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Cellular Mechanisms of Sensory Processing pp 217–230Cite as

Tachykinin Receptors and their Antagonists

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Part of the book series: NATO ASI Series ((ASIH,volume 79))

Abstract

Tachykinins (TKs) are a family of peptides which share the common C-terminal sequence Phe-Xaa-Gly-Leu-MetNH2. Three peptides of this family, substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) (Table I), have an established role as neurotransmitters in mammals. SP and NKA are produced through the expression of the same gene, preprotachykinin I (PPT I) while the PPT II gene encodes NKB.23,24 Two N-terminally extended forms of NKA, neuropeptide K and neuropeptide γ are also produced from the PPT I gene, but their status of neurotransmitters is not yet firmly established.

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Authors and Affiliations

  1. Department of Pharmacology, A. Menarini Pharmaceuticals, Via Sette Santi 3, 50131, Florence, Italy

    Carlo Alberto Maggi & Alessandro Lecci

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  1. Carlo Alberto Maggi
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  2. Alessandro Lecci
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  1. Sandoz Institute for Medical Research, 5 Gower Place, London, WC1E 6BN, UK

    Laszlo Urban

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© 1994 Springer-Verlag Berlin Heidelberg

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Maggi, C.A., Lecci, A. (1994). Tachykinin Receptors and their Antagonists. In: Urban, L. (eds) Cellular Mechanisms of Sensory Processing. NATO ASI Series, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78762-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-78762-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78764-5

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