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Biologic Rhythms in Clinical and Laboratory Medicine pp 386–402Cite as

Endocrine and Neuroendocrine Axis Testing in Clinical Medicine: Evidence for Time Dependency

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Abstract

Numerous tests are used in clinical practice to assess the integrity of different parts of the endocrine and neuroendocrine systems. In these procedures the relationship between the inhibitory or activating effect of the diagnostic agent and the plasma concentration of the responding hormone are most often considered, without any regard to temporal aspects. As will be shown in this review, however, the time of testing represents a variable of great importance in the interpretation of the data. Furthermore, the time-related differences in the effects of the drugs used as diagnostic but also as therapeutic agents may be critical in the interpretation of both stimulation and suppression tests of endocrine and neuroendocrine functions (Touitou 1989).

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Authors
  1. Y. Touitou
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  2. A. Bogdan
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Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

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© 1992 Springer-Verlag Berlin Heidelberg

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Touitou, Y., Bogdan, A. (1992). Endocrine and Neuroendocrine Axis Testing in Clinical Medicine: Evidence for Time Dependency. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_28

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  • DOI: https://doi.org/10.1007/978-3-642-78734-8_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78736-2

  • Online ISBN: 978-3-642-78734-8

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