Two Cases of Duplication of the 1F and 1A2 Genes in the Vitamin D-Binding Protein (GC) System

  • Goichi Ishimoto
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 5)


GC polymorphism in Japan is a bit unique in distribution of the phenotypes, because a variant allele(1A2) also retains in a polymorphic frequency (around 0.02) in addition to the three common alleles(GC 1F,1S & 2). Recently Yasuda et al. (1989)1) found a new GC variant, GC 2-1F1A2, which is charac­terized by having double double-banded components with a common GC 2 band by PAGIF, and presumed it had arisen from duplication of the GC 1F and 1A2 genes. Later the same variant type was observed by others 2) – 4) in Japanese populations, and it is estimated such duplication is occurring with a frequency of 0.001 2). However, the variant has sofar been identified only in the samples with GC 2.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Yasuda T, Ikehara Y, Takagi S, Mizuta K and Kishi K(1989) Hum Genet 82: 89–91CrossRefGoogle Scholar
  2. 2).
    Sawazaki K, Yamada T, Yasuda T, Mizuta K and Kishi K (1990) Hum Hered 40: 187–189PubMedCrossRefGoogle Scholar
  3. 3).
    Kishida T, Fukuda M and Tamaki Y(1991) Jpn J Legal Med 45:411–415Google Scholar
  4. 4).
    Kubo S, Kitamura O, Tsuda R, Hirose W, Matsumoto H and Nakasono I(1993) Hum Genet 91: 71–72PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Goichi Ishimoto
    • 1
  1. 1.Department of Legal MedicineMie University School of MedicineTsuJapan

Personalised recommendations