Sensory Neurons and Plasticity: The Role of Immediate Early Genes

  • Carmen De Felipe
  • Robert Jenkins
  • Stephen P. Hunt
Conference paper
Part of the NATO ASI Series book series (volume 79)


The protooncogenes c-fos and c-jun, code for transcriptionally active nuclear proteins that may play a central role in the long term response of neurons and glial cells to stimulation and damage. Fos and Jun are also ‘immediate early genes’ (IEGs) which were originally described as a class of genes that were rapidly induced in cells stimulated with growth factors.11


Nerve Growth Factor Dorsal Root Ganglion Sciatic Nerve Schwann Cell Sensory Neuron 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Carmen De Felipe
    • 1
  • Robert Jenkins
    • 1
  • Stephen P. Hunt
    • 1
  1. 1.MRC Laboratory of Molecular BiologyDivision of NeurobiologyCambridgeUK

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