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Two Cases of Duplication of the 1F and 1A2 Genes in the Vitamin D-Binding Protein (GC) System

  • Goichi Ishimoto
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 5)

Abstract

GC polymorphism in Japan is a bit unique in distribution of the phenotypes, because a variant allele(1A2) also retains in a polymorphic frequency (around 0.02) in addition to the three common alleles(GC 1F,1S & 2). Recently Yasuda et al. (1989)1) found a new GC variant, GC 2-1F1A2, which is charac­terized by having double double-banded components with a common GC 2 band by PAGIF, and presumed it had arisen from duplication of the GC 1F and 1A2 genes. Later the same variant type was observed by others 2) – 4) in Japanese populations, and it is estimated such duplication is occurring with a frequency of 0.001 2). However, the variant has sofar been identified only in the samples with GC 2.

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Reference

  1. 1).
    Yasuda T, Ikehara Y, Takagi S, Mizuta K and Kishi K(1989) Hum Genet 82: 89–91CrossRefGoogle Scholar
  2. 2).
    Sawazaki K, Yamada T, Yasuda T, Mizuta K and Kishi K (1990) Hum Hered 40: 187–189PubMedCrossRefGoogle Scholar
  3. 3).
    Kishida T, Fukuda M and Tamaki Y(1991) Jpn J Legal Med 45:411–415Google Scholar
  4. 4).
    Kubo S, Kitamura O, Tsuda R, Hirose W, Matsumoto H and Nakasono I(1993) Hum Genet 91: 71–72PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Goichi Ishimoto
    • 1
  1. 1.Department of Legal MedicineMie University School of MedicineTsuJapan

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