Abstract
PCR-based DNA typing has become a valid alternative for the time-consuming and laborious typing of VNTR loci by Southern blot analysis. It has not only increased the sensitivity of DNA typing to levels of a few nanogram of DNA but it allows also to have a higher resolution for small size differences. Genotyping becomes possible which is in contrast to conventional Southern blot methods where the low resolution for small size differences, sometimes, lead to ‘pseudo-homozygosity’ (1).
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References
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© 1994 Springer-Verlag Berlin Heidelberg
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Decorte, R., Marynen, P., Cassiman, JJ. (1994). High Resolution Analysis by PCR on an Automated DNA Sequencer of Internal Variation at a Pseudoautosomal VNTR (DXYS17). In: Bär, W., Fiori, A., Rossi, U. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78782-9_115
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DOI: https://doi.org/10.1007/978-3-642-78782-9_115
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