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Chronobiology of the Gastrointestinal System

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Biologic Rhythms in Clinical and Laboratory Medicine

Abstract

Rhythmicity characterizes many functions of the human organism, including those of the gastrointestinal (GI) system. Important and significant time-dependent changes have been documented in GI motility patterns [1, 2], drug intestinal absorption rates [3, 4], small bowel mucosal enzyme activities [5], mucosal DNA synthesis rates [6], and gastric acid secretion [7], among others [8]. The literature on chronobiologically oriented investigations in humans and animals, at both the organ and cellular level, is vast and beyond the scope of this discussion. This review will focus only on large amplitude rhythms of human GI motor, absorptive, and secretory function with real or potential influence on disease expression and/or treatment. Circadian rhythms will be emphasized although important ultradian rhythms of GI function will also be mentioned.

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References

  1. Kumar D, Wingate D, Ruckebush Y (1986) Circadian variation in the propagating velocity of the migrating motor complex. Gastroenterology 91: 926–930

    PubMed  CAS  Google Scholar 

  2. Goo RH, Moore JG, Greenberg E, Alazraki NP (1987) Circadian variation in gastric emptying of meals in man. Gastroenterology 93:515–518

    PubMed  CAS  Google Scholar 

  3. Clench J, Reinberg A, Dziewanowski Z, Ghata J, Smolensky MH (1981) Circadian changes in the bioavailability and effects of indomethacin in healthy subjects. Eur J Clin Pharmacol 20: 359–369

    Article  PubMed  CAS  Google Scholar 

  4. Reinberg A, Smolensky MH (1982) Circadian changes of drug disposition in man. Clin Pharmacokin 7: 401–420

    Article  CAS  Google Scholar 

  5. Markiewicz A, Karminski M, Tarquini B, Halberg F (1981) Circadian rhythm of enzymatic activity in human jejunum. Int J Chronobiol 7: 282

    Google Scholar 

  6. Buchi KN, Rubin NH, Moore JG (1988) Circadian cellular proliferation in human rectal mucosa. Annu Rev Chrono-pharm 5: 355

    Google Scholar 

  7. Moore JG, Englert E (1970) Circadian rhythm of gastric acid secretion in man. Nature 226:1261–1262

    Article  PubMed  CAS  Google Scholar 

  8. Vener K, Moore JG (1988) Chronobiologic properties of the alimentary canal affecting xenobiotic absorption. Annu Rev Chronopharm 4: 257–281

    CAS  Google Scholar 

  9. Telander RL, Morgan KG, Krevlen DL, Schmalz PF, Kelly K, Szurszewski JH (1978) Human gastric atony with tachy-gastria and gastric retention. Gastroenterology 75:497–501

    PubMed  CAS  Google Scholar 

  10. Fleckenstein P, Oigaard A (1978) Electrical spike activity in the human small intestine. Am J Dig Dis 23:776–780

    Article  PubMed  CAS  Google Scholar 

  11. Weisbrodt NW (1987) Motility of the small intestine. In: Johnson LR (ed) physiology of the gastrointestinal tract. 2 edn. Raven, New York

    Google Scholar 

  12. Sarna S (1985) Cyclic motor activity: migrating motor complex. Gastroenterology 89: 894–913

    PubMed  CAS  Google Scholar 

  13. Malagaleda JR, Camilleri M (1985) Disorders of motility of the stomach. In: Berk JE (ed) Bockus gastroenterology, 4 edn. Saunders, Philadelphia, chap 76

    Google Scholar 

  14. Avots-Avotins AE, Ashworth WD, Stafford BD, Moore JG (1990) Day and night esophageal motor function. Am J Gastroenterol 85 (6): 683–685

    PubMed  CAS  Google Scholar 

  15. Gregory PC, Rayner DV, Wenham G (1984) Initiation of migrating myoelectric complex in sheep by duodenal acidification and hyperosmolarity: role of vagus nerves. J Physiol 355:509–521

    PubMed  CAS  Google Scholar 

  16. Moore JG (1973) High gastric acid after vagotomy and pyloroplasty in man. Evidence for non-vagal mediation. Am J Dig Dis 18: 661–669

    Article  PubMed  CAS  Google Scholar 

  17. Markiewicz A, Semenowicz K (1979) Time dependent changes in the pharmacokinetics of aspirin. Int J Clin Pharmacol Biopharm 17: 409–411

    PubMed  CAS  Google Scholar 

  18. Kyle GM, Smolensky MH, Thorne LG, Hsi BP, Robison A, McGovern JP (1986) Circadian rhythm in the pharmacokinetics of orally administered theophylline. In: Smolensky MH, Reinberg A, McGovern JP (eds) Recent advances in the chronobiology of allergy and immunology. Pergamon, Oxford

    Google Scholar 

  19. Reinberg A, Clench J, Aymard N, Gaillot M, Bourdon R, Gervais P, Abulker C, Dupont J (1975) Variation circa-diennes des effects de l’ethanolemie chez l’homme adulte sain (etude chronopharmacologique). J Physiol (Paris) 70: 1–22

    Google Scholar 

  20. Reinberg A, Levi F, Toviton Y, Leliboux A, Simon A, Frydman A, Bickora-Rocher A, Bruguerolle B (1986) Clinical chronokinetic changes in a sustained release preparation of ketoprofen (SRK). Annu Rev Chronopharmacol 3: 317–320

    CAS  Google Scholar 

  21. Graham DY, Smith JL (1986) Aspirin and the stomach. Ann Intern Med 104: 390–398

    PubMed  CAS  Google Scholar 

  22. Katz KA, Sunshine AG, Cohen S (1987) The effect of nonsteroidal antiinflammatory drugs on upper gastrointestinal symptoms and mucosal integrity. J Clin Gastroenterol 92 (2): 142–148

    Article  Google Scholar 

  23. Huskisson EC (1976) Chronopharmacology of anti-rheumatic drugs with special reference to indomethacin. In: Huskisson EC, Velo GP (eds) Inflammatory arthropathies. Ex-cerpta Medica, Amsterdam

    Google Scholar 

  24. Levi F, LeLouarn C, Reinberg A (1984) Chronotherapy of osteo arthritic patients: optimization of indomethacin sustained release (ISR). Annu Rev Chronopharmacol 1: 345–348

    Google Scholar 

  25. Moore JG, Goo RH (1987) Day and night aspirin-induced gastric mucosal damage and protection by ranitidine in man. Chronobiol Int 4 (Ulcerogenesis suppl): 111–116

    Article  PubMed  CAS  Google Scholar 

  26. Ventura U, Carandente F, Montini E, Ceriani T (1987) Circadian rhythmicity of acid secretion and electrical function in intact and injured rat mucosa - the relation of timing to ulcerogenesis. Chronobiol Int 4 (Ulcerogenesis suppl): 43–52

    Article  PubMed  CAS  Google Scholar 

  27. Szabo S, Pfeiffer DC, Oishi T (1986) The pharmacology of drug induced gastric and duodenal ulcers. Annu Rev Chronopharmacol 3: 383–384

    Google Scholar 

  28. Moore JG, Halberg F (1986) Circadian rhythm of gastric acid secretion in men with active duodenal ulcer. Dig Dis Sci 31 (11): 1185–1191

    Article  PubMed  CAS  Google Scholar 

  29. Moore JG, Wolfe ME (1974) Circadian plasma gastrin levels in feeding and fasting man. Digestion 11: 226–232

    Article  PubMed  CAS  Google Scholar 

  30. Sanders SW, Moore JG, Buchi KN, Bishop AL (1988) Circadian variation in the pharmacodynamic effect of intravenous ranitidine. Annu Rev Chronopharm 5: 335–338

    Google Scholar 

  31. Fimmel CJ, Etienne A, Cillufo T, Ritter C, Gasser T, Rey JP, Caradonna-Moscatelli P, Sabbitini F, Pace F, Buhler HW, Bauerfind P, Blum AL (1985) Long-term ambulatory gastric pH monitoring: validation of a new method and effect of H2-antagonists. Gastroenterology 88 (6): 1842–1851

    PubMed  CAS  Google Scholar 

  32. Ballesteros MA, Hogan DL, Koss MA, Isenberg JI (1990) Bolus or intravenous infusion of ranitidine: effects on gastric pH and acid secretion: a comparison of cost and relative efficacy. Ann Intern Med 112: 334–339

    PubMed  CAS  Google Scholar 

  33. Merki HS, Witzel L, Kaufman D, Kempf M, Neuman J, Rohmel J, Walt RP (1988) Continuous infusion of famotidine maintains high intragastric pH in duodenal ulcer. Gut 29: 453–457

    Article  PubMed  CAS  Google Scholar 

  34. Smolensky MH, McGovern JP, Scott PH, Reinberg A (1987) Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medication. J Asthma 24 (2): 91–134

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. J. G. Moore
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Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

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© 1992 Springer-Verlag Berlin Heidelberg

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Moore, J.G. (1992). Chronobiology of the Gastrointestinal System. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_30

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  • DOI: https://doi.org/10.1007/978-3-642-78734-8_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78736-2

  • Online ISBN: 978-3-642-78734-8

  • eBook Packages: Springer Book Archive

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