Magnetic Resonance Imaging-Guided Interstitial Laser Therapy in Brain Tumors
Laser-induced interstitial thermotherapy (LITT) is a minimally invasive technique of local brain tumor destruction. The concept of interstitial hyperthermia was first evaluated in experimental studies by Bown in 1983 . For a safe clinical application it is mandatory to define the extent of thermally mediated laser-induced damage to the tissue. Jolesz and coworkers studied the sensitivity of magnetic resonance imaging (MRI) to visualize laser-induced tissue changes . MRI proved to be well suited for monitoring LITT due to its high soft-tissue contrast and its sensitivity for temperature changes. In this paper we report our experiences with MRI-guided LITT in eight patients with intracranial tumors.
KeywordsHydrocortisone Reso Astrocytoma Paration Aphasia
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- 3.Bettag M, Schober R, Sabel M, Ulrich F, Schwarzmaier HJ, Hessel S (1992) Laser-induzierte interstitielle Thermotherapie — experimentelle Untersuchungen am Rattenhirn. Lasermedizin 8:58–62Google Scholar
- 4.Bettag M, Ulrich F, Fürst G, Langen UJ, Roosen N, Kiwit JCW, Hessel S, Mödder U, Bock WJ (1991) Gadolinium-DPTA-enhanced MRI and positron emission tomography of stereotactic laser-induced interstitial thermal therapy of cerebral gliomas. Neuroradiology 33:37–39Google Scholar
- 5.Bettag M, Ulrich F, Schober R, Bock WJ (1991) Stereotactic laser therapy in cerebral gliomas. Acta Neurochir (Wien) 52:81–83Google Scholar
- 8.LeBihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505Google Scholar
- 9.LeBihan D, Delannoy J, Levin RL (1989) Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia. Radiology 171:853–857Google Scholar