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The Expression of Heat Shock Proteins in Systemic Lupus Erythematosus

  • Veena B. Dhillon
  • David S. Latchman
  • David A. Isenberg
Part of the NATO ASI Series book series (volume 80)

Abstract

The heat shock response (HSR) was discovered in Drosophila buksii over 30 years ago [Ritossa 1962], and subsequently characterized by Tissières et al [1974] who showed that it consisted of the rapid synthesis of a small number of new proteins - the heat shock proteins (hsps) - against a background of repressed general protein synthesis, upon exposure of organisms to a variety of insults. These include hypoxia, glucose deprivation or supplementation, amino acid analogues, oxygen free radicals, cytokines, heavy metals, calcium ionophores, ethanol and many infectious pathogens [Linquist 1986]. The common denominator appears to be the accumulation of unfolded or malfolded proteins in the cell [Gething and Sambrook 1992]. The HSR has been observed in all cell systems, tissues and organisms studied. There is a high degree of homology of hsps phylogenetically. They thus appear to have an important role to play in cell survival. This is borne out by the fact that both the protein-coding and the regulatory sequences of some heat shock genes have been very highly conserved throughout evolution. However, while the HSR is ubiquitous, it is also finely tuned and versatile.

Keywords

Systemic Lupus Erythematosus Ankylose Spondylitis Heat Shock Protein Systemic Lupus Erythematosus Patient Heat Shock Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Veena B. Dhillon
    • 1
    • 2
  • David S. Latchman
    • 1
  • David A. Isenberg
    • 2
  1. 1.Division of Molecular PathologyUniversity College and Middlesex School of MedicineLondonUK
  2. 2.Department of Rheumatology ResearchUniversity College and Middlesex School of MedicineLondonUK

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