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Skin Cancer and Warts in Immunosuppressed Renal Transplant Recipients

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Skin Cancer: Basic Science, Clinical Research and Treatment

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 139))

Abstract

Non-melanoma skin cancer (NMSC) is increasingly recognised as a complication of long-term immunosuppression and has been particularly studied in renal transplant recipients (RTR). A population study of renal transplant recipients has been performed with analysis of those features contributing to a high rate of detection of NMSC, such that 40% patients with fair skin have NMSC 5 years after transplantation, 90% of the total patient population have warts 5 years after transplantation, many being atypical and in sun-exposed sites. Therefore, contributory factors in these patients include not only the global immunosuppression, ultraviolet radiation (UVR)-induced mutagenesis and photoimmunosuppression, but also the widespread presence of human papillomavirus (HPV) infection, including the unusual epidermodysplasia verruciformis (EV)-associated cutaneous oncogenic HPV.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Royal London Hospital Trust, London, E1 1BB, UK

    I. M. Leigh & M. T. Glover

  2. ICRF Skin Tumour Laboratory, London Hospital Medical College, 56 Ashfield Street, London, E1 2BL, UK

    I. M. Leigh & M. T. Glover

Authors
  1. I. M. Leigh
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  2. M. T. Glover
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Editors and Affiliations

  1. University Department of Dermatology Medical Centre Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Claus Garbe , Stefan Schmitz  & Constantin E. Orfanos ,  & 

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© 1995 Springer-Verlag Berlin · Heidelberg

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Leigh, I.M., Glover, M.T. (1995). Skin Cancer and Warts in Immunosuppressed Renal Transplant Recipients. In: Garbe, C., Schmitz, S., Orfanos, C.E. (eds) Skin Cancer: Basic Science, Clinical Research and Treatment. Recent Results in Cancer Research, vol 139. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78771-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-78771-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78773-7

  • Online ISBN: 978-3-642-78771-3

  • eBook Packages: Springer Book Archive

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