Cerebral Gangliogliomas: A Study of 51 Cases

  • R. Kristof
  • J. Zentner
  • B. Ostertun
  • H. Wolf
  • M. Campos
  • J. Schramm
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 22)


Gangliogliomas are rather infrequent lesions of the central nervous system that account for 0.4%–1.3% of all brain tumors, with a higher incidence in infancy [13, 18]. The term ganglioglioma was originally proposed by Ewing in 1926 (cited in [16]). Due to their low frequency, most reports on these tumors are casuistic, and except for the study by Henry et al. [11], only a few minor series have been published [3, 5, 12, 18]. During the past 5 years we have operated on 51 patients with gangliogliomas and report on our findings here.


Magnetic Resonance Imaging Feature Focal Neurological Deficit Cranial Nerve Deficit Hypodense Lesion Complete Tumor Removal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Albright L, Byrd RP (1980) Ganglioglioma of the entire spinal cord. Childs Brain 6:274–280PubMedGoogle Scholar
  2. 2.
    Bevilacqua G, Sarnelli R (1979) Ganglioglioma of the spinal cord. A case with long survival. Acta Neuropathol (Berl) 48:239–242CrossRefGoogle Scholar
  3. 3.
    Castillo M, Davis PC, Takei Y, Hoffmann JC (1990) Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. AJR 154:607–612PubMedGoogle Scholar
  4. 4.
    Cheung YK, Fung CF, Chan FU, Leong LLY (1991) MRI features of spinal ganglioglioma. Clin Imag 15:109–112CrossRefGoogle Scholar
  5. 5.
    Courville CB (1930) Ganglioglioma: tumors of the central nervous system; review of the literature and report of two cases. Arch Neurol Psychiatr 24:439–492Google Scholar
  6. 6.
    Dorne HL, O’Gorman AM, Melanson D (1986) Computed tomography of intracranial gangliogliomas. AJNR 7:281–285PubMedGoogle Scholar
  7. 7.
    Doyle JB, Kernohan JW (1931) Ganglioneuroma of the third ventricle with diabetes insipidus and hypopituitarism. J Nerv Ment Dis 73:55–61CrossRefGoogle Scholar
  8. 8.
    Garcia CA, McGarry PA, Collada (1984) Ganglioglioma of the brain stem. Case report. J Neurosurg 60:431–434PubMedCrossRefGoogle Scholar
  9. 9.
    Gritzman MCD, Snyckers FD, Proctor NSF (1983) Ganglioglioma of the optic nerve. A case report. S Afr Med J 63:863–865PubMedGoogle Scholar
  10. 10.
    Haddad SF, Moore SA, Menezes AH, Van Gilder JC (1992) Ganglioglioma: 13-years of experience. Neurosurgery 31:171–178PubMedCrossRefGoogle Scholar
  11. 11.
    Henry JM, Heffner RR, Earle KM (1978) Gangliogliomas of the CNS: a clinicopathological study of 50 cases. J Neuropathol Exp Neurol 37:626 (abstract)Google Scholar
  12. 12.
    Johannsson JH, Rekate HL, Roessmann U (1981) Gangliogliomas: pathological and clinical correlation. J Neurosurg 54:58–63PubMedCrossRefGoogle Scholar
  13. 13.
    Kalyan-Ramon UP, Olivero WC (1987) Ganglioglioma: a correlative clinicopathological and radiological study of ten surgically treated cases with follow-up. Neurosurgery 20:428–433CrossRefGoogle Scholar
  14. 14.
    Katz MC, Kier EL, Schechter MM (1972) The radiology of gangliogliomas and glioneuromas of the central nervous system. Neuroradiology 4:69–73PubMedCrossRefGoogle Scholar
  15. 15.
    Packen RJ, Sutton LN, Rosenstock JG et al. (1984) Pineal region tumors of childhood. Pediatrics 74:97–102Google Scholar
  16. 16.
    Perkins OC (1926) Ganglioglioma. Arch Pathol Lab Med 2:11Google Scholar
  17. 17.
    Russel DS, Rubinstein LJ (1977) Pathology of the tumors of the nervous system, 4th edn. William and Wilkins, Baltimore, pp 261–262Google Scholar
  18. 18.
    Silver JM, Rawlings CE, Rossitch E, Zeidman SM, Friedman AH (1991) Ganglioglioma: a clinical study with long-term follow-up. Surg Neurol 35:261–266PubMedCrossRefGoogle Scholar
  19. 19.
    Sutton LN, Packer RJ, Rorke LB, Bruce DA, Shut L (1983) Cerebral gangliogliomas during childhood. Neurosurgery 13:124–128PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. Kristof
    • 1
  • J. Zentner
    • 1
  • B. Ostertun
    • 2
  • H. Wolf
    • 3
  • M. Campos
    • 1
  • J. Schramm
    • 1
  1. 1.Department of NeurosurgeryUniversity of BonnBonnGermany
  2. 2.Department of NeuroradiologyUniversity of BonnBonnGermany
  3. 3.Institute of NeuropathologyUniversity of BonnBonnGermany

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