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bcl-1, bcl-2, p53, c-myc, and lyt-10 Analysis in Cutaneous Lymphomas

  • S. A. Garatti
  • E. Roscetti
  • D. Trecca
  • N. S. Fracchiolla
  • A. Neri
  • E. Berti
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 139)

Abstract

In the present study we investigated the pathogenetic role of c-myc, bcl-2, and lyt-10 oncogenes, bcl-1 locus, and p53 suppressor gene in a representative panel of cutaneous lymphomas, including 25 cases of cutaneous B cell lymphoma (CBCL) and 29 cases of cutaneous T cell lymphoma (CTCL). In our analysis four cases of CBCL were found rearranged for bcl-2 and two for the bcl-1 locus. Two cases of CTCL and one case of CBCL were found rearranged for lyt-10. No rearrangements of c-myc oncogene were found in CBCL. Analysis of p53 gene showed mutation only in one case of mycosis fungoides in tumoral stage, at codon 163 of p53 gene (TAC → CAC; Tyr → Asp). Our data suggest that in primary CBCL bcl-2 oncogenes and bcl-1 locus are rarely involved. Furthermore, in primary CTCL p53 gene is not affected at significant frequency. The occurrence of p53 mutation in a patient affected by mycosis fungoides in tumoral stage may represent an involvement of p53 gene in tumor progression of CTCL, a finding observed in several types of human cancer.

Keywords

Anaplastic Large Cell Lymphoma Mycosis Fungoides Cutaneous Lymphoma Rearrange Band Germline Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1995

Authors and Affiliations

  • S. A. Garatti
    • 1
    • 2
  • E. Roscetti
    • 1
    • 2
  • D. Trecca
    • 1
  • N. S. Fracchiolla
    • 1
  • A. Neri
    • 1
  • E. Berti
    • 2
  1. 1.Laboratorio di Ematologia Sperimentale e Genetica molecolare, Servizio di EmatologiaIstituto di Scienze MedicheMilanItaly
  2. 2.Istituto di Scienze DermatologicheUniversità degli Studi di Milano, Ospedale Maggiore IRCCSMilanItaly

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