Use of Neutron Therapy in the Management of Locally Advanced Nonresectable Primary or Recurrent Rectal Cancer

  • R. Engenhart-Cabillic
  • J. Debus
  • F. J. Prott
  • R. Pötter
  • K. H. Höver
  • N. Breteau
  • A. Krüll
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 150)

Abstract

Inoperable locally advanced or inoperable recurrent rectal cancer is a difficult problem. Tenesmus, discharge, bleeding and pelvic pain are frequently present and often are associated with infiltration of the sacral plexus. The value of radiotherapy in managing such patients is being appreciated, although up to 40% of the treated patients have no symptomatic response. Improvement in tumor response and control has been scored through efforts to overcome the radioresistance of the hypoxic tumor cells by neutron irradiation. This article is an account of the activity of neutron radiotherapy in such patients. Over 350 patients were entered in studies comparing neutrons used alone and neutrons used in a mixed-beam treatment schedule. At present no therapeutic gain for long-lasting survival has been achieved; however, local control and pain improvement seems to be better with neutrons than with photons.

Keywords

Toxicity Adenocarcinoma Oncol Perforation Fluorouracil 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1998

Authors and Affiliations

  • R. Engenhart-Cabillic
    • 1
  • J. Debus
    • 2
  • F. J. Prott
    • 3
  • R. Pötter
    • 3
  • K. H. Höver
    • 2
  • N. Breteau
    • 4
  • A. Krüll
    • 5
  1. 1.Department of RadiotherapyMedical Radiology CenterMarburgGermany
  2. 2.Department of Radiation OncologyGerman Cancer Research CenterHeidelbergGermany
  3. 3.Department of Radio-oncologyUniversity of MünsterMünsterGermany
  4. 4.Centre Hospitalier Régional OrléansCyclotron du CNRS OrléansOrléans cedex 2France
  5. 5.Department of RadiooncologyUniversity of HamburgGermany

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