Advertisement

Chronobiology of Endocrine and Endocrine-Responsive Tumors

  • R. von Roemeling

Abstract

A prominent feature of the endocrine system is its high degree of temporal organization, which was recently reviewed by van Cauter [1]. Far from obeying the concept of constancy of the internal environment, circulating hormone levels spontaneously undergo pronounced oscillations. Plasma levels of adrenocorti-cotropin (ACTH), growth hormone (GH) and prolactin (PRL) follow a circadian pattern which repeats itself day after day. PRL levels decrease rapidly after morning awakening, a time when ACTH release is close to its maximum and GH secretion is generally quiescent. Both PRL and GH increase rapidly after sleep onset, a time when ACTH levels are essentially suppressed. Under normal conditions, the 24-h profile of plasma PRL levels follows a bimodal pattern, with minimal concentrations around noon, and afternoon phase of augmented secretion and a major nocturnal elevation starting shortly after sleep onset and culmi-nating around mid-sleep. Thus, the release of these three hormones by the pituitary follows a highly coordinated temporal program. Pulsatile secretion is evident throughout the 24-h cycle for ACTH and PRL (Fig. 1). In contrast, pulses of GH secretion occur less frequently and are often confined to the early part of sleep. In addition to the circadian and pulsatile variations, other ultradian and infradian rhythms also occur. The ultradian range includes a pulsatile release of pituitary and pituitary-dependent hormones and ultrafast fluctuations with periods of reoccurrence in the range of minutes.

Keywords

Breast Cancer Circadian Rhythm Natural Killer Activity Thymidine Kinase Activity Circannual Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    van Cauter E (1989) Endocrine rhythms. In: Arendt J, Minors DS, Waterhouse JM (eds) Biological rhythms in clinical practice. Wright, London, pp 23–50Google Scholar
  2. 2.
    Arendt J, Broadway J (1987) Light and melatonin as zeit-gebers in man. Chronobiol Int 4: 273–282PubMedCrossRefGoogle Scholar
  3. 3.
    English J, Arendt J, Symons AM, Poulton AL, Tobler I (1988) Pineal and ovarian response to 22- and 14-h days in the ewe. Biol Reprod 39: 9–18PubMedCrossRefGoogle Scholar
  4. 4.
    English J, Aherne GW, Arendt J (1988) Modulation of the circadian rhythm in methotrexate toxicity in the rat by melatonin and photoperiod. In: Reinberg A, Smolensky M, Labrecque G (eds) Annual review of chronopharmacology, vol 5. Pergamon, Oxford, p 359Google Scholar
  5. 5.
    Loros JJ, Denome SA, Dunlap JC (1989) Molecular cloning of genes under control of the circadian clock in Neurospora. Science 243: 385–388PubMedCrossRefGoogle Scholar
  6. 6.
    Henderson BE, Ross RK, Pike MC, Casagrande JT (1982) Endogenous hormones as a major factor in human cancer. Cancer Res 42: 3232–3239PubMedGoogle Scholar
  7. 7.
    Huggins C (1967) Endocrine-induced regression of cancers. Science 156:1050–1054PubMedCrossRefGoogle Scholar
  8. 8.
    Crile G (1966) Endocrine dependency of papillary carcinomas of the thyroid. J Am Med Assoc 195: 721–724CrossRefGoogle Scholar
  9. 9.
    Sommers SC, Meissner WA (1957) Endocrine abnormalities accompanying human endometrial cancer. Cancer 10: 516–521PubMedCrossRefGoogle Scholar
  10. 10.
    McMahon B, Cole P, Brown J (1973) Etiology of human breast cancer: a review. J Natl Cancer Inst 50: 21–42Google Scholar
  11. 11.
    Tarquini B, Halberg F, Seal US, Benvenuti M, Cagnoni M (1981) Circadian aspects of serum prolactin and TSH lowering by bromocriptine in patients with prostatic hypertrophy. Prostate 2: 269–279PubMedCrossRefGoogle Scholar
  12. 12.
    Crawford ED, Blumenstein BA, Goodman PJ, Davis MA, Eisenberger MA, McLeod DG, Spaulding JT, Benson R, Dorr FA (1990) Leuprolide with and without flutamide in advanced prostate cancer. Cancer 66 (Suppl 5): 1039–1044PubMedGoogle Scholar
  13. 13.
    Joly DJ, Lilienfeld AM, Diamond EL, Bross IDJ (1974) An epidemiologic study of the relationship of reproductive experience to cancer of the ovary. Am J Epidemiol 99:190–209PubMedGoogle Scholar
  14. 14.
    van Vliet G, Canfriez A, Robyn C, Wolter R (1980) Plasma gonadotropin values in prepubertal cryptorchid boys: similar increase of FSH secretion in uni- and bilateral cases. J Pediatr 39: 253–255Google Scholar
  15. 15.
    Barbason H, Smoliar V, van Cantfort J (1979) Correlation of liver growth and function during liver regeneration and hepatocarcinogenesis. Arch Toxicol Suppl 2:157–169PubMedCrossRefGoogle Scholar
  16. 16.
    Barbason H, Rassenfosse C, Betz EH (1983) Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogeneses cell kinetcs effect. Br J Cancer 47: 517–525PubMedCrossRefGoogle Scholar
  17. 17.
    Mormont MC, Rabatin J, Lakatua D, Sothern R, Roemel-ing R, Hrushesky WJM (1987) Phenobarbital tumor promotion is related to an alteration of the circadian corticosterone rhythm. Proc Am Assoc Cancer Res 28:170Google Scholar
  18. 18.
    Hrushesky WJM, Sothern RB, Lévi FA, Olshefsky R, Lan-nin D, Berestka JS, Gruber SA (1989) Circadian timing, anatomic location and dose of tumor cell inoculum each affect tumor biology. Proc Am Assoc Cancer Res 30: 82Google Scholar
  19. 19.
    Gatti G, Cavallo R, Del Ponte D, Sartori M, Masera R, Ca-rignola R, Carandente F, Angeli A (1986) Circadian changes of human natural killer (NK) cells and their in vitro susceptibility to Cortisol inhibition. In: Reinberg A, Smolensky M, Labrecque G (eds) Annual review of chronopharmacology, vol 3. Pergamon, Oxford, pp 75–78Google Scholar
  20. 20.
    Gatti G, Sartori ML, Cavallo R, Del Ponte D, Carignola R, Salvadori A, Masera R, Angeli A (1987) Circadian variation of human natural killer (NK) cell response to positive modulation by immune interferon and negative modulation by Cortisol. Chronobiologia 14:178Google Scholar
  21. 21.
    Levi FA, Canon C, Touitou Y, Reinberg A, Mathe G (1988) Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects. J Clin Invest 81: 407–413PubMedCrossRefGoogle Scholar
  22. 22.
    Hrushesky WJM, Gruber SA, Sothern RB, Hoffman RA, Lakatua D, Carlson A, Cerra F, Simmons RL (1988) Natural killer cell activity: age, estrous- and circadian-stage dependence and inverse correlation with metastatic potential. J Natl Cancer Inst 80:1232–1237PubMedCrossRefGoogle Scholar
  23. 23.
    Hrushesky WJM, Haus E, Lakatua D, Vogelzang N, Kennedy BJ (1983) Seasonality in testicular cell proliferation and seminoma incidence. Proc Am Soc Clin Oncol 24:18Google Scholar
  24. 24.
    Boon ME, Rietveld PEM, Rietveld WJ, Sothern RB, Hrushesky WJM (1987) Seasonal rhythmicity in incidence of cervical neoplasia and infections in Dutch women. Chronobiologia 14:154Google Scholar
  25. 25.
    Klevecz RR, Braly PS (1986) Synchronous waves of proliferation in human ovarian cancers. In: Reinberg A, Smolensky M, Labrecque G (eds) Annual review of chronopharmacology, vol 5. Pergamon, Oxford, pp 175–178Google Scholar
  26. 26.
    Klevecz RR, Shymko RM, Blumenfeld D, Braly PS (1987) Circadian gating of S phase in human ovarian cancer. Cancer Res 47: 6267–6271PubMedGoogle Scholar
  27. 27.
    Braly PS, Klevecz RR (1987) Cell kinetic measurements in “in vivo” human cancers - the effect of surgical debulking. Chronobiologia 14:154Google Scholar
  28. 28.
    Touitou Y, Lévi F, Ferment O, Bailleul F, Bogdan A, Auzeby A, Chevelle C, Lesaunier F (1987) CA 125 rhythmicity in ovarian cancer patients. The effect of chemotherapy. Chronobiologia 14: 250Google Scholar
  29. 29.
    Touitou Y, Bailleul F, Lévi F, Bogdan A, Touitou C, Metzger G, Mechkouri M (1990) Circadian rhythms of tumor markers in breast cancer patients. In: Hayes DK, Pauly JE, Reiter RJ (eds) Chronobiology: its role in clinical medicine, general biology, and agriculture, part A. Wiley-Liss, New York, pp 59–66Google Scholar
  30. 30.
    Hallek M, Emmerich B (1990) Biological rhythms of tumor markers in cancer patients. Cancer Res Clin Oncol 116 (Suppl 1): 1073Google Scholar
  31. 31.
    Levi F, Halberg F, Haus E, Sanchez de la Pena S, Sothern RB, Halberg E, Hrushesky W, Brown H, Scheving LE, Kennedy BJ (1980) Synthetic adrenocorticotropin for optimizing murine circadian chronotolerance for Adriamycin. Chronobiologia 7: 227–244PubMedGoogle Scholar
  32. 32.
    Kodama M, Kodama T (1982) Influence of corticosteroid hormones on the therapeutic efficacy of cyclophosphamide. Gann 73: 661–666PubMedGoogle Scholar
  33. 33.
    Halberg F, Sanchez S, Brown H, Haus E, Melby J, Wilson T, Sothern R, Berg H, Scheving LE (1980) Pretreatment with time-dependent active short-chain adrenocorticotropin (ACTH-17); HOE 433) for convenient optimization of murine Adiamycin chronotolerance. Am Assoc Cancer Res 21: 307Google Scholar
  34. 34.
    Hrushesky WJM (1985) Circadian timing of cancer chemotherapy. Science 228:73–75PubMedCrossRefGoogle Scholar
  35. 35.
    Hrushesky WJM (1987) Circadian scheduling of chemotherapy increases ovarian patient survival and cancer responses significantly. Proc Am Soc Clin Oncol 6:120Google Scholar
  36. 36.
    Lévi F, Benavides M, Chevelle C, Le Saunier F, Bailleul F, Misset JL, Regensberg C, Vannetzel JM, Reinberg A, Mathé G (1990) Chemotherapy of advanced ovarian cancer with 4’-0-tetrahydropyranyl doxorubicin and cisplatin: a randomized phase II trial with an evaluation of circadian timing and dose-intensity. J Clin Oncol 8: 705–714PubMedGoogle Scholar
  37. 37.
    Mühlbock O (1958) The hormonal genesis of mammary cancer. J Endocrinol 17: vii-xvPubMedCrossRefGoogle Scholar
  38. 38.
    Haus E, Halberg F (1962) Adrenocortical changes after supplementary heterotopic pituitary isografting in ovariec-tomized C-mice. Endocrinology 70: 837–841PubMedCrossRefGoogle Scholar
  39. 39.
    Tamarkin L, Almeida OFX, Danforth DN Jr (1985) Melatonin and malignant disease. In: Ciba Foundation Symposium 117: Photoperiodism, melatonin, and the pineal. Pitman, London, pp 284–299Google Scholar
  40. 40.
    Wrba H, Halberg F, Dutter A (1986) Melatonin circadian stage-dependently delays breast tumor development in mice injected daily for several months. Chronobiologia 13: 123–128PubMedGoogle Scholar
  41. 41.
    Wrba H, Dutter A, Sanchez de la Peña S, Wu J, Carandente F, Cornélissen G, Halberg F (1989) Secular or circannual effects of placebo and melatonin on murine breast cancer. In: Hayes DK, Pauly JE, Reiter RJ (eds) Chronobiology: its role in clinical medicine, general biology, and agriculture, part A. Wiley-Liss, New York, pp 31–40Google Scholar
  42. 42.
    Manni A (1989) Endocrine therapy of breast and prostate cancer. Endocrinology and metabolism. Clin N Am 18:569–592Google Scholar
  43. 43.
    Scheving LE, Pauly JE, Tsai TH, Scheving LA (1986) Rhythms in enzymes of brain and liver; cell proliferation in various tissues and the effect of epidermal growth factor (EGF), insulin and glucagon on these rhythms. In: Rietveld WJ (ed) Clinical aspects of chronobiology. Cip-Gegevens, Den Haag, pp 105–126Google Scholar
  44. 44.
    Labrosse K, Haus E, Lakatua DJ, Halberg F (1978) Orcadian rhythm in mammary cytoplasmic estrogen receptor content in mice with and without pituitary isografts and demonstrated differences in breast cancer risk. Proc Endocrine Soc, 60th annu meeting, p 407Google Scholar
  45. 45.
    Kiang DT, King M, Zhang HJ, Kennedy BJ (1982) Cyclic biological expression in mouse mammary tumors. Science 216: 68–70PubMedCrossRefGoogle Scholar
  46. 46.
    Ratajczak HV, Sothern RB, Hrushesky WJM (1988) Estrous influence on surgical cure of a mouse breast cancer. J Exp Med 168:73–83PubMedCrossRefGoogle Scholar
  47. 47.
    Hrushesky WJM, Bluming AZ, Gruber SA, Sothern RB (1989) Menstrual influence on surgical cure for breast cancer. The Lancet II: 949–952CrossRefGoogle Scholar
  48. 48.
    Jacobson HI, Janerich DT (1977) Seasonal variation in the diagnosis of breast cancer. Proc Am Assoc Cancer Res 18:93Google Scholar
  49. 49.
    Cohen P, Wax Y, Modan B (1983) Seasonality in the occurrence of breast cancer. Cancer Res 43: 892–896PubMedGoogle Scholar
  50. 50.
    Langlands AO, Simpson H, Sothern RB, Halberg F (1977) Different timing of circannual rhythm in mortality of women with breast cancer diagnosed before and after menopause. Proceedings of the 8th international scientific meeting of the International Epidemiological Association. San Juan, Puerto Rico, 9/17–23,1977Google Scholar
  51. 51.
    Halberg F, Cornélissen G, Sothern RB, Wallach LA, Halberg E, Ahlgren A, Kuzel M, Radke A, Barbosa J, Goetz F, Buckley J, Mandel J, Schuman L, Haus E, Lakatua D, Sackett L, Berg H, Wendt HW, Kawasaki T, Ueno M, Uezono K, Matsuoka M, Omae T, Tarquini B, Cagnoni M, Sainz MG, Vega EP, Wilson D, Griffith K, Donati L, Tatti P, Vasta M, Locatelli J, Camagna A, Lauro R, Tritsch G, Wet-terberg L (1981) International geographic studies of oncological interest on chronobiological variables chap 37. In: Kieser H (ed) Neoplasms - comparative pathology of growth in animals, plants, and man. Williams and Wilkins, Baltimore, pp 553–596Google Scholar
  52. 52.
    Tarquini B, Gheri R, Romano S, Costa A, Cagnoni M, Lee JK, Halberg F (1979) Circadian mesor-hyperprolactinemia in fibrocystic mastopathy. Am J Med 66: 229–237PubMedCrossRefGoogle Scholar
  53. 53.
    Singh RK, Singh S, Razdan JL (1987) Circadian periodicity of plasma 17-hydroxycorticosteroids in advanced breast cancer. In: Pauly JE, Scheving LE (eds) Advances in chronobiology, part B. Progress in clinical and biological research, vol 227 B. Liss, New York pp 335–342Google Scholar
  54. 54.
    Hughes A, Jacobson HI, Wagner RK, Jungblut PW (1976) Ovarian independent fluctuations of estradiol receptor levels in mammalian tissues. Mol Cell Endocrinol 5: 379–398PubMedCrossRefGoogle Scholar
  55. 55.
    Jacobson HI, Janerich DT (1980) Is seasonality in human reproduction related to seasonality in tissue levels of estrogen receptor? In: Mahesh VB, Muldoon TG, Saxena BB, Sadler WA (eds) Functional correlates of hormone receptors in reproduction. Elsevier North Holland, New York, pp 573–578Google Scholar
  56. 56.
    Hrushesky WJM, Teslow I, Halberg F, Kiang D, Kennedy BJ (1979) Temporal components of predictable variability along the 1-year scale in estrogen receptor concentration of primary human breast cancer. Proc, Am Soc Clin Oncol 20: 331Google Scholar
  57. 57.
    Smolensky MH (1983) Aspects of human chronopathology. In: Reinberg A, Smolensky MH (eds) Biological rhythms and medicine. Cellular, metabolic, physiopathologic, and pharmacologic aspects. Springer, Berlin Heidelberg New York, pp 131–209Google Scholar
  58. 58.
    Simpson HW, Pauson A, Cornélissen G (1989) The chronopathology of breast cancer. Chronobiologia 16: 365–372PubMedGoogle Scholar
  59. 59.
    Simpson HW, Griffith K (1989) The diagnosis of breast precancer by the chronobra. I. Background review. II. The breast pre-cancer test. Chronobiol Int 6: 355–393PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • R. von Roemeling

There are no affiliations available

Personalised recommendations