Identification of Human Remains Using Mitochondrial DNA Sequencing: Potential Mother-Child Mutational Events

  • M. M. Holland
  • R. K. Roby
  • D. L. Fisher
  • J. Ruderman
  • D. A. Lee
  • C. K. Bryson
  • T. Kupferschmid
  • R. S. Lofts
  • A. J. Eisenberg
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 5)


Determining the primary sequence of DNA is the ultimate form of DNA testing for discriminating between individuals. Various DNA sequencing methodologies are currently available, although the dideoxynucleotide “terminator” chemistry of Sanger is the most widely used in laboratories today (1,2). The development of fluorescence and infrared-based detection methods, coupled with automated DNA sequencing instruments, has greatly improved throughput and efficiency (3–7). Therefore, sequencing technology is readily available to most laboratories, and automation has made the process more cost effective.


Hypervariable Region Sterile Deionized Water Human Remains Purine Nucleotide Pyrimidine Nucleotide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • M. M. Holland
    • 1
  • R. K. Roby
    • 1
  • D. L. Fisher
    • 1
  • J. Ruderman
    • 1
  • D. A. Lee
    • 1
  • C. K. Bryson
    • 1
  • T. Kupferschmid
    • 1
  • R. S. Lofts
    • 1
  • A. J. Eisenberg
    • 2
  1. 1.The Armed Forces DNA Identification LaboratoryThe Armed Forces Institute of PathologyUSA
  2. 2.Department of PathologyUniversity of North Texas Health Science CenterFt. WorthUSA

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