Tachykinin Receptors and their Antagonists

  • Carlo Alberto Maggi
  • Alessandro Lecci
Part of the NATO ASI Series book series (volume 79)

Abstract

Tachykinins (TKs) are a family of peptides which share the common C-terminal sequence Phe-Xaa-Gly-Leu-MetNH2. Three peptides of this family, substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) (Table I), have an established role as neurotransmitters in mammals. SP and NKA are produced through the expression of the same gene, preprotachykinin I (PPT I) while the PPT II gene encodes NKB.23,24 Two N-terminally extended forms of NKA, neuropeptide K and neuropeptide γ are also produced from the PPT I gene, but their status of neurotransmitters is not yet firmly established.

Keywords

Ischemia Attenuation NMDA Capsaicin Mast 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Carlo Alberto Maggi
    • 1
  • Alessandro Lecci
    • 1
  1. 1.Department of PharmacologyA. Menarini PharmaceuticalsFlorenceItaly

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