Skip to main content
SpringerLink
Log in

Chronopharmacology

  • Chapter
Biologic Rhythms in Clinical and Laboratory Medicine

Abstract

Chronobiological observations lead to the hypothesis that the response of an organism to a drug may depend on the hour of administration. Virey was one of the first who suggested in 1814 that desired and un-desired effects of a drug may vary according to the time of its administration (Reinberg 1979). Later this hypothesis was validated and the toxicity and efficiency of many drugs have been shown to depend on their time of administration. Some of the mechanisms involved in the time-dependent (chronopharmaco-logical) responses are documented at the present time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Altmayer P, Groterath E, Lucker PW, Mayer D, von Mayers-bach H (1979) Zirkadiane Schwankungen pharmakologi-scher Parameter nach oraler Gabe von Hexobarbital. Arznei-mittelforschung 29:1422–1428

    CAS  Google Scholar 

  • Bauer LA, Davis R, Wilensky A, Raisys V, Levy RH (1985) Valproic acid clearance: unbound fraction and diurnal variation in young and elderly adults. Clin Pharmacol Ther 37: 697–700

    PubMed  CAS  Google Scholar 

  • Beckett AH, Rowland M (1964) Rhythmic urinary excretion of amphetamine in man. Nature 204:1203–1204

    PubMed  CAS  Google Scholar 

  • Belanger PM (1988) Chronobiological variation in the hepatic elimination of drugs and toxic chemical agents. Annu Rev Chronopharmacol 4:1–46

    CAS  Google Scholar 

  • Belanger PM, Labrecque G, Dore F (1981) Rate limiting steps in the temporal variations in the metabolism of selected drugs. Int J Chronobiol 7: 208–215

    Google Scholar 

  • Bruguerolle B (1976) Chronopharmacologie des substances cu-rarisantes. Thesis, University of Marseille

    Google Scholar 

  • Bruguerolle B (1983a) Influence de l’heure d’administration d’un medicament sur sa pharmacocinetique. Therapie 38: 223–235

    PubMed  CAS  Google Scholar 

  • Bruguerolle B (1983b) Cycle menstruel et pharmacocinetique des médicaments. J Gynecol Obstet Biol Reprod (Paris) 12: 825–827

    CAS  Google Scholar 

  • Bruguerolle B (1984a) La chronopharmacologie. Ellipses, Paris

    Google Scholar 

  • Bruguerolle B (1984b) Circadian phase dependent pharmacokinetics of disopyramide in mice. Chronobiol Int 1: 267–271

    PubMed  CAS  Google Scholar 

  • Bruguerolle B (1987a) Modifications de la pharmacocinetique de la theophylline au cours du cycle oestral chez la ratte. Pathol Biol 35:181–183

    PubMed  CAS  Google Scholar 

  • Bruguerolle B (1987b) Erythrocyte concentrations of theophylline: influence of the oestrous cycle. Med Sci Res (Biochem) 15: 263–264

    CAS  Google Scholar 

  • Bruguerolle B (1987c) Données récentes en chronopharmaco-cinetique. Pathol Biol 35: 925–934

    PubMed  CAS  Google Scholar 

  • Bruguerolle B (1989) Temporal aspects of drug absorption. In: Lemmer B (ed) Chronopharmacology cellular and biochemical interactions. Dekker, New York, pp 3–13

    Google Scholar 

  • Bruguerolle B, Isnardon R (1985) Daily variations in plasma levels of lidocaine during local anaesthesia in dental practice. Ther Drug Monit 7: 369–370

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Jadot G (1983) Influence of the hour of administration of lidocaïne on its intraerythrocytic passage in the rat. Chronobiologia 10: 295–297

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Jadot G (1985) Circadian changes in procainamide and N-acetylprocainamide kinetics in the rat. J Pharm Pharmacol 37: 654–656

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Prat M (1987) Temporal changes in bupivacaine kinetics. J Pharm Pharmacol 39:148–149

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Prat M (1988) Circadian phase dependent pharmacokinetics and acute toxicity of mepivacaine. J Pharm Pharmacol 40: 592–594

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Prat M (1989) Temporal variations in the erythrocyte permeability to bupivacaine, etidocaine and mepivacaine in mice. Life Sci 45: 2587–259

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Prat M (1990) Circadian phase dependent acute toxicity and pharmacokinetics of etidocaine in serum and brain of mice. J Pharm Pharmacol 42: 201–202

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Mesdjian E, Jadot G, Valli M, Agopian B, Bouy-ard P (1976) Variations de l’activité de diverses substances curarisantes en fonction de l’heure d’administration. Ann Anesthesiol Fr 16: 349–353

    Google Scholar 

  • Bruguerolle B, Mesdjian E, Valli M, Jadot G, Agopian B, Bouy-ard P (1977) Etude chronopharmacologique du bromure de pancuronium chez le rat. J Pharmacol 8: 49–58

    CAS  Google Scholar 

  • Bruguerolle B, Mesdjian E, Valli M, Blanc MC, Jadot G, Vig-Non E, Bouyard P (1978a) Etude chronopharmacologique de l’ alfatésine chez le rat mâle. J Pharmacol 9: 53–64

    CAS  Google Scholar 

  • Bruguerolle B, Valli M, Jadot G, Rakoto IC, Bouyard P (1978b) Chronopharmacologie du pancuronium chez le rat anesthésié à l’aide de CT1341(alfatésine). C R Soc Biol [D] (Paris) 172: 498–504

    CAS  Google Scholar 

  • Bruguerolle B, Valli M, Rakoto JC, Jadot G, Bouyard P, Reinberg A (1979) Chronopharmacology of pancuronium in the rat: anaesthesia or seasonal influence? In: Reinberg A, Hal-Berg F (eds) Chronopharmacology. Pergamon, Oxford, pp 117

    Google Scholar 

  • Bruguerolle B, Valli M, Jadot G, Bouyard L, Bouyard P (1981) Circadian effect on carbamazepine kinetics in the rat. Eur J Drug Metab Pharmacokinet 6:189–194

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Jadot G, Valli M, Bouyard L, Bouyard P (1982) Etude chronocinétique de la lidocaïne chez le rat. J Pharmacol 13: 65–76

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Desnuelle C, Jadot G, Valli M, Acquaviva PC (1983) Chronopharmacocinétique de l’indomethacïne a effet prolonge en pathologie rhumatismale. Rev Int Rhumatisme 13: 263–267

    Google Scholar 

  • Bruguerolle B, Bouvenot G, Bartolin R (1984) Temporal and sex-related variations in lorazepam kinetics. Annu Rev Chro-nopharmacol 1: 21–24

    CAS  Google Scholar 

  • Bruguerolle B, Barbeau G, Belanger P, Labrecque G (1986a) Chronokinetics of indomethacin in elderly subjects. Annu Rev Chronopharmacol 3:425–128

    CAS  Google Scholar 

  • Bruguerolle B, Levi F, Arnaud C, Bouvenot G, Mechkouri M, Vannetzel J, Touitou Y (1986b) Alteration of physiologic circadian time structure of six plasma proteins in patients with advanced cancer. Annu Rev Chronopharmacol 3:207–210

    Google Scholar 

  • Bruguerolle B, Philip-Joet F, Parrel M, Arnaud A (1987) Unequal twice daily sustained release theophylline dosing in chronic obstructive pulmonary disease. Chronobiol Int 4: 381–385

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Bouvenot G, Bartolin R, Manolis J (1988a) Chronopharmacocinétique de la digoxine chez le sujet de plus de soixante dix ans. Therapie 43: 251–253

    PubMed  CAS  Google Scholar 

  • Bruguerolle B, Dupont M, Lebre P, Legre G (1988b) Bupiva-caine chronokinetics in man after a peridural constant rate infusion. Annu Rev Chronopharmacol 5: 223–226

    Google Scholar 

  • Bruguerolle B, Prat M, Douylliez C, Dorfman P (1988c) Are there circadian and circannual variations in acute toxicity of phenobarbital in mice? Fundam Clin Pharmacol 2: 301–304

    PubMed  CAS  Google Scholar 

  • Bruinink A, Lichtensteiger W, Schlumpf M (1983) Ontogeny of diurnal rhythms of central dopamine, serotonin and spirode-canone binding sites and of motor activity in the rat. Life Sci 33: 31–38

    PubMed  CAS  Google Scholar 

  • Cambar J, Lemoigne F, Toussaint C (1979) Diurnal variations: evidence of glomerular filtration in the rat. Experientia 35: 1607–1608

    PubMed  CAS  Google Scholar 

  • Carlebach R, Cohen-Kitay Y, Peleg L, Ashkenazi IE (1990) Chronotoxicity and genetic variability. Annu Rev Chronopharmacol 7:241–244

    Google Scholar 

  • Carosella L, Dinardo P, Bernabei R, Cocchi A, Carbonin P (1979) Chronopharmacokinetics of digitalis. Circadian variations of β-methyldigoxin serum levels after oral administration. In: Reinberg A, Halberg F (eds) Chronopharmacology. Pergamon, Oxford, p 125

    Google Scholar 

  • Ceresa F, Angeli A (1977) Chronotherapie corticoide. In: Chronothérapeutique. Expansion Scientifique Françhise (ed.), Paris, pp 211–223

    Google Scholar 

  • Clench J, Reinberg A, Dziewanowska Z, Ghata J, Smolensky M (1981) Circadian changes in the bioavailability and effects of indomethacin in healthy subjects. Eur J Clin Pharmacol 20: 359–369

    PubMed  CAS  Google Scholar 

  • Couet W, Ingrand I, Millerioux L, Lefebvre MA, Mainguy Y, Fourtillan JB (1986) Etude chronopharmacocinätique du sulindac et de ses mätabolites. Sem Hop Paris 62: 2677–2682

    CAS  Google Scholar 

  • Cuisinaud G, Guissou P, Sassard J (1984) Chronopharmaco-kinetic study of intravenous indomethacin in the rat. Annu Rev Chronopharmacol 1: 341–344

    CAS  Google Scholar 

  • Decousus H, Croze M, Levi F, Perpoint B, Jaubert J, Bonna-dona JF, Reinberg A, Queneau P (1985) Circadian changes in anticoagulant effect of heparin infused at a constant rate. Br Med J 290: 341–344

    CAS  Google Scholar 

  • Decousus H, Ollagnier M, Jaubert J, Perpoint B, Hocquart J, Queneau P (1987a) Biological rhythms and thromboembolic disease. Physiologic, epidemiologic and pharmacologic aspects. Pathol Biol 35: 985–990

    PubMed  CAS  Google Scholar 

  • Decousus H, Ollagnier M, Cherrah Y, Perpoint B, Hocquart J, Queneau P (1987b) Chronokinetics of ketoprofen infused intravenously at a constant rate. Annu Rev Chronopharmacol 3: 321–324

    Google Scholar 

  • Decousus H, Perpoint B, Boissier C, Ollagnier M, Mismetti P, Hocquart J, Queneau P (1990) Timing optimizes sustained-release ketoprofen treatment of osteoarthritis. Annu Rev Chronopharmacol 7: 289–292

    Google Scholar 

  • Descorps-Declere A, Bonnafous M, Reinberg A, Begon C (1983) Sex-related differences in diurnal and seasonal changes in effectiveness of pancuronium bromide in man. Chronobiologia 10:121–122

    Google Scholar 

  • Dettli L, Spring P (1966) Diurnal variations in the elimination rate of a sulfonamide in man. Helv Med Acta 4: 921–926

    Google Scholar 

  • Dore F, Belanger P, Labrecque G (1984) Distribution tissulaire de microsphères radioactives en fonction de l’éure du jour et de Tetat nutritionel chez le rat. Union Med Can 38: 964–966

    Google Scholar 

  • English J, Biol LI, Dunne M, Marks V (1983) Diurnal variation in prednisolone kinetics. Clin Pharmacol Ther 33: 381–385

    PubMed  CAS  Google Scholar 

  • Feuers RJ, Scheving LE (1988) Chronobiology of hepatic enzymes. Annu Rev Chronopharmacol 4: 209–254

    CAS  Google Scholar 

  • Focan C, Bruguerolle B, Arnaud C, Levi F, Mazy V, Focan-Henrard D, Bouvenot G (1988) Alteration of circadian time structure of plasma proteins in patients with inflammation. Annu Rev Chronopharmacol 5: 21–24

    Google Scholar 

  • Focan C, Doalto L, Mazy V, Levi F, Bruguerolle B, Cano JP, Rahmani R, Hecquet B (1989) Vindesine en perfusion continue de 48 heures (suivie de cisplatine) dans le cancer pul-monaire avancé. Données chronopharmacocinétiques et efficacité clinique. Bull Cancer (Paris) 76: 909–912

    CAS  Google Scholar 

  • Friedman AH, Walker CA (1972) The acute toxicity of drugs acting at cholinoceptive sites and twenty four hour rhythms in brain acetylcholine. Arch Toxicol 29:39–50

    CAS  Google Scholar 

  • Fujimura A, Kajiyama H, Kumagai Y, Nakashima H, Sugimoto K, Ebihara A (1989 a) Chronopharmacokinetic studies of propanofen and procainamide. J Clin Pharmacol 29: 786–790

    PubMed  CAS  Google Scholar 

  • Fujimura A, Ohashi K, Sugimoto K, Kumagai Y, Ebihara A (1989b) Chronopharmacokinetic study of nitrendipine in healthy subjects. J Clin Pharmacol 29: 909–915

    PubMed  CAS  Google Scholar 

  • Gautherie M, Gros CH (1977) Circadian rhythm alteration of skin temperature in breast cancer. Chronobiologia 4:1–17

    PubMed  CAS  Google Scholar 

  • Guissou P, Cuisinaud G, Llorca G, Lejeune E, Sassard J (1983) Chronopharmacokinetic study of a prolonged release form of indomethacin. Eur J Clin Pharmacol 24: 667–670

    PubMed  CAS  Google Scholar 

  • Haen E, Gerdsmeier W, Arbogast B (1985) Circadian variation in propranolol protein binding. Naunyn Schmiedebergs Arch Pharmacol 329: 393

    Google Scholar 

  • Halberg F (1969) Chronobiology. Annu Rev Physiol 3: 20–25

    Google Scholar 

  • Halberg F, Stephens A (1959) Susceptibility to ouabain and physiologic circadian periodicity. Proc Minn Acad Sci 27: 139–143

    Google Scholar 

  • Halberg F, Bettner J, Gully R (1955) Twenty four hour periodic susceptibility of audiogenic convulsions in mice. Fed Proc 14: 67–71

    Google Scholar 

  • Haus E, Halberg F (1959) 24 hours rhythm in susceptibility of C mice to toxic dose of ethanol. J Appl Physiol 14: 878–882

    PubMed  CAS  Google Scholar 

  • Hecquet B (1986) Constant pharmacologic effect and chronopharmacology: theoretical aspects. Chronobiol Int 3:149–154

    PubMed  CAS  Google Scholar 

  • Hecquet B, Sucche M (1986) Theoretical study of the influence of the circadian rhythm of plasma protein binding on cis-platin area under the curve. J Pharmacokinet Biopharm 14: 79–93

    PubMed  CAS  Google Scholar 

  • Hecquet B, Meynadier J, Bonneterre J, Adenis L (1984) Circadian rhythm in cisplatin binding on plasma proteins. Annu Rev Chronopharmacol 3:115–118

    Google Scholar 

  • Holter NJ (1961) New method for heart studies: continuous electrocardiography of active subjects over long periods is now practical. Sciences 134:1214

    CAS  Google Scholar 

  • Hrushesky W, Levi F, Kennedy BJ (1980) Cis-diaminedichloro-platinum toxicity to the human kidney reduced by circadian timing. Proc Am Soc Clin Oncol 21: 45

    Google Scholar 

  • Hrushesky W, Borch R, Levi F (1982) Circadian time dependence of cisplatin urinary kinetics. Clin Pharmacol Ther 32: 330–339

    PubMed  CAS  Google Scholar 

  • Isaacson RJ (1959) An investigation of some of the factors involved in the closure of the secondary palate. PhD Thesis, University of Minnesota, Minneapolis

    Google Scholar 

  • Jenni-Eiermann S, von Han HP, Honegger CG (1985) Circadian variations of neurotransmitter binding in three age groups of rats. Gerontology 31:138–149

    PubMed  CAS  Google Scholar 

  • Jones F, Haus E, Halberg F (1963) Murine circadian susceptibility resistance cycle to acetylcholine. Proc Minn Acad Sci 31: 61–62

    Google Scholar 

  • Jones HP (1845) On the variations of the acidity of the urine in the state of health. Philos Trans R Soc Lond 135: 335–349

    Google Scholar 

  • Jori A, di Salle E, Santini V (1971) Daily rythmic variation and liver drug metabolism in rats. Biochem Pharmacol 20: 2965–2969

    PubMed  CAS  Google Scholar 

  • Kadle R, Folk GE (1983) Importance of circadian rhythms in animal cell cultures. Comp Biochem Physiol 76: 773–776

    CAS  Google Scholar 

  • Kasal C, Perez-Polo JR (1982) Circadian rhythms in vitro. Trends Biochem Sci 7: 59–61

    CAS  Google Scholar 

  • Klotz U, Ziegler G (1982) Physiologic and temporal variation in hepatic elimination of midazolam. Clin Pharmacol Ther 32: 107–112

    PubMed  CAS  Google Scholar 

  • Labrecque G, Domino EF (1982) Temporal variations in the effect of morphine and nalorphine on total brain acetylcholine content in the rat. Arch Int Pharmacodyn Ther 259: 244–249

    PubMed  CAS  Google Scholar 

  • Labrecque G, Dore F, Belanger PM (1981) Circadian variation of carrageenan-paw edema in the rat. Life Sci 28:1337–1343

    PubMed  CAS  Google Scholar 

  • Labrecque G, Dore F, Laperriere A, Perusse F, Belanger PM (1979) Chronopharmacology. II. Variations in the carragee-nan induced edema, in the action and the plasma levels of indomethacin. In: Reinberg A, Halberg F (eds) Chronopharmacology. Pergamon, Oxford, pp 231–238

    Google Scholar 

  • Labrecque G, Belanger PM, Dore F (1982) Circannual variations in carrageenan-induced paw edema and the anti-inflammatory effect of phenylbutazone in the rat. Pharmacology 24: 169–174

    PubMed  CAS  Google Scholar 

  • Langner B, Lemmer B (1988) Circadian phase dependency in pharmacokinetics and cardiovascular effects of oral propranolol in man. Annu Rev Chronopharmacol 5: 335–338

    Google Scholar 

  • Lavigne JG, Belanger PM, Dore F, Labrecque G (1983) Temporal variations in chloroform-induced hepato-toxicity in rats. Toxicology 26: 267–273

    PubMed  CAS  Google Scholar 

  • Lecocq B, Midavaine M, Lecocq V, Jaillon P (1992) Chrono-pharmacocinetique de la nitrindipine chez le sujet sain. Ther-apie (in press)

    Google Scholar 

  • Lemmer B (1981a) Pharmacokinetics of beta-adrenoceptors blocking drugs of different polarity (propranolol, metopro-lol, atenolol) in plasma and various organs of the light-dark synchronised rat. Naunyn Schmiedebergs Arch Pharmacol 316: R 60

    Google Scholar 

  • Lemmer B (1981b) Chronopharmacokinetics. In: Breimer D, Speiser P (ed) Topics in pharmaceutical sciences. Elsevier/North-Holland, Amsterdam, p 49–68

    Google Scholar 

  • Lemmer B, Lang PH (1984) Circadian stage dependency in antagonist binding of 3H-dihydroalprenolol to rat heart ventricular membranes. Annu Rev Chronopharmacol 1: 335–338

    Google Scholar 

  • Lemmer B, Neumann G (1987) Circadian phase dependency of the effects of different β-receptor blocking drugs on motor activity of rats. Arzneimittelforschung 37: 321–325

    PubMed  CAS  Google Scholar 

  • Lemmer B, Winkler H, Ohm T, Fink M (1985) Chronopharmacokinetics of β-receptor blocking drugs of different lipophilicity (propranolol, metoprolol, sotalol, atenolol) in plasma and tissues after single and multiple dosing in rats. Naunyn Schmiedebergs Arch Pharmacol 330: 42–49

    PubMed  CAS  Google Scholar 

  • Lemmer B, Scheidel B, Stenzhorn G, Blume H, Lenhard G, Grether D, Renczes J, Becker HJ (1989) Clinical chronopharmacology of oral nitrates. Z Kardiol 78: 61–63

    PubMed  Google Scholar 

  • Lemmer B, Nold G, Behne S, Becker HJ, Liefhold J, Kaiser R (1990) Chronopharmacokinetics and hemodynamic effects of oral nifedipine in healthy subjects and in hypertensive patients. Annu Rev Chronopharmacol 7:121–124

    Google Scholar 

  • Levi F (1982) Chronopharmacologie de trois agents doués d’ac-tivité anticancéreuse chez le rat et la souris. Chronoefficacite et chronotolerance. PhD Thesis, University of Paris

    Google Scholar 

  • Levi F, Hrushesky YW, Haus E, Halberg F, Scheving LE, Kennedy BJ (1980a) Experimental chrono-oncology. NATO Adv Study Inst 3: 481–511

    Google Scholar 

  • Levi F, Lakatua D, Haus E, Hrushesky W, Halberg F, Schwartz S, Kennedy BJ (1980b) Circadian urinary N-acetylglucose-aminidase (NAG) excretion gauges murine cisdiaminedi-chloroplatinum (DDP) nephrotoxicity. Am Assoc Cancer Res 21:1232

    Google Scholar 

  • Levi F, Hrushesky W, Kennedy BJ (1981) Chronotolerance for cytostatic drugs in cancer treatment. 15th ICAR International Congress of Rheumatology, Paris

    Google Scholar 

  • Levi F, Lelouarn C, Reinberg A (1985) Timing optimizes sustained release indomethacin treatment of osteoarthritis. Clin Pharmacol Ther 37: 77–84

    PubMed  CAS  Google Scholar 

  • Levi F, Metzger G, Bailleul F, Reinberg A, Mathe G (1986) Circadian varying plasma pharmacokinetics of doxorubicin (DOX) despite continuous infusion at a constant rate. Proc Am Assoc Cancer Res 27:175

    Google Scholar 

  • Levi F, Bruguerolle B, Hecquet B (1989) Mecanismes et perspectives en chronopharmacocinetique clinique. Therapie 44: 313–321

    PubMed  CAS  Google Scholar 

  • Lockard JS, Levy RH, Ducharme LL, Congdom WC, Patel IH (1979) Carbamazepine revisited in a monkey model. Epilepsia 20:169–173

    PubMed  CAS  Google Scholar 

  • Lockard JS, Viswanathan CT, Levy RH (1985) Diurnal oscillations of CSF valproate in monkey. Life Sci 36:1281–1285

    PubMed  CAS  Google Scholar 

  • Margules DL, Lewis MJ, Dragovitch JA, Margues A (1972) Hypothalamic norepinephrine: circadian rhythms and the control of feeding behavior. Science 178: 640–647

    PubMed  CAS  Google Scholar 

  • Markiewicz A, Semenowicz K (1979) Time dependent change in the pharmacokinetics of aspirin. Int J Clin Pharmacol Bio-pharm 17: 409–411

    CAS  Google Scholar 

  • Markiewicz A, Semenowicz K (1980) Does a rhythmicity of serum concentrations and urinary excretion of dipyridamole exist during long term treatment? Pol J Pharmacol Pharm 32: 289–295

    PubMed  CAS  Google Scholar 

  • Marte E, Halberg F (1961) Circadian susceptibility rhythm of mice to librium. Fed Proc 20: 305

    Google Scholar 

  • Marte E, Nelson DO, Matthews JH, Halberg F (1978) Circadian rhythm in murine susceptibility to anesthetics halothane and methohexital. Int J Chronobiol 5:425–426

    Google Scholar 

  • Mato M, Ookawara S, Tooyama K, Ishizaki T (1981) Chrono-biological studies on the blood brain barrier. Experientia 37: 1013–1015

    PubMed  CAS  Google Scholar 

  • Maxeykyle G, Smolensky MH, McGovern JP (1979) Circadian variation in the susceptibility of rodents to the toxic effects of theophylline. In: Reinberg A, Halberg F (eds) Chronobiol-ogy. Pergamon, Oxford, p 239

    Google Scholar 

  • Munson ES, Marucci RW, Smith RE (1970) Circadian variations in anaesthetic requirement and toxicity in rats. Anesthesiology 32: 507–514

    PubMed  CAS  Google Scholar 

  • Naber D, Wirz-Justice A, Kafka MS, Wehr TA (1980) Dopamine receptor binding in rat striatum: ultradian rhythm and its modification by chronic imipramine. Psychopharma-cology 68:1–5

    CAS  Google Scholar 

  • Naber D, Wirz-Justice A, Kafka MS (1981a) Circadian rhythm in rat brain opiate receptor. Neurosci Lett 21: 45–50

    PubMed  CAS  Google Scholar 

  • Naber D, Wirz-Justice A, Kafka MS, Tobler I, Borbely A (1981b) Seasonal variation in the endogenous rhythm of dopamine receptor binding in rat striatum. Biol Psychiatry 16: 831–835

    PubMed  CAS  Google Scholar 

  • Nagayama H, Takagi A, Sakurai I, Nishiwaki K, Takahasi RT (1978) Chronopharmacological study of neuroleptics. Psy-chopharmacology 58: 49–53

    CAS  Google Scholar 

  • Nair V (1974) Circadian rhythm in drug action: a pharmacologic, biochemical and electron-microscopic study: In: Scheving LE, et al. (eds) Chronobiology. Igaku-Shoin, Tokyo, p 182

    Google Scholar 

  • Nair V, Casper R (1969) The influence of light on daily rhythm in hepatic drug metabolising enzymes in rat. Life Sci 8:1291–1298

    PubMed  CAS  Google Scholar 

  • Nakano S, Hollister LE (1978) No circadian effect on nortriptyline kinetics in man. Clin Pharmacol Ther 23:199–203

    PubMed  CAS  Google Scholar 

  • Nakano S, Watanabe H, Nagai K, Ogawa N (1984) Circadian stage dependent changes in diazepam kinetics. Clin Pharmacol Ther 36: 271–277

    PubMed  CAS  Google Scholar 

  • Naranjo CA, Sellers SEM, Giles HG, Abel JG (1980) Diurnal variations in plasma diazepam concentrations associated with reciprocal changes in free fraction. Br J Clin Pharmacol 9: 265–272

    PubMed  CAS  Google Scholar 

  • Nelson W, Halberg F (1973) An evaluation of time-dependent changes in susceptibility of mice to pentobarbital injection. Neuropharmacology 12:509–524

    PubMed  CAS  Google Scholar 

  • Nelson W, Tong YL, Lee YK, Halberg F (1979) Methods for Cosinor-rhythmometry. Chronobiologia 6: 305–323

    PubMed  CAS  Google Scholar 

  • Njus D, Sulzman FM, Hastings TW (1974) Membrane model for the circadian clock. Nature 248:116–120

    PubMed  CAS  Google Scholar 

  • Patel IH, Venkataramanan R, Levy RH, Viswanathan CT, Ojemann LM (1982) Diurnal oscillations in plasma protein binding of valproic acid. Epilepsia 23: 282–290

    Google Scholar 

  • Pariat C, Cambar J, Courtois P (1984) Circadian variations in the acute toxicity of three aminoglycoside: gentamicin dibe-kacin and netilmicin in mice. Annu Rev Chronopharmacol 1: 381–384

    CAS  Google Scholar 

  • Petit E, Milano G, Levi F, Thyss A, Bailleul F, Schneider M (1988) Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five day continuous venous infusion at a constant rate in cancer patients. Cancer Res 48: 1676–1679

    PubMed  CAS  Google Scholar 

  • Pollmann L (1981) Circadian changes in the duration of local anesthesia. J Interdiscip Cycle Res 12:187–192

    Google Scholar 

  • Prat M, Bruguerolle B (1988) Chronotoxicity and chronokinetics of two local anaesthetic agents, bupivacaine and mepivacaine, in mice. Annu Rev Chronopharmacol 5: 263–266

    CAS  Google Scholar 

  • Queneau P, Ollagnier M, Decousus H, Cherrah Y (1984) Ketoprofen chronokinetics in human volunteers. Annu Rev Chronopharmacol 1: 353–356

    CAS  Google Scholar 

  • Radzialowski FM, Bousquet WF (1968) Daily rhythmic variation in hepatic drug metabolism in the rat and mouse. J Pharmacol Exp Ther 163: 229–238

    PubMed  CAS  Google Scholar 

  • Reinberg A (1974) Chronopharmacology in man. Chronobiologia 1:157–185

    PubMed  Google Scholar 

  • Reinberg A (1976) Advances in human chronopharmacology. Chronobiologia 3:151–166

    PubMed  CAS  Google Scholar 

  • Reinberg A (1978) Clinical chronopharmacology, an experimental basis for chronotherapy. Arzneimittelforschung 28:1861–1867

    PubMed  CAS  Google Scholar 

  • Reinberg A (1979) Des rythmes biologiques à la chronobiol-ogie, 3rd edn. Gauthier-Villars, Paris

    Google Scholar 

  • Reinberg A (1982) La chronopharmacologie. Recherche 13: 478–489

    CAS  Google Scholar 

  • Reinberg A, Ghata J (1990) Les rythmes biologiques, 5th edn. Presses Universitaires de France, Paris

    Google Scholar 

  • Reinberg A, Halberg F (1971) Circadian chronopharmacology. Annu Rev Pharmacol 11: 455–492

    PubMed  CAS  Google Scholar 

  • Reinberg A, Reinberg MA (1977) Circadian changes of duration of action of local anaesthetic agents. Naunyn Schmiede-bergs Arch Pharmacol 297:149–152

    CAS  Google Scholar 

  • Reinberg A, Smolensky MH (1982) Circadian changes of drug disposition in man. Clin Pharmacokinet 7: 401–420

    PubMed  CAS  Google Scholar 

  • Reinberg A, Ghata J, Halberg F, Apfelbaum M, Gervais P, Bourdon P, Aboulker C, Dupont J (1971) Distribution tem-porelle du traitement de l’insuffisance corticosurrénalienne. Essai de chronothérapeutique. Ann Endocrinol (Paris) 32: 566–573

    Google Scholar 

  • Reinberg A, Clench J, Ghata J, Halberg F, Abulker C, Dupont J, Zagula-Mally Z (1975) Rythmes circadiens des parametres de l’excrétion urinaire du salicylate (chronopharmacocinetique) chez l’homme adulte sain. C R Acad Sci [D] (Paris) 280:1697–1700

    CAS  Google Scholar 

  • Reinberg A, Schuller E, Deslanerie N, Clench J, Helary M (1977) Rythmes circadiens et circannuels des leucocytes, pro-teines totales, immunoglobulines A, G et M. Etude chez neuf adultes jeunes et sains. Nouv Presse Med 6:3819–3823

    PubMed  CAS  Google Scholar 

  • Reinberg A, Gervais P, Chaussade M, Fraboulet G, Duburque B (1983) Circadian changes in effectiveness of corticosteroids in eight patients with allergic asthma. Chronobiologia 1: 333–347

    Google Scholar 

  • Reinberg A, Levi F, Touitou Y, Le Liboux A, Simon J, Frydman A, Bicakova-Rocher A, Bruguerolle B (1986) Clinical chronokinetic changes in a sustained release preparation of ketoprofen. Annu Rev Chronopharmacol 3: 317–320

    CAS  Google Scholar 

  • Reinberg A, Levi F, Smolensky M, Labrecque G, Ollagnier M, Decousus H, Bruguerolle B (1990) Chronokinetics. In: Hansch C (ed) Comprehensive medicinal chemistry, vol 5. Pergamon, Oxford, pp 279–296

    Google Scholar 

  • Riva R, Albani F, Ambrosetto G, Contin M, Cortelli P, Perucca E, Baruzzi A (1984) Diurnal fluctuations in free and total steady state plasma levels of carbamazepine and correlation with intermittent side effects. Epilepsia 25: 476–481

    PubMed  CAS  Google Scholar 

  • Ross FH, Graig NL, Sermons Al, Walker CA (1981) Chronotoxicity of antidepressant and psychomotor stimulants in mice. In: Halberg F et al. (Eds.) 13th International Conference of the International Society of Chronobiology, p 125

    Google Scholar 

  • Sauerbier R (1979) Circadian aspects of the teratogenicity of cytostatic drugs. Chronobiologia 6:152

    Google Scholar 

  • Sauerbier I (1980) Recent findings relative to teratology and chronobiology. NATO Adv Study Inst 3: 535

    Google Scholar 

  • Scheving LE (1980) Chronotoxicology in general and experimental chronotherapeutics of cancer. NATO Adv Study Inst 3: 455

    Google Scholar 

  • Scheving LE, Pauly JE (1976) Chronopharmacology; its implication for clinical medicine. Annu Rep Med Chem 11: 251–260

    CAS  Google Scholar 

  • Scheving LE; Vedral D (1966) Circadian variation in susceptibility of the rat to several different pharmacological agents. Anat Rec 154: 417–422

    Google Scholar 

  • Scheving LE, von Mayersbach H, Pauly JE (1974) An overiew of chronopharmacology. J Eur Toxicol 7: 203–227

    CAS  Google Scholar 

  • Schulz B, Greenfield M, Reaven GM (1983) Diurnal variation in specific insulin binding to erythrocytes. Exp Clin Endocrinol 81:273–279

    PubMed  CAS  Google Scholar 

  • Scott B, Gulline H (1975) Membrane changes in a circadian system. Nature 254: 69–70

    PubMed  CAS  Google Scholar 

  • Sermons AL, Ross FH, Walker CA (1980) 24 hours toxicity rhythms of sedative hypnotic drugs in mice. Arch Toxicol 45: 9–14

    PubMed  CAS  Google Scholar 

  • Shively CA, Vesell ES (1975) Temporal variations in acetaminophen and phenacetin half-life in man. Clin Pharmacol Ther 18: 413–424

    PubMed  CAS  Google Scholar 

  • Shively CA, Simons RJ, Passananti GT, Dvorchik BH, Vesell ES (1981) Dietary patterns and diurnal variations in aminopyrine disposition. Clin Pharmacol Ther 29: 65–73

    PubMed  CAS  Google Scholar 

  • Smith RB, Kroboth PD, Phillips JP (1986) Temporal variation in triazolam pharmacokinetics and pharmacodynamics after oral administration. J Clin Pharmacol 26: 120–124

    PubMed  CAS  Google Scholar 

  • Smolensky MH (1989) Chronopharmacology of theophylline and β-sympathomimetics. In: Lemmer B (ed) Chronopharmacology cellular and biochemical interactions. Dekker, New York, pp 65–114

    Google Scholar 

  • Spoor RP, Jackson DB (1966) Circadian rhythms: variation in sensitivity of isolated rat atria to acetylcholine. Science 154: 782–789

    PubMed  CAS  Google Scholar 

  • Touitou Y (1982) Some aspects of the circadian time structure in the elderly. Gerontology 28: 53–67

    PubMed  CAS  Google Scholar 

  • Touitou Y (1987) Le vieillissement des rythmes biologiques chez l’homme. Pathol Biol 35:1005–1012

    PubMed  CAS  Google Scholar 

  • Touitou Y, Touitou C, Bogdan A, Reinberg A, Auzeby A, Beck H, Guillet PH (1986) Differences between young and elderly subjects in seasonal and circadian variations of total plasma proteins and blood volume as reflected by hemoglobin, hematocrit and erythrocyte counts. Clin Chem 32: 801–804

    PubMed  CAS  Google Scholar 

  • Ungar F, Reinberg A (1962) Circadian rhythm in the in vitro response of mouse adrenal to adrenocorticotropic. Science 137: 1058–1060

    PubMed  CAS  Google Scholar 

  • Vesell ES, Shively CA, Passananti GT (1977) Temporal variations of antipyrine half-life in man. Clin Pharmacol Ther 22: 843–852

    PubMed  CAS  Google Scholar 

  • Wirz-Justice A (1987) Circadian rhythms in mammalian neurotransmitter receptors. Prog Neurobiol 29:219–259

    PubMed  CAS  Google Scholar 

  • Wirz-Justice A, Kafka MS, Naber D, Wehr TA (1980) Circadian rhythms in rat brain α and β-adrenergic receptors are modified by chronic imipramine. Life Sci 27: 341–347

    PubMed  CAS  Google Scholar 

  • Wirz-Justice A, Tobler I, Kafka MS, Naber D, Marangos PJ, Borbely A, Wehr TA (1981) Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors. Psy-chiat Res 5: 67–76

    CAS  Google Scholar 

  • Wirz-Justice A, Krauchi K, Morima SAT, Willener R, Feer H (1983) Circadian rhythm of 3H-Imipramine binding in the rat suprachiasmatic nuclei. Eur J Pharmacol 87: 331–333

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. Bruguerolle
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bruguerolle, B. (1992). Chronopharmacology. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78734-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78736-2

  • Online ISBN: 978-3-642-78734-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation