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Regulation of vertebrate homeobox-containing genes by morphogens

  • Fulvio Mavilio
Part of the EJB Reviews book series (EJB REVIEWS, volume 1993)

Abstract

Development of a vertebrate organism entails a complex network of inductive interactions whereby cell fate is progressively specified according to a genetically determined body plan. In order to achieve development of the right structure in the right place of the embryo, positional information has to be given to individual cells throughout morphogenesis to interact with, or become part of, the gene activation program, eventually leading to the terminally differentiated state. How positional information is encoded in embryos and decoded by each cell at any given time during development is largely unknown at both cellular and molecular levels.

Keywords

Retinoic Acid Embryonal Carcinoma Cell Retinoic Acid Treatment Apical Ectodermal Ridge Paraxial Mesoderm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CNS

central nervous system

EC

embryonal carcinoma

FGF

fibroblast growth factor

HOM-C

homeotic cornplex

PGF

peptide growth factor

RA

all-trans-retinoic acid

TGF

transforming growth factor

Wnt

wingless/int-1 growth factor

ZPA

zone of polarizing activity

Genes

abd and Abd, abdominal

Antp

Antennapedia

bcd

bicoid

Dfd

deformed

En and en

engrailed

eve

evens-kipped

EVX

human even-skipped-like

Evx

mouse even-skipped-like

ftz

fushi tarazu

HOX

human homeobox-containing

Hox

mouse homeobox-containing

iab

infrabdominal

lab

labial

NvHox

newt homeobox-containing

pb

proboscipedia

Pc

polycomb

Scr

sex combs reduced

Ubx

ultrabithorax

Xhox

Xenopus homeobox-containing

zen

zerknüllt

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Copyright information

© Federation of European Biochemical Societies 1994

Authors and Affiliations

  • Fulvio Mavilio
    • 1
  1. 1.Department of Biology and BiotechnologyIstituto Scientifico H. S. RaffaeleMilanoItaly

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