Abstract
Several recent chronoimmunological studies have demonstrated many prominent rhythms in the functional activities of lymphoid cells in both animals and humans (Ford 1975; Fernandes et al. 1976, 1984; Haus et al. 1983; Levi et al. 1985; Caradente et al. 1988b). Indeed, peripheral blood leukocyte (PBL) counts and cells from several other lymphoid tissues undergo large amplitude circadian-dependent changes (Halberg and Visscher 1950; Brown and Dougherty 1956; Fauci 1975; Scheving et al. 1978). The acrophase of the PBL count usually occurs 8–12 h apart from the acrophase of serum corticos- terone (Fernandes et al. 1981; Kreiger and Aschoff 1974). This may indicate that endocrine hormonal activity may regulate circadian-dependent movement of lymphoid cells from various lymphoid tissues to peripheral blood. However, in the diseased state, both the acrophase and/or amplitude of many biological rhythms vary considerably (Halberg et al. 1973; McGovern et al. 1976). Descriptions of circadian-dependent changes in cellular and humoral immune responses suggest that both cell loss and changes in cellular antigen density may be under the influence of several endocrine hormones and/or lym-phokines. Altered production and synthesis of many biological factors and changes in membrane proteins or their receptor concentrations may significantly modify the immune response during circadian stages and particularly during stress or disease.
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Fernandes, G. (1992). Chronobiology of Immune Functions: Cellular and Humoral Aspects. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_36
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DOI: https://doi.org/10.1007/978-3-642-78734-8_36
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