Magnetic Resonance Imaging-Guided Interstitial Laser Therapy in Brain Tumors
Laser-induced interstitial thermotherapy (LITT) is a minimally invasive technique of local brain tumor destruction. The concept of interstitial hyperthermia was first evaluated in experimental studies by Bown in 1983 . For a safe clinical application it is mandatory to define the extent of thermally mediated laser-induced damage to the tissue. Jolesz and coworkers studied the sensitivity of magnetic resonance imaging (MRI) to visualize laser-induced tissue changes . MRI proved to be well suited for monitoring LITT due to its high soft-tissue contrast and its sensitivity for temperature changes. In this paper we report our experiences with MRI-guided LITT in eight patients with intracranial tumors.
KeywordsLaser Fiber Laser Therapy Perifocal Edema Interstitial Thermotherapy Zonal Architecture
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