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APOB 3′ VNTR Polymorphism in Southern African Populations

  • A. B. Lane
  • I. Marques
  • T. Jenkins
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 5)

Abstract

Inter-ethnic differences in allele frequency distributions of VNTR containing loci exist and should be taken into account when using such systems for forensic purposes. The aim of the present study has been to determine whether significant differences in apoB 3′ VNTR allele frequency distribution are detectable between southern African Negroids and Caucasoids and between subdivisions of these groups.

Keywords

Allele Frequency Distribution Hellinger Distance Forensic Purpose South African Institute VNTR Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Boerwinkle E, Xiong W, Fourest E and Chan L (1989) Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: Application to the apolipoprotein B 3’ hypervariable region. Proc. Natl. Acad. Sci. USA 86: 212–216Google Scholar
  2. Devlin B and Risch N (1992a) Ethnic differentiation at VNTR loci, with special reference to forensic applications. Am. J. Hum Genet. 51: 534–548PubMedGoogle Scholar
  3. Devlin B and Risch N (1992b) A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation’s fixed-bin method. Am. J. Hum. Genet. 51: 549–553PubMedGoogle Scholar
  4. Jenkins T, Zoutendyk A, Steinberg A G (1970) Gammaglobulin groups (Gm and Inv) of various southern African populations. Am. J. Phys. Anthrop. 32: 197–218Google Scholar
  5. Marques I (1992) Variable number of tandem repeat polymorphisms of man in southern Africa. Ph.D thesis, University of the Witwatersrand, Johannesburg.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. B. Lane
    • 1
  • I. Marques
    • 1
  • T. Jenkins
    • 1
  1. 1.MRC Human Ecogenetics Research Unit, Department of Human Genetics, School of PathologySouth African Institute for Medical Research and University of the WitwatersrandJohannesburgSouth Africa

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