Biological Rhythms in Hepatic Drug Metabolism and Biliary Systems

  • P. M. Bélanger
  • G. Labrecque


The liver is the largest organ in mammals and has many complex metabolic functions. These include the metabolism and storage of carbohydrates, lipids, minerals, proteins, hormones, and vitamins, the formation of bile, and the synthesis of blood coagulation factors and plasma proteins. One liver function that is very important in pharmacology is the biotransformation of drugs and toxic agents into metabolites that are more readily excreted into the bile or urine. In some cases, the liver metabolizes exogenous compounds into pharmacologically active products (Drayer 1976, 1982; Garattini 1985) or into chemical intermediates which could react with biological macromolecules to cause cellular necrosis (Connors 1976; Drayer 1976, 1982; Boyd et al. 1983; Anders 1985).


Biliary Excretion Circadian Variation Allyl Alcohol Biological Rhythm Hepatic Drug Metabolism 
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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • P. M. Bélanger
  • G. Labrecque

There are no affiliations available

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