involves activation of phospholipases and breakdown of membrane phospholipids. AA in particular is considered to mediate pathological processes. The polyunsaturated compound is a precursor of prostaglandins, leukotrienes, and oxygen-derived free radicals . In cerebral ischemia concentrations of free AA of up to 0.5 mM/kg have been found in brain tissue .
KeywordsPermeability Peroxide Ischemia EDTA Superoxide
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