Abstract
Variations in plasma hormone concentrations have been studied extensively in various conditions of health and disease in the human and experimental animals. A wide range of environmental, metabolic, nutrient, and hormonal stimuli are known to modulate normal patterns of anterior pituitary hormone release and/or alter the metabolic clearance of the endocrine effector substance. The ability to evaluate quantitatively not only variations in plasma hormone concentrations but also regulated features of hormone secretory events has been acquired recently through the use of so-called deconvolution techniques [20, 26, 32, 36, 41, 48, 54, 56, 60, 62, 72, 71, 74]. Deconvolution represents a procedure in which available plasma hormone concentration measurements are interpreted mathematically as the specific consequence of definable secretory events and hormone-specific metabolic clearance. The examination of calculated in vivo secretory events is of particular importance pathophysiologically, when a clinician and investigator wish to assess regulation of the actual secretory behavior of the endocrine gland. In contrast, evaluation of plasma hormone concentrations in the conventional manner discloses information about the hormonal milieu to which the target gland is exposed. Although the majority of available clinical investigative work has focused on variations in plasma hormone concentrations (and hence, the signal made available to the target tissue), recent advances in analytical tools have allowed detailed studies of the secretory rhythms inherent in the regulated output of the endocrine gland. Accordingly, here we will emphasize not rhythms in pituitary hormone concentrations in plasma, but rhythms in the secretory behavior of the anterior pituitary gland under a range of normal and pathological conditions in man.
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Alford FP, Baker HWG, Burger HG, deKretser DM, Hudson B, Johns MW, Masterton JP, Patel YC, Rennie GC (1973) Temporal patterns of integrated plasma hormone levels during sleep and wakefulness. I. Thyroid-stimulating hormone, growth hormone and Cortisol. J Clin Endocrinol Metab 37: 841–847
Antoni FA (1986) Hypothalamic control of adrenocortico-tropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr Rev 7: 351–378
Asplin CM, Faria ACS, Carlsen EC, Vaccaro VA, Barr RE, Iranmanesh A, Lee MM, Veldhuis JD, Evans WS (1989) Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 69: 239–245
Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L (1972) Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N Engl J Med 287: 582–586
Brabant G, Brabant A, Ranft U, Ocran K, Kohrle J, Hesch RD, von zur Muhlen A (1987) Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration. J Clin Endocrinol Metab 65: 83–88
Butler JP, Spratt DI, O’Dea LS, Crowley WF Jr (1986) Interpulse interval sequence of LH in normal men essentially constitutes a renewal process. Am J Physiol 250: E338-E340
Carnes M, Kalin NH, Lent SJ, Barksdale CM, Brownfield MS (1988) Pulsatile ACTH secretion: variation with time of day and relationship to Cortisol. Peptides 9: 325–331
Chan V, Jones A, Liendo-Ch P, McNeilly A, Landon J, Besser GM (1978) The relationship between circadian variations in circulating thyrotrophin, thyroid hormones and prolactin. Clin Endocrinol 9: 337–349
Clayton GW, Librik L, Gardner RL, Guillemin R (1973) Studies on the circadian rhythm of pituitary adrenocorti-cotropin release in man. J Clin Endocrinol Metab 23: 975–981
Czeisler CA, Weitzman ED, Moore-Ede MC, Zimmerman JC, Kronauer RS (1980) Human sleep, its duration and organization depend on its circadian phase. Science 210:1264–1267
Desir D, van Cauter E, Goldstein J, Fang VS, Leclercq R, Refetoff S, Copinschi G (1980) Circadian and ultradian variations of ACTH and Cortisol secretion. Horm Res 13: 302–316
Desir D, van Cauter E, L’Hermite M, Retetoff S, Jadot C, Caufriez A, Copinschi G, Robyn C (1982) Effects of “jet lag” on hormonal patterns. III. Demonstration of an intrinsic circadian rhythmicity in plasma prolactin. J Clin Endocrinol Metab 55: 849–856
Follenius M, Brandenberger G, Simeoni M, Reinhardt B (1982) Diurnal Cortisol peaks and their relationships to meals. J Clin Endocrinol Metab 55: 757–761
Frantz AG (1979) Rhythms in prolactin secretion. In: Krieger DT (ed) Endocrine rhythms. Raven, New York, pl75
Gallagher TF, Yoshida K, Roffwarg HD, Fukushida DK, Weitzman ED, Hellman L (1973) ACTH and Cortisol secretory patterns in man. J Clin Endocrinol Metab 36:1058–1073
Gambacciani M, Liu JH, Swartz WH, Tueros VS, Ras-mussen DD, Yen SSC (1987) Intrinsic pulsatility of ACTH release from the human pituitary in vitro. Clin Endocrinol 26: 557–563
Graber AL, Givens JR, Nicholson WE, Island DP, Liddle GW (1965) Persistence of diurnal rhythmicity in plasma ACTH concentrations in cortisol-deficient patients. J Clin Endocrinol Metab 25: 804–807
Hartman ML, Faria ACS, Vance ML, Johnson ML, Thorner MO, Veldhuis JD (1991) Temporal structure of in vivo growth hormone secretory events in man. Am J Physiol 260: E101-E110
Hartman ML, Veldhuis JD, Vance ML, Faria ACS, Furla-netto RW, Thorner MO (1990) Somatotropin pulse frequency and basal growth hormone concentrations are increased in acromegaly. J Clin Endocrinol Metab 70: 1375–1384
Henery RJ, Turnbull BA, Kirkl M, McArthur JW, Gilbert I, Besser GM, Rees LH, Pedoe DST (1989) The detection of peaks in luteinizing hormone secretion. Chronobiol Int 6: 259–265
Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KGMM, Thorner MO (1988) Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 81: 968–975
Iranmanesh A, Lizarralde G (1989) Primary hypothyroidism alters the pulsatile mode of LH and FSH release by amplitude modulation (Abstr 113A). 71 Annual Meeting of the Endocrine Society, Seattle
Iranmanesh A, Lizarralde G, Johnson ML, Veldhuis JD (1989) Circadian, ultradian and episodic release of beta-en-dorphin in men, and its temporal coupling with Cortisol. J Clin Endocrinol Metab 78:1019–1026
Johnson ML, Lassiter AE, Veldhuis JD (1990) A waveform-independent deconvolution technique to analyze in vivo hormone secretion (Abstr 905). 72nd Annual Meeting of the Endocrine Society, Atlanta
Judd HL (1979) Biorhythms of gonadotropins and testicular hormone secretion. In: Krieger DT (ed) Endocrine rhythms. Raven, New York, p 299
Jusko WJ, Slaunwhite WR, Aceto T (1975) Partial pharmacodynamic model for the circadian-episodic secretion of Cortisol in man. J Clin Endocrinol Metab 40: 278–289
Kapen S, Boyar RM, Finkelstein JW, Hellman L, Weitzman ED (1974) Effect of sleep-wake cycle reversal on luteinizing hormone secretory pattern in puberty. J Clin Endocrinol Metab 39: 293–299
Keller-Wood ME, Dallman MF (1984) Corticosteroid inhibition of ACTH secretion. Endocr Rev 5:1–24
Krieger DT (1979) Rhythms in CRF, ACTH and corticosteroids. In: Krieger DT (ed) Endocrine rhythms. Raven, New York, pp 123–142
Krieger DT, Aschoff J (1979) Endocrine and other biological rhythms. Endocrinology 11: 2079
Liddle GW, Island D, Meador CK (1962) Normal and abnormal regulation of corticotropin secretion in man. Recent Prog Horm Res 18:125–166
Linkowski P, Mendlewicz J, Leclercq R, Brasseur M, Hu-bain P, Golstein J, Copinschi G, van Cauter E (1985) The 24-hour profile of adrenocorticotropin and Cortisol in major depressive illness. J Clin Endocrinol Metab 61: 429–438
Martha PM, Rogol AD, Veldhuis JD, Kerrigan JR, Goodman DW, Blizzard RM (1989) Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J Clin Endocrinol Metab 69: 563–570
Mauras N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD (1987) Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 64: 596–601
Mauras N, Rogol AD, Veldhuis JD (1989) Specific, time dependent actions of low-dose estradiol administration on the episodic release of GH, FSH, and LH in prepubertal girls with Turner’s syndrome. J Clin Endocrinol Metab 69:1053–1058
Mcintosh RP, Mcintosh JEA (1985) Amplitude of episodic release of LH as a measure of pituitary function analysed from the time-course of hormone levels in the blood: comparison of four menstrual cycles in an individual. J Endocrinol 107: 231–239
Mcintosh RP, Mcintosh JEA, Lazarus L (1988) A comparison of the dynamics of secretion of human growth hormone and LH pulses. J Endocrinol 118: 339–345
Moore-Ede MC, Czeisler CA, Richardson GS (1983) Circadian timekeeping in health and disease. N Engl J Med 309: 469, 530
Mortola JF, Liu JH, Gillen JC, Rasmussen DD, Yen SSC (1987) Pulsatile rhythms of adrenocorticotropin (ACTH) and Cortisol in women with endogenous depression: evidence for increased ACTH pulse frequency. J Clin Endocrinol Metab 65: 962–968
Negro-Vilar A, Johnston CA, Spinedi E, Valenca M, Lopez F (1987) Physiological role of peptides and amines in the regulation of ACTH secretion. Ann NY Acad Sci 512: 218
Oerter KE, Guardabasso V, Rodbard D (1986) Detection and characterization of peaks and estimation of instantaneous secretory rate for episodic pulsatile hormone secretion. Comput Biomed Res 19:170–191
O’Sulivan F, O’Sullivan J (1988) Deconvolution of episodic hormone data: an analysis of the role of season on the onset of puberty in cows. Biometrics 44: 339–353
Parker DC, Rossman LG, Vanderlaan EF (1973) Sleep-related nyctohemeral and briefly episodic variation in human plasma prolactin concentrations. J Clin Endocrinol Metab 36:1119–1124
Parker DC, Pekary AE, Hershman JM (1976) Effect of normal and reversed sleep-wake cycles upon nyctohemeral rhythmicity of plasma thyrotropin. Evidence suggestive of an inhibitory influence in sleep. J Clin Endocrinol Metab 43: 318–329
Parker DC, Rossman LG, Pekary AE, Hershman JM (1987) Effect of 64-hour sleep deprivation on the circadian waveform of thyrotropin (TSH): further evidence of sleep-related inhibition of TSH release. J Clin Endocrinol Metab 64:157–161
Patel YC, Alford FP, Burger HG (1972) The 24-hour plasma thyrotrophin profile. Clin Sci 43: 71–77
Plotsky PM, Vale W (1986) Patterns of growth hormone-releasing factor and somatostatin secretion into the hypo-physial-portal circulation of the rat. Science 230: 461–465
Rebar R, Perlman D, Naftolin F, Yen SSC (1973) The estimation of pituitary luteinizing hormone secretion. J Clin Endocrinol Metab 37: 917–927
Sassin JF, Frantz AG, Kapen S, Weitzman ED (1973) The nocturnal rise of human prolactin is dependent on sleep. J Clin Endocrinol Metab 37:436–440
Shin SH, Reifel CW (1981) Adenohypophysis has an inherent property for pulsatile prolactin secretion. Neuroendocri-nology 32:139–144
Sollenberger ML, Carlson EC, Veldhuis JD, Evans WS (1990) Nature of LH secretory events throughout the human menstrual cycle. J Neuroendocrinol 2: 845–852
Sowers JR, Catania RA, Hershman JM (1982) Evidence for dopaminergic control of circadian variations in thyrotropin secretion. J Clin Endocrinol Metab 54: 673–675
Stewart JK, Clifton DK, Koerker DJ, Rogol AD, Jaffe T, Goodner CJ (1985) Pulsatile release of growth hormone and prolactin from the primate pituitary in vitro. Endocrinology 116:1–5
Swartz CM, Wahby VS, Vacha R (1986) Characterization of the pituitary response in the TRH test by kinetic modeling. Acta Endocrinol (Copenh) 112: 43–48
Thorner MO (1992) The adenohypophysis. In: Williams RH (ed) Textbook of endocrinology. Saunders, Philadelphia
Toutain PL, Laurentie M, Autefage A, Alvinerie M (1988) Hydrocortisone secretion: production rate and pulse characterization by numerical deconvolution. Am J Physiol 255: E688-E695
Ulloa-Aguirre A, Blizzard RM, Garcia-Rubi E, Rogol AD, Link K, Christie CM, Johnson ML, Veldhuis JD (1990) Testosterone and oxandrolone, a non-aromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life. J Clin Endocrinol Metab 71: 846–854
Urban RJ, Veldhuis JD (1988) Hypothalamo-pituitary concomitants of aging. In: Sowers JR, Felicetta JV (eds) The endocrinology of aging. Raven, New York, pp 41–74
Urban RJ, Veldhuis JD (1991) Modulating effects of dihy-drotestosterone and estradiol on the dynamics of FSH secretion and clearance in young men. J Androl 12: 27–35
Urban RJ, Evans WS, Rogol AD, Johnson ML, Veldhuis JD (1988) Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9: 3–37
Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML (1988) Attenuated release of biologically active luteinizing hormone in healthy aging men. J Clin Invest 81:1020–1029
Van Cauter E (1979) Method for characterization of 24-hour temporal variation of blood components. Am J Physiol 237: E255-E264
Van Cauter E, Refetoff S (1985) Multifactorial control of the 24-hour secretory profiles of pituitary hormones. J Endocrinol Invest 8: 381–391
Van Cauter E, Leclercq R, Vanhaelst L, Golstein J (1974) Simultaneous study of Cortisol and TSH daily variations in normal subjects and patients with hyperadrenalcorticism. J Clin Endocrinol Metab 39: 645–652
Van Cauter E, L’Hermite M, Copinschi G, Refetoff S, Desir D, Robyn C (1981) Quantitative analysis of spontaneous variations of plasma prolactin in normal man. Am J Physiol 241: E355-E363
Vanhaelst L, van Cauter E, Degaute JP, Golstein J (1972) Circadian variations of serum thyrotropin levels in man. J Clin Endocrinol Metab 35: 479–482
Veldhuis JD (1989) Mean plasma hormone concentration is controlled in a linear manner by secretory impulse frequency. Am J Physiol 257: E299-E300
Veldhuis JD, Evans WS (1989) Mechanisms subserving estradiol’s induction of increaed prolactin concentrations in man: evidence for amplitude modulation of spontaneous prolactin secretory bursts. Am J Obstet Gynecol 161:1149–1158
Veldhuis JD, Johnson ML (1988) A novel general biophysical model for simulating episodic endocrine gland signaling. Am J Physiol 255 (18): E749-E759
Veldhuis JD, Johnson ML (1988) In vivo dynamics of luteinizing hormone secretion and clearance in man: assessment by deconvolution mechanics. J Clin Endocrinol Metab 66: 1291–1300
Veldhuis JD, Johnson ML (1990) New methodological aspects of evaluating episodic neuroendocrine signals. In: Yen SSC, Vale W (eds) Advances in neuroendocrine regulation of reproduction. Plenum, New York, p 123–139
Veldhuis JD, Carlson ML, Johnson ML (1987) The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter de-convolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686–7690
Veldhuis JD, Clifton D, Crowley WF, Cutle GB, Filicori M, Johnson ML, Maciel RJ, Merriam GR, Santoro MF, Steiner RA, Santen RJ (1988) Preferred attributes of objective pulse analysis methods. In: Crowley WF, Hofler JG (eds) The episodic secretion of hormones. Wiley, New York, pp 111–118
Veldhuis JD, Faira A, Vance ML, Evans WS, Thorner MO, Johnson ML (1988) Contemporary tools for the analysis of episodic growth hormone secretion and clearance in vivo. Acta Paediatr Scand 347: 63–82
Veldhuis JD, Iranmanesh A, Clarke I, Kaiser DL, Johnson ML (1989) Random and non-random coincidence between LH peaks and FSH, alpha subunit, prolactin, and GnRH pulsations. J Neuroendocrinol 1:1–10
Veldhuis JD, Iranmanesh A, Lizarralde G, Johnson ML (1989) Amplitude modulation of a burst-like mode of Corti-sol secretion gives rise to the nyctohemeral glucocorticoid rhythm in man. Am J Physiol 257: E6-E14
Veldhuis JD, Johnson ML, Dufau ML (1989) Physiological attributes of endogenous bioactive luteinizing hormone secretory bursts in man: assessment by deconvolution analysis and in vitro bioassay of LH. Am J Physiol 256: E199-E207
Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G (1990) Amplitude, but not frequency, modulation of ACTH secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man. J Clin Endocrinol Metab 71: 452–463
Veldhuis JD, Iranmanesh A, Ho KKY, Lizarralde G, Waters MJ, Johnson ML (1991) Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomato-tropism of obesity in man. J Clin Endocrinol Metab 72: 51–59
Veldhuis JD, Johnson ML, Iranmanesh A, Lizarralde G (1990) Temporal structure of in vivo adrenal secretory activity estimated by deconvolution analysis. J Biol Rhythms 5: 247–255
Watanabe T, Orth DN (1987) Detailed kinetic analysis of adrenocorticotropin secretion by dispersed anterior pituitary cells in a microperifusion system: effects of ovine corti-cotropin-releasing factor and arginine vasopressin. Endocrinology 121:1133–1145
Weeke J, Gundersen HJG (1978) Circadian and 30 minute variations in serum TSH and thyroid hormones in normal subjects. Acta Endocrinol (Copenh) 89: 659–672
Weitzman ED (1976) Circadian rhythms and episodic hormone secretion in man. Annu Rev Med 27: 225–243
Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher TF, Hellman L (1971) Twenty-four hour pattern of the episodic secretion of Cortisol in normal subjects. J Clin Endocrinol Metab 33:14–22
Weitzman ED, Nogeire C, Perlow M, Fukushima D, Sassin J, McGregor P, Gallagher TF, Hellman L (1974) Effects of a prolonged 3-hour sleep-wake cycle on sleep stages, plasma Cortisol, growth hormone and body temperature in man. J Clin Endocrinol Metab 38:1018–1030
Winters SJ (1990) Inhibin is released together with testosterone by the human testis. J Clin Endocrinol Metab 70: 548–550
Winters SJ, Troen PE (1986) Testosterone and estradiol are co-secreted episodically by the human testis. J Clin Invest 78: 870–872
Yates FE, Maran JW (1980) Stimulation and inhibition of adrenocorticotropin release. In: Knobil E, Sawyer CW (eds) The pituitary gland and its neuroendocrine control, part 2. American Physiological Society, Washington, pp 367–404 (Handbook of physiology, vol 4)
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Veldhuis, J.D., Johnson, M.L., Iranmanesh, A., Lizarralde, G. (1992). Rhythmic and Nonrhythmic Modes of Anterior Pituitary Hormone Release in Man. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_21
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