Abstract
The protooncogenes c-fos and c-jun, code for transcriptionally active nuclear proteins that may play a central role in the long term response of neurons and glial cells to stimulation and damage. Fos and Jun are also ‘immediate early genes’ (IEGs) which were originally described as a class of genes that were rapidly induced in cells stimulated with growth factors.11
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References
Angel, P., Hattori, K., Smeal, T. and Karin, M. (1988) The jun protooncogene is positively autoregulated by its product, Jun/AP-1. Cell 55, 875–885.
Auwerx, J. and Sassoni-Corsi, P. (1991) IP-1: A dominant inhibitor of fos/jun whose activity is modulated by phosphorylation. Cell 64, 983–993.
Baichwal, V.R. and Tjian, R. (1990) Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun. Cell 63, 815–825.
Bedi, K.S., Winter, J., Berry, M. and Cohen, J. (1991) Adult rat dorsal root ganglion neurons extend neurites on predegenerated but not on normal peripheral nerves in vitro. Eur. J. Neurosci 4, 193–200.
Benbrook, D.M. and Jones, N.C. (1990) Heterodimer formation between CREB and JUN proteins. Oncogene 5, 295–302.
Bos, T.J., F.S. Monteclaro, F., Mitsuobu, F., Ball, A.R., Chang, C.H.W., Nishimura, T. and Vogt, P.K. (1990) Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and non-coding sequences. Genes and Development 4, 1677–1687.
Carroll, S.L., Silos-Santiago, I., Frese, S.E., Ruit, K.G., Milbrandt, J. and Snider, W.D. (1992) Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero. Neuron 9, 779–788.
Castellazi, M., Loiseau, L., Piu, F. and Sergeant, A. (1993) Chimeric c-Jun containing an heterologous homodimerization domain transforms primary chick embryo fibroblasts. Oncogene 8, 1149–1160.
Castellazzi, M., Spyrou, G., La Vista, N., Dangy, J.-P., Piu, F., Yaniv M. and Brun, G. (1991) Overexpression of c-jun, junB, or junD. Proc. Natl. Acad. Sci, USA 88, 8890–8894.
Chao, M.V. (1992) Neurotrophin receptors: A window into neural differentiation.Neuron 9, 583–593.
Cochran, B.H., Reffel A.C., and Stiles, C.D. (1983) Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 33, 939–947.
Cragg, B. (1970). What is the signal for chromatolysis? Brain Res. 23, 1–21.
De Felipe, C., Jenkins, R., O’Shea, R., Williams, T.S.C. and Hunt, S.P. (1993) The role of immediate early genes in the regeneration of the central nervous system. Adv. in Neurol. New York, Raven Press. 263–271.
De Groot, R.P., Kruyt, F.A.E., Van Der Saag, P.T. and Kruijer, W. (1990). Ectopic expression of c-jun leads to differentiation of P19 embryonal carcinoma cells. The EMBO Journal 9, 1831–1837.
Devor, M., Schonfield, D., Seltzer, Z., and Wall, P.D. (1979) Two modes of cutaneous representation following peripheral nerve injury. J Comp. Neurol. 185, 211–220.
Diamond, M.I., Miner, J.N., Yoshinaga, S.K. and Yamamoto, K.R. (1990) Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element. Science 249, 1266–1271.
Dubner, R. and Ruda, M.A. (1992) Activity dependant neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15, 96–103.
Ernfors, P. and Persson, H. (1991) Developmentally regulated expression of HDNF/NT-3 mRNA in rat spinal cord motoneurons and expression of BDNF mRNA in embryonic dorsal root ganglion. Eur. J. Neurosci. 3:, 953–961.
Fitzgerald, M., Wall, P.D., Goedert, M. and Emson, P.C. (1985) Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section. Brain Res. 332, 131–141.
Foulkes, N.S., Laoide, B.M., Schlotte F. and Sassoni-Corsi, P. (1991) Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression. Proc. Natl. Acad Sci, USA 88, 5448–5452.
Greenberg, S.E. and Lasek, R.J. (1988) Neurofilament protein synthesis in DRG neurons decreases more after peripheral axotomy than central axotomy. J. Neurosci 8, 1739–1746.
Hendry, I.A., Thoenen, H. and Iversen, L.L. (1974) The retrograde axonal transport of nerve growth factor. Brain Res. 68, 103–121.
Hunt, S.P., Pini A. and Evan, G. (1987) Induction of c-fos like protein in spinal cord neurons following sensory stimulation. Nature 328, 632–634.
Iadarola, M.J., Brady, L.S., Draisci, G. and Dubner, R. (1988) Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioural parameters and opioid receptor binding. Pain 35, 313–326.
Jackson, S.P. (1992) Regulating transcription factor activity by phosphorylation. Trends in Cell Biol. 2, 104–108.
Jenkins, R. and Hunt, S.P. (1991) Long term increases in the levels of c-jun mRNA and Jun protein like immunoreactivity in motor and sensory neurons following axon damage. Neurosci Lett 129, 107–111.
Jenkins, R., Mcmahon, S.B., Bond, A.B. and Hunt, S.P. (1993) Expression of c-Jun as a response to dorsal root and peripheral nerve section in damaged and adjacent intact primary sensory neurons in the rat. Eur. J. Neurosci. 5, 751–759.
Jenkins, R., O’Shea, R., Thomas, K.L. and Hunt, S.P. (1993) c-jun expression of immediate early genes in substantia nigra neurons following striatal 6-OHDA lesions in the rat. Neuroscience 53, 447–457.
Jenkins, R., Tetzlaff, W. and Hunt, S.P. (1993) Differential expression of immediate early genes in rubrospinal neurons following axotomy in the rat. Eur. J.Neurosci 5, 203–209.
Karin, M. and Smeal, T. (1992) Control of transcription factors by signal transduction pathways: The beginning of the end. Trends in Biochem. Sci. 17, 418–422.
Lamb, P. and Mcknight, S.L. (1991) Diversity and specificity in transcriptional regulation: The advantages of heterotypic dimerization. Trends in Biochem. Sci. 16, 417–422.
Lamph, W.W., Dwarki, V.J., Ofir, R., Montminy, M. and Verma, I.M. (1990) Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. Proc. Natl Acad. Sci. USA 87, 4320–4324.
Leah, J.D., Herdegen, T. and Bravo, R. (1991) Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat; evidence for a role in the regeneration process. Brain Res. 566, 198–207.
Lemke, G. (1990) Glial growth factors. Seminars in the Neurosciences 2, 437–443.
Lindsay, R. M. (1988) Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J. Neurosci. 8, 2394–2405.
Lindsay, R.M. and Harmar, A.J. (1989) Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 337, 362–364.
Lindsay, R.M., Lockett, C., Sternberg, J. and Winter, J. (1989) Neuropeptide expression in cultures of adult sensory neurons: Modulation of substance P and calcitonin gene-related peptide levels by nerve growth factor. Neuroscience 33, 53–65.
Lu, X. and Richardson, P.M. (1991) Inflammation near the nerve cell body enhances axonal regeneation. J. Neurosci. 11, 972–978.
Maki, Y., T.J. Bos, Davies, C., Starbuck, M. and Vogt, P.K. (1987) Avian sarcoma virus 17 carries the jun oncogene. Proc. Natl Acad. Sci. USA 84, 2848–2852.
Martini, R. and Schachner, M. (1988) Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM and myelin associated glycoprotein) in regenerating adult mouse sciatic nerve. J. Cell Biol. 106, 1735–1746.
Mcnaughton, L.A. and Hunt, S.P. (1992) Regulation of gene expression in astrocytes by excitatory amino acids. Molec. Brain Res. 16, 261–266.
Meyer, M., Matsuoka, I., Wetmore, C., Olson L. and Thoenen, H. (1992) Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: Different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119, 45–54.
Palmer, J.A., De Felipe, C., and Hunt, S.P. (1993) The expression of c-jun is correlated with the facilitation of neurite outgrowth. Brain Res. Assoc. Abstr. 10, 8.
Richardson, P. and Issa, V.M.K. (1984) Peripheral injury enhances central regeneration of primary sensory neurons. Nature 309, 791–793.
Sheng, M. and Greenberg, M.E. (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4, 477–485.
Sleigh, M.J. (1992) Differentiation and proliferation in mouse embryonal carcinoma cells. BioEssays 14, 769–775.
Sommervaille, T., Reynolds, M.L. and Woolf, C.J. (1991) Time-dependant differences in the increase in GAP-43 expression in dorsal root ganglion cells after peripheral axotomy. Neuroscience 45, 213–230.
Taniuchi, M., Clark, H.B. Schweitzer, J.B. and Johnson, E.M. (1988) Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: Ultrastructural location, suppression by axonal contact, and binding properties. J.Neurosci. 8, 664–681.
Verge, V.M.K., Merlio, J.-P., Grondin, J., Ernfors, P., Persson, H., Riopelle, R.J., Hokfelt, T. and Richardson, P.M. (1992) Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: Responses to injury and infusion of NGF. J. Neurosci 12, 4011–4022.
Verge, V.M.K., Richardson, P.M., Benoit, R. and Ropelle, R.J. (1989) Histochemical characterisation of sensory neurons with high affinity receptors for nerve growth factor. J. Neurocytol. 18, 583–591.
Verge, V.M.K., R.J. Riopelle and Richardson P.M. (1989) Nerve growth factor receptors on normal and injured sensory neurons. J. Neurosci. 9, 914–922.
Williams, T. S. C., G. I. Evan and S. P. Hunt (1990) Changing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat. Neuroscience 36, 73–81.
Wisden, W., M. L. Errington, S. Williams, S. B. Dunnett, C. Waters, D. Hitchcock, G. Evan, T. V. Bliss and S. P. Hunt (1990) Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4, 603–614.
Wong, W.-Y., L. Havarstein, I. M. Morgan and P. K. Vogt (1992) c-jun causes focus formation and anchorage-independant growth in culture but is non-tumorigenic. Oncogene 7, 2077–2080.
Woolf, C. J., M. L. Reynolds, C. Molander, C. O’Brien, R. M. Lindsay and L. I. Benowitz (1990) The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury. Neuroscience 34, 465–478.
Yamaguchi-Iwai, Y., M. Satake, Y. Murakami, M. Sakai, M. Muramatsu and Y. Ito (1990) Differentiation of F9 embryonal carcinoma cells induced by c-jun and activated c-Ha-ras oncogenes. Proc. Natl. Acad. Sci., USA 87, 8670–8674.
Yang-Yen, H.-F., R. Chiu and M. Karin (1990) Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription. The New Biologist 2, 351–361.
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De Felipe, C., Jenkins, R., Hunt, S.P. (1994). Sensory Neurons and Plasticity: The Role of Immediate Early Genes. In: Urban, L. (eds) Cellular Mechanisms of Sensory Processing. NATO ASI Series, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78762-1_19
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DOI: https://doi.org/10.1007/978-3-642-78762-1_19
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