Chronobiological observations lead to the hypothesis that the response of an organism to a drug may depend on the hour of administration. Virey was one of the first who suggested in 1814 that desired and un-desired effects of a drug may vary according to the time of its administration (Reinberg 1979). Later this hypothesis was validated and the toxicity and efficiency of many drugs have been shown to depend on their time of administration. Some of the mechanisms involved in the time-dependent (chronopharmaco-logical) responses are documented at the present time.


Circadian Rhythm Peak Expiratory Flow Hepatic Blood Flow Dark Phase Circadian Variation 
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© Springer-Verlag Berlin Heidelberg 1992

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  • B. Bruguerolle

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