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Intermediate filaments: regulation of gene expression and assembly

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EJB Reviews 1993

Part of the book series: EJB Reviews ((EJB REVIEWS,volume 1993))

  • 133 Accesses

Abstract

The cytoskeleton of eukaryotic cells consists of three major fibrillar networks: microfilaments (25 nm), intermediate filaments (10 nm) and microtubules (5 nm) which can be distinguished on the basis of ultrastructural and immunological properties. Microfilaments and microtubules are involved in a number of vital processes such as cell division, protoplasmic streaming, locomotion, anchorage and cellular polarity. The function of intermediate filaments (IF), however, is not fully understood yet. Only recently has progress been reported on the elucidation of some functional aspects of IF.

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Abbreviations

AP-1:

activator protein 1

AP2:

transcription factor AP2

CNS:

central nervous system

GFAP:

glial fibrillary acidic protein

HSV-1:

human sarcoma virus 1

LTK−TK− :

mouse L cells

MCF-7:

mammary carcinoma cell line MCF-7

NF:

neurofilament

NF1:

transcription factor NF1

NGF:

nerve growth factor

PC12:

rat pheochromocytoma cell line PC12

PNS:

peripheral nervous system

SV40:

simian virus 40

TK− :

thymidine-kinase-deficient

TPA:

12-O-tetradecanoylphorbol 13-acetate, VP16, HSV-1 viral trans-activator protein VP16

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  1. Department of Biochemistry, Faculty of Science, University of Nijmegen, P. O. Box 9101, NL-6500 HB, The Netherlands

    Francy A. J. M. van de Klundert, Jos M. H. Raats & Hans Bloemendal

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van de Klundert, F.A.J.M., Raats, J.M.H., Bloemendal, H. (1994). Intermediate filaments: regulation of gene expression and assembly. In: EJB Reviews 1993. EJB Reviews, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78757-7_8

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