Zusammenfassung
Die Myokardischämie wird traditionell als ein Mißverhältnis zwischen dem Energieangebot durch die Koronardurchblutung und dem Energiebedarf im wesentlichen für die Myokardkontraktion verstanden. Die Befunde, die diese Vorstellung stützen, haben jedoch dem grundsätzlich regionalen Charakter der Myokardischämie nicht Rechnung getragen. Einerseits wurde in vielen Fällen nicht die regionale myokardiale Durchblutung gemessen, andererseits wurde der regionale Energiebedarf der ischämischen Region aus dem Bedarf des gesamten Herzens oder dem Bedarf nichtischämischer Areale geschätzt. Die Koronargefäße werden in der klassischen Vorstellung der Myokardischämie als maximal weitgestellt angesehen, und Veränderungen der Myokarddurchblutung werden deshalb der extravaskulären Kompression zugeschrieben.
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Literatur
Heusch G (1989) Koronare Vasomotion bei Myokardischämie. Z Kardiol 78: 485–499
Hoffman JIE (1987) Transmural myocardial perfusion. Prog Cardiovasc Dis 29: 429–464
McHale PA, Dube GP, Greenfield JC Jr (1987) Evidence for myogenic vasomotor activity in the coronary circulation. Prog Cardiovasc Dis 30: 139–146
Jones CJH, Kuo L, Davis MJ, Chilian WM (1993) Myogenic and flow-dependent control mechanisms in the coronary microcirculation. Basic Res Cardiol 88: 2–10
Olsson RA, Bünger R (1987) Metabolic control of coronary blood flow. Prog Cardiovasc Dis 29: 369–387
Bassenge E, Busse R (1988) Endothelial modulation of coronary tone. Prog Cardiovasc Dis 30: 349–380
Young MA, Knight DR, Vatner SF (1987) Autonomic control of large coronary arteries and resistance vessels. Prog Cardiovasc Dis 30: 211–234
Heusch G, Guth BD (1989) Neurogenic regulation of coronary vasomotor tone. Eur Heart J 10 (Suppl F): 6–14
Heusch G (1990) a-adrenergic mechanisms in myocardial ischemia. Circulation 81:1–13
Bassenge E, Heusch G (1990) Endothelial and neuro-humoral control of coronary blood flow in health and disease. Rev Physiol Biochem Pharmacol 116: 77–165
Mates RE, Gupta RL, Bell AC, Klocke FJ (1978) Fluid dynamics of coronary artery stenosis. Circ Res 42: 152–162
Gould KL (1980) Dynamic coronary stenosis. Am J Cardiol 45: 286–292
Schwartz JS, Carlyle PF, Cohn JN (1979) Effect of dilation of the distal coronary bed on flow and resistance in severely stenotic coronary arteries in the dog. Am J Cardiol 43: 219–224
Heusch G, Yoshimoto N, Müller-Ruchholtz ER (1982) Effects of heart rate on hemodynamic severity of coronary artery stenosis in the dog. Basic Res Cardiol 77: 562–573
Schwartz JS, Tockman B, Cohn JN, Bache RJ (1982) Exercise-induced decrease in flow through stenotic coronary arteries in the dog. Am J Cardiol 50: 1409–1413
Schwartz JS, Carlyle PF, Cohn JN (1980) Effect of coronary arterial pressure on coronary stenosis resistance. Circulation 61: 70–76
Freudenberg H, Lichtlen PR (1981) Das normale Wandsegment bei Koronarstenosen–eine postmortale Studie. Z Kardiol 70: 863–869
Rafflenbeul W, Lichtlen PR (1982) Zum Konzept der „dynamischen“ Koronarstenose. Z Kardiol 71: 439–444
Santamore WP, Yelton BW Jr, Ogilby JD (1991) Dynamics of coronary occlusion in the pathogenesis of myocardial infarction. J Am Coll Cardiol 18: 1397–1405
Brown BG, Lee AB, Bolson EL, Dodge HT (1984) Reflex constriction of significant coronary stenosis as a mechanism contributing to ischemic left ventricular dysfunction during isometric exercise. Circulation 70: 18–24
Hossack KF, Brown BG, Stewart DK, Dodge HT (1984) Diltiazem-induced blockade of sympathetically mediated constriction of normal and diseased coronary arteries: lack of epicardial coronary dilatory effect in humans. Circulation 70: 465–471
Gage JE, Hess OM, Murakami T, Ritter M, Grimm J, Krayenbuehl HP (1986) Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin. Circulation 73: 865–876
MacAlpin RN (1980) Relation of coronary artery spasm to sites of organic stenosis. Am J Cardiol 46: 143–153
MacAlpin RN (1980) Contribution of dynamic vascular wall thickening to luminal narrowing during coronary arterial constriction. Circulation 60: 296–301
Serruys PW, Lablanche JM, Reiber JHC, Bertrand ME, Hugenholtz PG (1983) Contribution of dynamic vascular wall thickening to luminal narrowing during coronary arterial vasomotion. Z Kardiol 72 (Suppl 3): 116–123
Heusch G, Deussen A, Schipke J, Thämer V (1984) al-and a2-adrenoceptor-mediated vasoconstriction of large and small canine coronary arteries in vivo. J Cardiovasc Pharmacol 6: 961–968
Schroeder JS, Bolen JL, Quint RA, Clark DA, Hayden WG, Higgins CB, Wexler L (1977) Provocation of coronary spasm with ergonovine maleate: new test with results in 57 patients undergoing coronary arteriography. Am J Cardiol 40: 487–491
Heupler FA Jr, Proudfit WL, Razavi M, Shirey EK, Greenstreet R, Sheldon WC (1978) Ergonovine maleate provocative test for coronary arterial spasm. Am J Cardiol 41: 631–640
Holtz J, Held W, Sommer O, Kühne G, Bassenge E (1982) Ergonovine-induced constrictions of epicardial coronary arteries in conscious dogs: a-adrenoceptors are not involved. Basic Res Cardiol 77: 278–291
Henry PD, Yokoyama M (1980) Supersensitivity of atherosclerotic rabbit aorta to ergonovine. J Clin Invest 66: 306–313
Heistad DD, Armstrong ML, Marcus ML, Piegors DJ, Mark AL (1984) Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ Res 54: 711–718
Ginsburg R, Bristow MR, Kantrowitz N, Bairn S, Harrison DC (1981) Histamine provocation of clinical coronary artery spasm: implications concerning pathogenesis of variant angina pectoris. Am Heart J 102: 819–822
Zeiher AM, Drexler H, Wollschlaeger H, Saurbier B, Just H (1989) Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol 14: 1181–1190
Vita JA, Treasure CB, Yeung AC, Vekshtein VI, Fantasia GM, Fish RD, Ganz P, Selwyn AP (1992) Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increased in sensitivity to constrictor effects of catecholamines. Circulation 85: 1390–1397
Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (London) 288: 373–376
Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Cire Res 53: 557–573
Young MA, Vatner SF (1986) Enhanced adrenergic constriction of iliac artery with removal of endothelium in conscious dogs. Am J Physiol 250: H892 - H897
Schipke J, Heusch G, Deussen A, Thaemer V (1985) Acetylcholine induces constriction of epicardial coronary arteries in anesthetized dogs after removal of endothelium. Drug Res 35: 926–929
Lamping KG, Marcus ML, Dole WP (1985) Removal of the endothelium potentiates canine large coronary artery constrictor responses to 5-hydroxytryptamine in vivo. Cire Res 57: 4654
Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P (1986) Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 315: 1046–1051
Fish RD, Nabel EG, Selwyn AP, Ludmer PL, Mudge GH, Kirshenbaum JM, Schoen FJ, Alexander RW, Ganz P (1988) Responses of coronary arteries of cardiac transplant patients to acetylcholine. J Clin Invest 81: 21–31
Treasure CB, Manoukian SV, Klein JL, Vita JA, Nabel EG, Renwick GH, Selwyn AP, Alexander RW, Ganz P (1992) Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients. Circ Res 71: 776–781
Holtz J, Giesler M, Bassenge E (1983) Two dilatory mechanisms of anti-anginal drugs on epicardial coronary arteries in vivo: indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation. Z Kardiaol 72 (Suppl 3): 98–106
Holtz J, Förstermann U, Pohl U, Giesler M, Bassenge E (1984) Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition. J Cardiovasc Pharmacol 6: 1161–1169
Hintze TH, Vatner SF (1984) Reactive dilation of large coronary arteries in conscious dogs. Circ Res 54: 50–57
Tanner FC, Noll G, Boulanger CM, Lüscher TF (1991) Oxidized low density lipoproteins inhibit relaxation of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. Circulation 83: 2012–2020
Moncada S, Palmer RMJ, Higgs EA (1989) Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol 38: 1709–1715
Harrison DG, Marcus ML, Dellsperger KC, Lamping KG, Tomanek RJ (1991) Pathophysiology of myocardial perfusion in hypertension. Circulation 83 (Suppl III): III-14-III-18
Brush JE Jr, Faxon DP, Salmon S, Jacobs AK, Ryan TJ (1992) Abnormal endothelium-dependent coronary vasomotion in hypertensive patients. J Am Coll Cardiol 19: 809–815
Fam WM, McGregor M (1968) Effect of nitroglycerin and dipyridamole on regional coronary resistance. Circ Res 22: 649–659
Kelley KO, Feigl EO (1978) Segmental alpha-receptor-mediated vasoconstriction in the canine coronary circulation. Circ Res 43: 908–917
Chierchia S, Davies G, Berkenboom G, Crea F, Crean P, Maseri A (1984) a-adrenergic receptors and coronary spasm: an elusive link. Circulation 69: 8–14
Winniford MD, Filipchuk N, Hillis LD (1983) Alpha-adrenergic blockade for variant angina: a long-term, double-blind, randomized trial. Circulation 67: 1185–1188
DeCaterina R, Carpeggiani C, L’Abbate A (1984) A double-blind, placebo-controlled study of ketanserin in patients with Prinzmetal’s angina: evidence against a role of serotonin in the genesis of coronary vasospasm. Circulation 69: 889–894
Pitarys II CJ, Virmani R, Vildibill HD Jr, Jackson EK, Forman MB (1991) Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period. Circulation 83: 237–247
Clarke JG, Kerwin R, Larkin S, Lee Y, Yacoub M, Davies GJ, Hackett D, Dawbarn D, Bloom SR, Maseri A (1987) Coronary artery infusion of neuropeptide Y in patients with angina pectoris. Lancet 1, 2: 1057–1059
Mosher P, Ross J Jr, McFate PA, Shaw RF (1964) Control of coronary blood flow by an autoregulatory mechanism. Circ Res 14: 250–259
Marcus ML, Wright C, Doty D, Eastham C, Laughlin D, Krumm P, Fastenow C, Brody M (1981) Measurements of coronary velocity and reactive hyperemia in the coronary circulation of humans. Circ Res 49: 877–891
Klocke FJ (1987) Measurements of coronary flow reserve: defining pathophysiology versus making decisions about patient care. Circulation 76: 1183–1189
Gould KL, Lipscomb K, Calvert C (1975) Compensatory changes of the distal coronary vascular bed during progressive coronary constriction. Circulation 51: 1085–1094
Guyton RA, McClenathan JH, Newman GE, Michaelis LL (1977) Significance of subendocardial S-T segment elevation caused by coronary stenosis in the dog. Epicardial S-T segment depression, local ischemia and subsequent necrosis. Am J Cardiol 40: 373–380
Rouleau J, Boerboom LE, Surjadhana A, Hoffman JIE (1979) The role of autoregulation and tissue diastolic pressures in the transmural distribution of left ventricular blood flow in anesthetized dogs. Cire Res 45: 804–815
Gallagher KP, Folts JD, Shebuski RJ, Rankin JHG, Rowe GG (1980) Subepicardial vasodilator reserve in the presence of critical coronary stenosis in dogs. Am J Cardiol 46: 6773
Gorman MW, Sparks HV Jr (1982) Progressive coronary vasoconstriction during relative ischemia in canine myocardium. Circ Res 51: 411–420
Aversano T, Becker LC (1985) Persistence of coronary vasodilator reserve despite functionally significant flow reduction. Am J Physiol 248: H403 - H411
Canty JM, Klocke FJ (1985) Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve. Circulation 71: 370–377
Pantely GA, Bristow JD, Swenson LJ, Ladley HD, Johnson WB, Anselone CG (1985) Incomplete coronary vasodilation during myocardial ischemia in swine. Am J Physiol 249: H638 - H647
Grattan MT, Hanley FL, Stevens MB, Hoffman JIE (1986) Transmural coronary flow reserve patterns in dogs. Am J Physiol 250: H276 - H283
Heusch G, Guth BD, Seitelberger R, Ross J Jr (1987) Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine. Circulation 75: 482–490
Dole WP (1987) Autoregulation of the coronary circulation. Prog Cardiovasc Dis 29: 293–323
Dole WP, Nuno DW (1986) Myocardial oxygen tension determines the degree and pressure range of coronary autoregulation. Circ Res 59: 202–215
Gewirtz H, Brautigan DL, Olsson RA, Brown P, Most AS (1983) Role of adenosine in the maintenance of coronary vasodilation distal to a severe coronary artery stenosis. Observations in conscious domestic swine. Circ Res 53: 42–51
Bretschneider HJ (1967) Aktuelle Probleme der Koronardurchblutung and des Myokardstoffwechsels. Regensburger Jbl Ärztl Fortb 15: 1–27
Hoffman JIE (1978) Determinants and prediction of transmural myocardial perfusion. Circulation 58: 381–391
Coggins DL, Flynn AE, Austin RE Jr, Aldea GS, Muehrcke D, Goto M, Hoffman JIE (1990) Nonuniform loss of regional flow reserve during myocardial ischemia in dogs. Circ Res 67: 253–264
Canty JM (1992) Barbiturate-anesthesia does not affect coronary autoregulatory responses in closed-chest dogs. Faseb J 6: A1751 (Abstr)
Bristow JD, Arai AE, Anselone CG, Pantely GA (1991) Response to myocardial ischemia as a regulated process. Circulation 84: 2580–2587
Heusch G, Deussen A, Thämer V (1985) Cardiac sympathetic nerve activity and progressive vasoconstriction distal to coronary stenoses: feed-back aggravation of myocardial ischemia. J Auton Nery Syst 13: 311–326
Austin RE, Aldea GS, Coggins DL, Flynn AE, Hoffman JIE (1990) Profound spatial heterogeneity of coronary reserve. Discordance between patterns of resting and maximal myocardial blood flow. Circ Res 67: 319–331
Buffington CW, Feigl EO (1981) Adrenergic coronary vasoconstriction in the presence of coronary stenosis in the dog. Circ Res 48: 416–423
Johannsen UJ, Mark AL, Marcus ML (1982) Responsiveness to cardiac sympathetic nerve stimulation during maximal coronary dilation produced by adenosine. Circ Res 50: 510–517
Evers AS, Murphree S, Saffitz JE, Jakschik BA, Needleman P (1985) Effects of endogenously produced leukotrienes, thromboxane, and prostaglandins on coronary vascular resistance in rabbit myocardial infarction. J Clin Invest 75: 992–999
Nichols WW, Mehta JL, Thompson L, Donnelly WH (1988) Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function. Am J Physiol 255: H153 - H159
Ertl G (1987) Coronary vasoconstriction in experimental myocardial ischemia. J Cardiovasc Pharmacol 9 (Suppl 2): S 9-S 17
Pantely GA, Ladley HD, Anselone CG, Bristow JD (1985) Vasopressin-induced coronary constriction at low perfusion pressures. Cardiovasc Res 19: 433–441
Heusch G, Deussen A (1983) The effects of cardiac sympathetic nerve stimulation on the perfusion of stenotic coronary arteries in the dog. Circ Res 53: 8–15
Heusch G, Deussen A (1984) Nifedipine prevents sympathetic vasoconstriction distal to severe coronary stenoses. J Cardiovasc Pharmacol 6: 378–383
Heusch G (1985) Sympathische Herznerven and Myokardischämie. Thieme, Stuttgart New York
Tölle TR, Schipke JD, Schulz R, Thämer V, Haase J (1986) The nociceptive stimulation induced myocardial ischemia is prevented by fentanyl. Neurosci Lett Suppl 26: 522
Heusch G, Schipke J, Thämer V (1985) Clonidine prevents the sympathetic initiation and aggravation of poststenotic myocardial ischemia. J Cardiovasc Pharmacol 7: 1176–1182
Seitelberger R, Guth BD, Heusch G, Lee JD, Katayama K, Ross J Jr (1988) Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise. Circ Res 62: 436–442
Laxson DD, Dai X-Z, Homans DC, Bache RJ (1989) The role of ar and u2-adrenergic receptors in mediation of coronary vasoconstriction in hypoperfused ischemic myocardium during exercise. Circ Res 65: 1688–1697
Chilian WM (1991) Functional distribution of al-and a2-adrenergic receptors in the coronary microcirculation. Circulation 84: 2108–2122
Liang IYS, Jones CE (1985) Alpha 1-adrenergic blockade increases coronary blood flow during coronary hypoperfusion. Am J Physiol 249: H1070 - H1077
Guth BD, Miura T, Thaulow E, Heusch G, Ross J Jr (1993) Alpha 1-adrenergic blockade reduces exercise-induced regional myocardial ischemia in dogs. Basic Res Cardiol 88: 282–296
Nathan HJ, Feigl EO (1986) Adrenergic vasoconstriction lessens transmural steal during coronary hypoperfusion. Am J Physiol 250: H645 - H653
Miyamoto MI, Rockman HA, Guth BD, Heusch G, Ross J Jr (1991) Effect of a-adrenergic stimulation on regional contractile function and myocardial blood flow with and without ischemia. Circulation 84: 1715–1724
Constantine JW, Lebel W (1980) Complete blockade by phenoxybenzamine of alphas-but not alpha2-vascular receptors in dogs and the effect of propranolol. Naunyn Schmiedebergs Arch Pharmacol 314: 149–156
Chen D, Dai X-Z, Zimmerman BG, Bache RJ (1988) Postsynaptic a1- and a2-adrenergic mechanisms in coronary vasoconstriction. J Cardiovasc Pharmacol 11: 61–67
Heusch G, Yoshimoto N, Heegemann H, Thämer V (1983) Interaction of methoxamine with compensatory vasodilation distal to coronary stenoses. Drug Res 33: 1647–1650
Deussen A, Heusch G, Thämer V (1985) Alpha 2-adrenoceptor–mediated coronary vasoconstriction persists after exhaustion of coronary dilator reserve. Eur J Pharmacol 115: 147–153
Chilian WM, Ackell PH (1988) Transmural differences in sympathetic coronary constriction during exercise in the presence of coronary stenosis. Circ Res 62: 216–225
Chilian WM, Harrison DG, Haws CW, Snyder WD, Marcus ML (1986) Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels. Circ Res 58: 68–82
Mueller HS, Rao PS, Rao PB, Gory DJ, Mudd JG, Ayres SM (1982) Enhanced transcardiac 1-norepinephrine response during cold pressor test in obstructive coronary artery disease. Am J Cardiol 50: 1223–1228
Mudge GH, Grossman W, Mills RM Jr, Lesch M, Braunwald E (1976) Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N Engl J Med 295: 1333–1337
Mudge GH, Goldberg S, Gunther S, Mann T, Grossman W (1979) Comparison of metabolic and vasoconstrictor stimuli on coronary vascular resistance in man. Circulation 59: 544–550
Malacoff RF, Mudge GH, Holman BL, Idoine J, Bifolck L, Cohn PF (1983) Effect of the cold pressor test on regional myocardial blood flow in patients with coronary artery disease. Am Heart J 106: 78–84
Indolfi C, Piscione F, Villari B, Russolillo E, Rendina V, Golino P, Condorelli M, Chiariello M (1992) Role of a2-adrenoceptors in normal and atherosclerotic human coronary circulation. Circulation 86: 1116–1124
Berkenboom GM, Abramowicz M, Vandermoten P, Degre SG (1986) Role of alphaadrenergic coronary tone in exercise-induced angina pectoris. Am J Cardiol 57: 195–198
Chierchia S, Pratt T, DeCoster P, Maseri A (1985) Alpha-adrenergic control of collateral flow: another determinant of coronary flow reserve. Circulation 72 (Suppl I II ): 190 (Abstr)
Motulsky HJ, Snavely MD, Hughes RJ, Insel PA (1983) Interaction of verapamil and other calcium channel blockers with at-and a2-adrenergic receptors. Circ Res 52: 226–231
Rowe GG (1970) Inequalities of myocardial perfusion in coronary artery disease („coronary steal“). Circulation 42: 193–194
Baumgart D, Ehring T, Krajcar M, Heusch G (1993) A proischemic effect of nisoldipine: Relation to a decrease in perfusion pressure and comparison to dipyridamole. Cardiovasc Res 27: 1254–1259
Heusch G, Yoshimoto N (1983) Effects of heart rate and perfusion pressure on segmental coronary resistances and collateral perfusion. Pfluegers Arch 397: 284–289
Busch P, Deussen A, Heusch G (1988) Sympathetic effects on segmental coronary resistances and their role in coronary collateral perfusion. J Appl Cardiol 3: 145–160
Diemer HP, Wichmann J, Lochner W (1977) Coronary collateral flow: effect of drugs and perfusion pressure. Basic Res Cardiol 72: 332–343
Ertl G, Simm F, Wichmann J, Fuchs M, Lochner W (1979) The dependence of coronary collateral blood flow on regional vascular resitances. Naunyn Schmiedebergs Arch Pharmacol 308: 265–272
Maruoka Y, McKirnan MD, Engler RL, Longhurst JC (1987) Functional significance of alpha-adrenergic receptors in mature coronary collateral circulation of dogs. Am J Physiol 253: H582 - H590
Harrison DG, Chilian WM, Marcus ML (1986) Absence of functioning alpha-adrenergic receptors in mature canine coronary collaterals. Circ Res 59: 133–142
Gallagher KP, Osakada G, Matsuzaki M, Kemper WS, Ross J Jr (1982) Myocardial blood flow and function with critical coronary stenosis in exercising dogs. Am J Physiol 243: H698 - H707
Matsuzaki M, Patritti J, Tajimi T, Miller M, Kemper WS, Ross J Jr (1984) Effects of 13-blockade on regional myocardial flow and function during exercise. Am J Physiol 247: 1152 - H60
Matsuzaki M, Gallagher KP, Patritti J, Tajimi T, Kemper WS, White FC, Ross J Jr (1984) Effects of a calcium-entry blocker (diltiazem) on regional myocardial flow and function during exercise in conscious dogs. Circulation 69: 801–814
Matsuzaki M, Guth BD, Tajimi T, Kemper WS, Ross J Jr (1985) Effects of the combination of diltiazem and atenolol on exercis-induced regional myocardial ischemia in conscious dogs. Circulation 72: 233–243
Guth BD, Tajimi T, Seitelberger R, Lee JD, Matsuzaki M, Ross J Jr (1986) Experimental exercise-induced ischemia: Drug therapy can eliminate regional dysfunction and oxygen supply-demand imbalance. J Am Coll Cardiol 7: 1036–1046
Guth BD, Heusch G, Seitelberger R, Ross J Jr (1987) Mechanism of beneficial effect of betaadrenergic blockade on exercise-induced myocardial ischemia in conscious dogs. Circ Res 60: 738–746
Guth BD, Heusch G, Seitelberger R, Ross J Jr (1987) Elimination of exercise-induced regional myocardial dysfunction by a bradycardic agent in dogs with chronic coronary stenosis. Circulation 75: 661–669
Heusch G (1991) The relationship between regional blood flow and contractile function in normal, ischemic, and reperfused myocardium. Basic Res Cardiol 86: 197–218
Gallagher KP, Matsuzaki M, Osakada G, Kemper WS, Ross J Jr (1983) Effect of exercise on the relationship between myocardial blood flow and systolic wall thickening in dogs with acute coronary stenosis. Circ Res 52: 716–729
Indolfi C, Guth BD, Miura T, Miyazaki S, Schulz R, Ross J Jr (1989) Mechanisms of improved ischemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine. Circulation 80: 983–993
Reimer KA, Lowe JE, Rasmussen MM, Jennings RB (1977) The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 56: 786–794
Rahimtoola SH (1985) A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72 (Suppl V): V-123-V-135
Schipke JD (1991) Down-regulation and hibernating myocardium. Z Kardiol 80: 703–711
Heyndrickx GR, Millard RW, McRitchie RJ, Maroko PR, Vatner SF (1975) Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 56: 978–985
Braunwald E, Kloner RA (1982) The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation 66: 1146–1149
Bolli R (1990) Mechanism of myocardial „stunning“. Circulation 82: 723–738
Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124–1136
Jennings RB, Murry CE, Reimer KA (1991) Preconditioning myocardium with ischemia. Cardiovasc Drugs Ther 5: 933–938
Marban E (1991) Myocardial stunning and hibernation. The physiology behind the colloquialisms. Circulation 83: 681–688
Schaper W (1991) „Hibernating myocardium“. Zeit für einen Paradigmenwechsel? Z Kardiol 80:712–715
Tennant R, Wiggers CJ (1935) The effect of coronary occlusion on myocardial contraction. Am J Physiol 112: 351–361
Hearse DJ (1979) Oxygen deprivation and early myocardial contractile failure: a reassessment of the possible role of adenosine triphosphate. Am J Cardiol 44: 1115–1121
Guth BD, Martin JF, Heusch G, Ross J Jr (1987) Regional myocardial blood flow, function and metabolism using phosphorus-31 nuclear magnetic resonance spectroscopy during ischemia and reperfusion. J Am Coll Cardiol 10: 673–681
Arai AE, Pantely GA, Thoma WJ, Anselone CG, Bristow JD (1992) Energy metabolism and contractile function after 15 beats of moderate myocardial ischemia. Circ Res 70: 1137–1145
Katz AM (1973) Effects of ischemia on the contractile processes of heart muscle. Am J Cardiol 32: 456–460
Kübler W, Katz AM (1977) Mechanism of early „pump“ failure of the ischemic heart: possible role of adenosine triphosphate depletion and inorganic phosphate accumulation. Am J Cardiol 40: 467–471
Noma A (1983) ATP-regulated K channels in cardiac muscle. Nature (London) 305: 147–148
Gerlach E, Deuticke B, Dreisbach RH (1963) Der Nucleotid-Abbau im Herzmuskel bei Sauerstoffmangel and seine mögliche Bedeutung für die Coronardurchblutung. Naturwissenschaften 6: 228–229
Kirsch GE, Codina J, Birnbaumer L, Brown AM (1990) Coupling of ATP-sensitive K channels to Al receptors by G proteins in rat ventricular myocytes. Am J Physiol 259: H820 - H826
Nichols CG, Ripoll C, Lederer WJ (1991) ATP-sensitive potassium channel modulation of guinea pig ventricular action potential and contraction. Circ Res 68: 280–287
Reffelmann T,’ Kammermeier H (1992) Energetics and function of hypoxic isolated rat hearts as influenced by modulation of the K--ATP-channel-system. Pfluegers Arch 420 (Suppl 1): R105
Ingwa1l JS, Bittl JA (1987) Regulation of heart creatine kinase. Basic Res Cardiol 82 (Suppl 1): 93–101
Kammermeier H (1963) Verhalten von Adenin-Nukleotiden and Kreatininphosphat im Herzmuskel bei funktioneller Erholung nach länger dauernder Asphyxie. Verh Dtsch Ges Kreislaufforsch 30: 206–211
Camacho SA, Lanzer P, Toy BJ, Gober J, Velenza M, Botvinick EH, Weiner MW (1988) In vivo alterations of high-energy phosphates and intracellular pH during reversible ischemia in pigs: a 31p magnetic resonance spectroscopy study. Am Heart J 116: 701–708
Kammermeier H, Schmidt P, Jüngling E (1982) Free energy change of ATP-hydrolysis: a causal factor of early hypoxic failure of the myocardium? J Mol Cell Cardiol 14: 267–277
Jacobus WE, Pores IH, Lucas SK, Weisfeldt ML, Flaherty JT (1982) Intracellular acidosis and contractility in normal and ischemic hearts examined by 31p NMR. J Mol Cell Cardiol 14: 13–20
Kentish JC (1986) The effects of inorganic phosphate and creatine phophate on the force production in skinned muscle from rat vesicle. J Physiol 370: 585–604
Krause S, Hess ML (1984) Characterization of cardiac sarcoplasmic reticulum dysfunction during short-term, normothermic, global ischemia. Circ Res 55: 176–184
Koretsune Y, Corretti MC, Kusuoka H, Marban E (1991) Mechanism of early ischemic contractile failure. Circ Res 68: 255–262
Gallagher KP, Kumada T, Koziol JA, McKown MD, Kemper WS, Ross J Jr (1980) Significance of regional wall thickening abnormalities relative to transmural myocardial perfusion in anesthetized dogs. Circulation 62: 1266–1274
Vatner SF (1980) Correlation between acute reductions in myocardial blood flow and function in conscious dogs. Circ Res 47: 201–207
Ross J Jr (1989) Mechanisms of regional ischemia and antianginal drug action during exercise. Prog Cardiovasc Dis 31: 455–466
Ross J Jr (1991) Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 83: 1076–1083
Matsuzaki M, Gallagher KP, Kemper WS, White F, Ross J Jr (1983) Sustained regional dysfunction produced by prolonged coronary stenosis: gradual recovery after reperfusion. Circulation 68: 170–182
Fedele FA, Gewirtz H, Capone RJ, Sharaf B, Most AS (1988) Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. Circulation 78: 729–735
Pantely GA, Malone SA, Rhen WS, Anselone CG, Arai A, Bristow J, Bristow JD (1990) Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res 67: 1481–1493
Arai AE, Pantely GA, Anselone CG, Bristow J, Bristow JD (1991) Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res 69: 1458–1469
Schulz R, Guth BD, Pieper K, Martin C, Heusch G (1992) Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res 70: 1282–1295
Guth BD, Schulz R, Heusch G (1993) Time course and mechanisms of contractile dysfunction during acute myocardial ischemia. Circulation 87 [Suppl IV]:IV35–IV42
Schulz R, Miyazaki S, Miller M, Thaulow E, Heusch G, Ross J Jr, Guth BD (1989) Consequences of regional inotropic stimulation of ischemic myocardium on regional myocardial blood flow and function in anesthetized swine. Circ Res 64: 1116–1126
Schulz R, Rose J, Martin C, Brodde 0E, Heusch G (1993) Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation 88: 684–695
Rose J, Schulz R, Martin C, Heusch G (1993) Postejection wall thickening as a marker of successful short-term hibernation. Cardiovasc Res 27: 1306–1311
Rahimtoola SH (1982) Coronary bypass surgery for chronic angina–1981. Circulation 65: 225–241
Rahimtoola SH (1989) The hibernating myocardium. Am Heart J 117: 211–221
Tillisch J, Brunken R, Marshall R, Schwaier M, Mandelkern M, Phelps M, Schelbert H (1986) Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 314: 884–888
Wolpers HG, Schwaiger M (1990) Metabolic imaging of ischemic heart disease by positron emission tomography. In: Heusch G (ed) Pathophysiology and rational pharmacotherapy of myocardial ischemia. Steinkopff, Springer, Darmstadt New York, pp 59–81
Marwick TH, Maclntyre WJ, Lafont A, Nemec JJ, Salcedo EE (1992) Metabolic response of hibernating and infarcted myocardium to revascularization. A follow-up study of regional perfusion, function, and metabolism. Circulation 85: 1347–1353
Flameng W, Suy R, Schwarz F, Borgers M, Piessens J, Thone F, van Ermen H, de Geest H (1981) Ultrastructural correlates of left ventricular contraction abnormalities in patients with chronic ischemic heart disease: determinants of reversible segmental asynergy postrevascularization surgery. Am Heart J 102: 846–857
Vonoverschelde JLJ, Wijns W, Depre C, Essamri B, Heyndrickx GR, Borgers M, Bol A, Melin JA (1993) Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium. Circulation 87: 1513–1523
Bolli R (1992) Myocardial „Stunning“ in man. Circulation 86: 1671–1691
Nayler WG, Elz JS, Buckley DJ (1988) The stunned myocardium: effect of electrical and mechanical arrest and osmolarity. Am J Physiol 254: H60 - H69
Kusuoka H, Porterfield JK, Weisman HF, Weisfeldt ML, Marban E (1987) Pathophysiology and pathogenesis of stunned myocardium: depressed Cat` activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. J Clin Invest 79: 950–961
Lange R, Ware J, Kloner RA (1984) Absence of a cumulative deterioration of regional function during three repeated 5 or 15 minute coronary occlusions. Circulation 69: 400–408
Nicklas JM, Becker LC, Bulkley BH (1985) Effects of repeated brief coronary occlusion on regional left ventricular function and dimension in dogs. Am J Cardiol 56: 473–478
Thaulow E, Guth BD, Heusch G, Gilpin E, Schulz R, Kröger K, Ross J Jr (1989) Characteristics of regional myocardial stunning after exercise in dogs with chronic coronary stenosis. Am J Physiol 257: H113 - H119
Kloner RA, Allen J, Cox TA, Zheng Y, Ruiz CE (1991) Stunned left ventricular myocardium after exercise treadmill testing in coronary artery disease. Am J Cardiol 68: 329–334
Arnold JMO, Braunwald E, Sandor T, Kloner RA (1985) Inotropic stimulation of reperfused myocardium with dopamine: effects on infarct size and myocardial function. J Am Coll Cardiol 6: 1036–1044
Arnold JMO, Antman EM, Przyklenk K, Braunwald E, Sandor T, Vivaldi MT, Schoen FJ, Kloner RA (1987) Differential effects of reperfusion on incidence of ventricular arrhythmias and recovery of ventricular function at 4 days following coronary occlusion. Am Heart J 113: 1055–1065
Przyklenk K, Patel B, Kloner RA (1987) Diastolic abnormalities of postischemic „stunned“ myocardium. Am J Cardiol 60: 1211–1213
Charlat ML, O’Neill PG, Hartley CJ, Roberts R, Bolli R (1989) Prolonged abnormalities of left ventricular diastolic wall thinning in the „stunned“ myocardium in conscious dogs: time course and relation to systolic function. J Am Coll Cardiol 13: 185–194
Ehring T, Schulz R, Schipke JD, Heusch G (1992) Diastolic dysfunction of stunned myocardium. Am J Cardiovasc Pathol 4: 277–285
Zhao M, Zhang H, Robinson TF, Factor SM, Sonnenblick EH, Eng C (1987) Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional („stunned“) but viable myocardium. J Am Coll Cardiol 10: 1322–1334
Charney RH, Takahashi S, Zhao M, Sonnenblick EH, Eng C (1992) Collagen loss in the stunned myocardium. Circulation 85: 1483–1490
Whittaker P, Boughner DR, Kloner RA, Przyklenk K (1991) Stunned myocardium and myocardial collagen damage: differential effects of single and repeated occlusions. Am Heart J 121: 434–441
Ehring T, Heusch G (1990) Left ventricular asynchrony: an indicator of regional myocardial dysfunction. Am Heart J 120: 1047–1057
Heusch G, Guth BD, Gilpin E, Oudiz R, Matsuzaki M, Ross J Jr (1987) Determinants of recovery of regional contractile function after exercise-induced ischemia in conscious dogs. Fed Proc 46: 834 (Abstr)
Bolli R, Zhu W-X, Thornby JI, O’Neill PG, Robets R (1988) Time course and determinants of recovery of function after reversible ischemia in a conscious dogs. Am J Physiol 254: H102 - H114
Bolli R, Patel BS, Hartley CJ, Thornby JI, Jeroudi MO, Roberts R (1989) Nonuniform transmural recovery of contractile function in stunned myocardium. Am J Physiol 257: H375 - H385
Kusuoka H, Koretsune Y, Chacko VP, Weisfeldt ML, Marban E (1990) Excitation-contraction coupling in postischemic myocardium. Does failure of activator Cam’ transients underlie stunning? Circ Res 66: 1268–1276
Bolli R (1988) Oxygen-derived free radicals and postischemic myocardial dysfunction („stunned myocardium“). J Am Coll Cardiol 12: 239–249
Bolli R, Jeroudi MO, Patel BS, DuBose CM, Lai EK, Roberts R, McCay PB (1989) Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. Proc Natl Acad Sci USA 86: 4695–4699
Krause SM, Jacobus WE, Becker LC (1989) Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic „stunned“ myocardium. Circ Res 65: 526–530
DeBoer LWV, Ingwall JS, Kloner RA, Braunwald E (1980) Prolonged derangements of canine myocardial purine metabolism after a brief coronary artery occlusion not associated with anatomic evidence of necrosis. Proc Natl Acad Sci USA 77: 5471–5475
Swain JL, Sabina RL, McHale PA, Greenfiled JC, Holmes EW (1982) Prolonged myocardial nucleotide depletion after brief ischemia in the open-chest dog. Am J Physiol 242: H818 - H826
Hoffmeister HM, Mauser M, Schaper W (1985) Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium. Basic Res Cardiol 80: 445–458
Ito BR, Tate H, Kobayashi M, Schaper W (1987) Reversibly injured, postischemic canine myocardium retains normal contractile reserve. Circ Res 61: 834–846
Becker LC, Levine JH, DiPaula AF, Guarnieri T, Aversano T (1986) Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation. J Am Coll Cardiol 7: 580–589
Schäfer S, Heusch G (1990) Recruitment of a time-dependent inotropic reserve by postextrasystolic potentiation in normal and reperfused myocardium. Basic Res Cardiol 85: 257–269
Ehring T, Heusch G (1991) Postextrasystolic potentiation does not distinguish ischaemic from stunned myocardium. Pfluegers Arch 418: 453–461
Mercier JC, Lando U, Kanmatsuse K, Ninomiya K, Meerbaum S, Fishbein MC, Swan HJC, Ganz W (1982) Divergent effects of inotropic stimulation on the ischemic and severely depressed reperfused myocardium. Circulation 66: 397–400
Ellis SG, Wynne J, Braunwald E, Henschke CI, Sandor T, Kloner RA (1984) Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation. Am Heart J 107: 1319
Bolli R, Zhu W-X, Myers ML, Hartley CJ, Roberts R (1985) Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent deterioration. Am J Cardiol 56: 964–968
Heusch G, Schäfer S, Kröger K (1988) Recruitment of inotropic reserve in „stunned“ myocardium by the cardiotonic agent AR-L 57. Basic Res Cardiol 83: 602–610
Schäfer S, Linder C, Heusch G (1990) Xamoterol recruits an inotropic reserve in the acutely failing, reperfused canine myocardium without detrimental effects on its subsequent recovery. Naunyn Schmiedebergs Arch Pharmacol 342: 206–213
Ambrosio G, Jacobus WE, Bergmann CA, Weisman HF, Becker LC (1987) Preserved high energy phosphate metabolic reserve in globally stunned hearts despite reduction of basal ATP content and contractility. J Mol Cell Cardiol 19: 953–964
Görge G, Papageorgiou I, Lerch R (1990) Epinephrine-stimulated contractile and metabolic reserve in postischemic rat myocardium. Basic Res Cardiol 85: 595–605
Dart AM, Schömig A, Dietz R, Mayer E, Kübler W (1984) Release of endogenous catecholamines in the ischemic myocardium of the rat, pt B: Effect of sympathetic nerve stimulation. Circ Res 55: 702–706
Ciuffo AA, Ouyang P, Becker LC, Levin L, Weisfeldt ML (1985) Reduction of sympathetic inotropic response after ischemia in dogs. Contributor to stunned myocardium. J Clin Invest 75: 1504–1509
Heusch G, Frehen D, Kröger K, Schulz R, Thämer V (1988) Integrity of sympathetic neurotransmission in stunned myocardium. J Appl Cardiol 3: 259–272
Bolli R (1991) Oxygen-derived free radicals and myocardial reperfusion injury: an Overview. Cardiovasc Drugs Ther 5: 249–268
Hearse DJ (1991) Stunning: a radical review. Cardiovasc Drugs Ther 5: 853–876
Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB (1988) Demonstration of free radical generation in „stunned“ myocardium of intact dogs with the use of the spin trap a-phenyl Ntert-butyl nitrone. J Clin Invest 82: 476–485
Bolli R, Jeroudi MO, Patel BS, Aruoma OI, Halliwell B, Lai EK, McCay PB (1989) Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial „stunning“ is a manifestation of reperfusion injury. Circ Res 65: 607–622
Bolli R, Patel BS, Zhu W-X, O’Neill PG, Hartley CJ, Charlat ML, Roberts R (1987) The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction. Am J Physiol 253: H1372 - H1380
Bolli R, Patel BS, Jeroudi MO, Li X-Y, Triana JF, Lai EK, McCay PB (1990) Iron-mediated reactions upon reperfusion contribute to myocardial „stunning“. Am J Physiol 259: H1901- H1911
Bolli R, Zhu W-X, Hartley CJ, Michael LH, Repine JE, Hess ML, Kukreja RC, Roberts R (1987) Attenuation of dysfunction in the postischemic „stunned“ myocardium by dimethylthiourea. Circulation 76: 458–468
Myers ML, Bolli R, Lekich RF, Hartley CJ, Roberts R (1986) N-2-mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia. J Am Coll Cardiol 8: 1161–1168
Gross GJ, Farber NE, Hardman HF, Warltier DC (1986) Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs. Am J Physiol 250: H372 - H377
Jeroudi MO, Triana FJ, Patel BS, Bolli R (1990) Effects of superoxide dismutase and catalase, given separately, on myocardial stunning. Am J Physiol 259: H889 - H901
Triana JF, Li X-Y, Jamaluddin U, Thornby JI, Bolli R (1991) Postischemic myocardial „stunning“. Circ Res 69: 731–747
Farber NE, Pieper GM, Thomas JP, Gross GJ (1988) Beneficial effects of iloprost in the stunned canine myocardium. Circ Res 62: 204–215
Przyklenk K, Kloner RA (1991) Angiotensin converting enzyme inhibitors improve contractile function of stunned myocardium by different mechanisms of action. Am Heart J 121: 1319–1330
Lee H-C, Smith N, Mohabir R, Clusin WT (1987) Cytosolic calcium transients from the beating mammalian heart. Proc Natl Acad Sci USA 84: 7793–7797
Steenbergen C, Murphy E, Levy L, London RE (1987) Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ Res 60: 700–707
Tani M, Neely JR (1989) Role of intracellular Na’ in Ca’ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Circ Res 65: 1045–1056
Kitakaze M, Weisman HF, Marban E (1988) Contractile dysfunction and ATP depletion after transient calcium overload in perfused ferret hearts. Circulation 77: 685–695
Heusch G (1992) Myocardial stunning: a role for calcium antagonists during ischaemia? Cardiovasc Res 26: 14–19
van Amsterdam FT, Punt NC, Haas M, Zaagsma J (1990) Calcium antagonists show two modes of protection in ischemic heart failure. J Pharmacol Exp Ther 253: 277–283
Dunlap ED, Matlib MA, Millard RW (1989) Protection of regional mechanics and mitochondrial oxidative phosphorylation by amlodipine in transiently ischemic myocardium. Am J Cardiol 64:84 I-93 I
Przyklenk K, Kloner RA (1988) Effect of verapamil on postischemic „stunned“ myocardium: importance of the timing of treatment. J Am Coll Cardiol 11: 614–623
Warltier DC, Gross GJ, Brooks HL, Preuss KC (1988) Improvement of postischemic, contractile function by the calcium channel blocking agent nitrendipine in conscious dogs. J Cardiovasc Pharmacol 12 (Suppl 4): S120–5124
Jeremy RW, Stahl L, Gillinov M, Litt M, Aversano TR, Becker LC (1989) Preservation of coronary flow reserve in stunned myocardium. Am J Physiol 256: H1303 - H1310
Laxson DD, Homans DC, Dai X-Z, Sublett E, Bache RJ (1989) Oxygen consumption and coronary reactivity in postischemic myocardium. Circ Res 64: 9–20
Bolli R, Triana JF, Jeroudi MO (1990) Prolonged impairment of coronary vasodilation after reversible ischemia. Circ Res 67: 332–343
Stahl LD, Aversano TR, Becker LC (1986) Selective enhancement of function of stunned myocardium by increased flow. Circulation 74: 843–851
Schulz R, Guth BD, Heusch G (1991) No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs: evidence against the Gregg phenomenon. Circulation 83: 1390–1403
Schulz R, Janssen F, Guth BD, Heusch G (1991) Effect of coronary hyperperfusion on regional myocardial function and oxygen consumption of stunned myocardium in pigs. Basic Res Cardiol 86: 534–543
Lamping KA, Gross GJ (1985) Improved recovery of myocardial segment function following a short coronary occlusion in dogs by nicorandil, a potential new antianginal agent, and nifedipine. J Cardiovasc Pharmacol 7: 158–166
Przyklenk K, Ghafari GB, Eitzman DT, Kloner RA (1989) Nifedipine administered after reperfusion ablates systolic contractile dysfunction of postischemic „stunned“ myocardium. J Am Coll Cardiol 13: 1176–1183
Taylor AL, Golino P, Eckels R, Pastor P, Buja M, Willerson JT (1990) Differential enhancement of postischemic segmental systolic thickening by diltiazem. J Am Coll Cardiol 15: 737–747
Ehring T, Böhm M, Heusch G (1992) The calcium antagonist nisoldipine improves the functional recovery of reperfused myocardium only when given before ischemia. J Cardiovasc Pharmacol 20: 63–74
Du Toit EF, Owen P, Opie LH (1990) Attenuated reperfusion stunning with a calcium channel antagonist or internal calcium blocker in the isolated perfused rat heart. J Mol Cell Cardiol 22 (Suppl III): S 58 (Abstr)
Guarnieri T (1989) Direct measurement of [Ca2+]i in early and late reperfused myocardium. Circulation 80 (Suppl II): II-241 (Abstr)
Janero DR, Burghardt B (1989) Antiperoxidant effects of dihydropyridine calcium antagonists. Biochem Pharmacol 38: 4344–4348
Koller PT, Bergmann SR (1989) Reduction of lipid peroxidation in reperfused isolated rabbit hearts by diltiazem. Circ Res 65: 838–846
Mak IT, Weglicki WB (1990) Comparative antioxidant activities of propranolol, nifedipine, verapamil, and dilziazem against sarcolemmal membrane lipid peroxidation. Circ Res 66: 1449–1452
Du Toit EF, Opie LH (1992) Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at the onset of reperfusion. Circ Res 70: 960–967
Opie L (1992) Myocardial stunning: a role for calcium antagonists during reperfusion. Cardiovasc Res 26: 19–24
Nayler WG (1991) Second generation of calcium antagonists. Springer, Berlin Heidelberg New York, pp 1–226
Przyklenk K, Kloner RA (1992) Letter to the editor: Calcium antagonists and the stunned myocardium: a role during ischemia? A role during reperfusion? Cardiovasc Res 26: 82–84
Murry CE, Jennings RB, Reimer KA (1991) New insights into potential mechanisms of ischemic preconditioning. Circulation 84: 442–445
Murry CE, Richard VJ, Reimer KA, Jennings RB (1990) Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 66: 913–931
Ovize M, Kloner RA, Hale SL, Przyklenk K (1992) Coronary cyclic flow variations „precondition“ ischemic myocardium. Circulation 85: 779–789
Li GC, Vasquez JA, Gallagher KP, Lucchesi BR (1990) Myocardial protection with preconditioning. Circulation 82: 609–619
Gross GJ, Auchampach JA (1992) Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 70: 223–233
Murry CE, Richard VJ, Jennings RB, Reimer KA (1991) Myocardial protection is lost before contractile function recovers from ischemic preconditioning. Am J Physiol 260: H796 - H804
Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P (1993) Regional ischemic „Preconditioning“ protects remote virigin myocardium from subsequent sustained coronary occlusion. Circulation 87: 893–899
Kida M, Fujiwara H, Ishida M, Kawai C, Ohura M, Miura I, Yabuuchi Y (1991) Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation 84: 2495–2503
Miura T, Goto M, Urabe K, Endoh A, Shimamoto K, Iimura O (1991) Does myocardial stunning contribute to infarct size limitation by ischemic preconditioning? Circulation 84: 2504–2512
Rohmann S, Schott RJ, Harting J, Schaper W (1991) Ischemic preconditioning is not a function of stunned myocardium. J Mol Cell Cardiol 23 (Suppl V ): 71 (Abstr)
Ovize M, Przyklenk K, Hale SL, Kloner RA (1992) Preconditioning does not attenuate myocardial stunning. Circulation 85: 2247–2254
Iwamoto T, Miura T, Adachi T, Noto T, Ogawa T, Tsuchida A, Iimura O (1991) Myocardial infarct size-limiting effect of ischemic preconditioning was not attenuated by oxygen free-radical scavengers in the rabbit. Circulation 83: 1015–1022
Turrens JF, Thornton J, Barnard ML, Snyder S, Liu G, Downey JM (1992) Protection from reperfusion injury by preconditioning hearts does not involve increase antioxidant defenses. Am J Physiol 262: H585 - H589
Thornton J, Striplin S, Liu GS, Swafford A, Stanley AWH, van Winkle DM, Downey JM (1990) Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. Am J Physiol 259: H1822 - H1825
Li Y, Kloner RA (1992) Cardioprotective effects of ischaemic preconditioning are not mediated by prostanoids. Cardiovasc Res 26: 226–231
Mullane K (1992) Myocardial preconditioning. Part of the adenosine revival. Circulation 85: 845–847
Nichols CG, Lederer WJ (1991) Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol 261: H1675 - H1686
Liu GS, Thornton J, van Winkle DM, Stanley AWH, Olsson RA, Downey JM (1991) Protection against infarction afforded by preconditioning is mediated by Al adenosine receptors in rabbit heart. Circulation 84: 350–356
Thornton JD, Liu GS, Olsson RA, Downey JM (1992) Intravenous pretreatment with Al-selective adenosine analogues protects the heart against infarction. Circulation 85: 650–665
Tsuchida A, Miura T, Miki T, Shimamoto K, Iimura O (1992) Role of adenosine receptor activation in myocardial infarct size limitation by ischemic preconditioning. Cardiovasc Res 26: 456–461
van Wagoner DR (1993) Mechanosensitive gating of atrial ATP-sensitive potassium channels. Circ Res 72: 973–983
Shiki K, Hearse DJ (1987) Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias. Am J Physiol 253: H1470 - H1476
Hagar JM, Hale SL, Kloner RA (1991) Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ Res 68: 61–68
Li Y, Whittaker P, Kloner RA (1992) The transient nature of the effect of ischemic preconditioning on myocardial infarct size and ventricular arrythmia. Am Heart J 123: 346–353
Miyazaki T, Zipes DP (1989) Protection against autonomic denervation following acute myocardial infarction by preconditioning ischemia. Circ Res 64: 437–448
Deutsch E, Berger M, Kussmaul WG, Hirshfeld JW Jr, Herrmann HC, Laskey WK (1990) Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features. Circulation 82: 2044–2051
Osakada G, Kumada T, Gallagher KP, Kemper WS, Ross J Jr (1981) Reduction of exercise-induced ischemic regional myocardial dysfunction by verapamil in conscious dogs. Am Heart J 101: 707–712
Weiss RG, Bottomley PA, Hardy CJ, Gerstenblith G (1990) Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. N Engl J Med 323: 1593–1600
Schelbert HR (1991) Positron emission tomography for the assessment of myocardial viability. Circulation 84 (Suppl I): I-122-I-131
Piérard LA, Landsheere CM de, Berthe C, Rigo P, Kulbertus HE (1990) Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy: comparison with positron emission tomography. J Am Coll Cardiol 15: 1021–1031
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Baumgart, D., Heusch, G. (1995). Pathophysiologie der Myokardischämie. In: Ahnefeld, F.W., Dick, W., Erdmann, E. (eds) Herz- und kreislaufwirksame Medikamente in Anästhesie, Intensiv- und Notfallmedizin. Klinische Anästhesiologie und Intensivtherapie, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78777-5_1
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