Immunization of Thalassaemic Patients Against the Ag System

  • C. Politis
  • E. Butler
  • R. Butler
  • H. Vrettou
  • C. Richardson
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 5)

Abstract

Patients with homozygous b-thalassaemia may develop a variety of allo-antibodies against blood cell antigens and serum protein antigens as a result of multiple transfusions. Previous studies in our thalassaemia unit and elsewhere have shown that the incidence of red cells alloantibodies is lower than expected, whereas the frequency of allo-antibodies against low density lipoproteins in high (1–3).

Keywords

Allo Thalassemia Sera Washing 

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Selected Bibliography

  1. 1.
    Lostumbo MM, Holland PV, Schmidt PJ. Isoimmunization after multiple transfusion. N Engl J Med 1966; 275: 141.PubMedCrossRefGoogle Scholar
  2. 2.
    Economidou J, Politis C, Kattamis C. Problems related to transfusion therapy of patients with thalassaemia in Greece. In: Therapy of Thalassemia. The Modeterranean Experience, (Eds) G. Sirchia, A. Zanella, Milano 1985.Google Scholar
  3. 3.
    Butler R, Gerber H, Economidou J, Avgoustaki 0, Karamerou A, Politis C. Immunization of thalassaemic patients against red cell, leukocyte and thrombocyte antigens and against IgA and low density lipoprotein. 19th Congress Inter. Soc. Haematol. Budapest 1982.Google Scholar
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    Breguet G, Butler R, Butler-Brunner E, Sanchez-Mazas A. A worldwide population study of the Ag-System haplotypes, a genetic polymorphism of human low-density lipoprotein. Am J Hum Gent 1990; 46: 502–517.Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. Politis
    • 1
  • E. Butler
    • 2
  • R. Butler
    • 2
  • H. Vrettou
    • 1
  • C. Richardson
    • 1
  1. 1.Hellenic Red Cross Blood Transfusion CentreAthensGreece
  2. 2.Central LaboratorySwiss Red Cross Blood Transfusion ServiceSwitzerland

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