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Chronobiology of the Hypothalamic-Pituitary-Thyroid Axis

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Biologic Rhythms in Clinical and Laboratory Medicine

Abstract

The hypothalamic-pituitary-thyroid (HPT) axis is part of a complex web of neuroendocrine functions. It shows an intricate time structure with rhythmic variations of multiple frequencies found at all levels of the system from hypothalamic neurons to the cells of the peripheral target tissues. The frequencies observed range from rapid neuronal discharges to ultra-dian rhythms, and/or pulsatile secretions to circadian and circannual rhythms. The rhythmic variations are superimposed upon aging trends. The time-dependent rhythmic (and nonrhythmic) variations of the HPT system interact with, modulate and are modulated by similar time-dependent variations of other neuroendocrine, metabolic and immune functions.

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Authors
  1. G. Y. Nicolau
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  2. E. Haus
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Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

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© 1992 Springer-Verlag Berlin Heidelberg

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Nicolau, G.Y., Haus, E. (1992). Chronobiology of the Hypothalamic-Pituitary-Thyroid Axis. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_24

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  • DOI: https://doi.org/10.1007/978-3-642-78734-8_24

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