Analysis by PCR/Oligonucleotide Typing of HLA Class II Alleles in a Variety of Human Populations
The analysis of allele frequency distributions in various human populations can provide valuable anthropologic genetics information as well as useful data for forensics inferences about identity. One of the more controversial issues in the area of forensic inference, has been the question of population substructure and how this might effect the calculations of statistical weight (i.e., likelihood of a “random match”) associated with an inclusionary result. The issue of substructure within the so-called census populations and the possibility that different subpopulations can have significantly different allele frequencies can be addressed most directly by determining the allele frequencies in many different population groups.
KeywordsHuman Leukocyte Antigen Human Leukocyte Antigen Class Allele Frequency Distribution Population Substructure DRB1 Allele
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