Abstract
Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder (Shoenfeld and Isenberg 1989). Its diagnosis relies on a set of criteria established by the American College of Rheumatology (Tan et al 1982). There is compelling evidence that the genetic background plays an important role, not only in the susceptibility to the disease, but also in its clinical and serological expression (Arnett and Reveille 1992). The first association of SLE with a genetic trait was reported in 1971 with the HLA class I allele B8 (Grumet et al 1971). Subsequently a large number of family and population studies have confirmed this finding. However it is also known that environmental factors play an important role.
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© 1994 Springer-Verlag Berlin Heidelberg
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Youinou, P. et al. (1994). Genetic and environmental factors in Systemic lupus erythematosus. In: Zouali, M. (eds) Autoimmunity: Experimental Aspects. NATO ASI Series, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78779-9_18
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DOI: https://doi.org/10.1007/978-3-642-78779-9_18
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