Chronobiology, Nutrition, and Diabetes Mellitus

  • L. Méjean
  • M. Kolopp
  • P. Drouin


Blood glucose levels are commonly used as a marker of carbohydrate metabolism, and subsequent oscillations are related to various phenomena. Blood glucose levels are controlled by several hormones, i.e., insulin and the counterregulatory hormones. The circulating levels and the metabolic action of these hormones undergo different cyclic variations (Aparicio et al. 1974; Hautecouverture et al. 1975; Hoist et al. 1983; Lefebvre et al. 1987; Waldhausl 1989). These cyclic oscillations may influence the hormonal action on glucose consumption by peripheral tissues, glycogen degradation, and gluconeogenesis. The exogenous supply of glucose depends on food intake, produced by a food behavior which is regulated by pre- and periingestive factors which may stimulate or inhibit any motivation states such as hunger, satiety, satiation, or appetite (Nicolaïdis and Burlet 1988).


Circadian Rhythm Diurnal Variation Circadian Variation Insulin Requirement Insulin Binding 
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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. Méjean
  • M. Kolopp
  • P. Drouin

There are no affiliations available

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