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Abstract

Arterial and venous thromboembolic disorders remain the leading cause of death in most of the develop countries. A thrombotic occlusion of a coronary or cerebral artery, already damaged by atherosclerosis, appears to be a common and essential link in the onset of most of the cases of such vascular events and induces myocardial or cerebral infarctions [1, 2]. It is not surprising, therefore, that these vascular disorders and the hemostatic system are correlated. For example, high levels of plasma fibrinogen and factor VII coagulant activity were associated with an increased risk of death from cardiovascular disease [3]. High plasma levels of the fast-acting plasminogen activator inhibitor (PAI-1) seem also to be correlated with acute coronary thrombosis [4]. In venous thrombosis the relationship between the disease and the hemostatic system is even more patent. Thus, biological rhythms which modulate the hemostatic system are expected to relate to temporal changes in the incidence of thromboembolic disorders. Such rhythms may also induce temporal variations in the biological effect of antithrombotic agents. Possible therapeutic implications of these observations for the treatment of thromboembolic disorders deserve to be considered and evaluated.

Keywords

Circadian Rhythm Deep Vein Thrombosis Sudden Cardiac Death Circadian Variation Morning Peak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1992

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  • H. Decousus

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