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Regulation der exokrinen Pankreassekretion

  • Conference paper
Ökosystem Darm V

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Zusammenfassung

Diese Übersicht analysiert den aktuellen Wissensstand über die Regulation der exokrinen Pankreasfunktion. Die unterschiedlichen stimulierenden und hemmenden Regulationsmechanismen spielen sich dabei auf verschiedenen Ebenen ab (s. folgende Übersicht).

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Literatur

  1. Adler G, Reinshagen M, Koop I et al. (1989) Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion. Gastroenterology 96: 1158–1164

    PubMed  CAS  Google Scholar 

  2. Adler G, Beglinger C, Braun U et al. (1991) Interaction of the cholinergic system and cholecystokinin in the regulation of endogenous and exogenous stimulation of pancreatic secretion in humans. Gastroenterology 100: 537–543

    PubMed  CAS  Google Scholar 

  3. Alphin RS, Lin TM (1959) Effect of feeding and sham feeding on pancreatic secretion of the rat. Am J Physiol 197: 260

    PubMed  CAS  Google Scholar 

  4. Anagostideo A, Chadwick, Seiden VS et al. (1984) Sham feeding and pancreatic secretion. Evidence for direct vagal stimulation of output. Gastroenterology 87: 109

    Google Scholar 

  5. Beglinger C, Grossmann MI, Solomon TE (1984) Interaction between stimulants of exocrine pancreatic secretion in dogs. Am J Physiol 246: G173

    PubMed  CAS  Google Scholar 

  6. Beglinger C, Fried M, Whitehouse I et al. (1985) Pancreatic enzyme responses to a liquid meal and to hormonal stimulation. Correlation with plasma secretin and cholecystokinin levels. J Clin Invest 75: 1471

    Article  PubMed  CAS  Google Scholar 

  7. Bergmann RN, Miller RE (1973) Direct enhancement of insulin secretion by vagal stimulation of the isolated pancreas. Am J Physiol 225: 481

    Google Scholar 

  8. Bockman DE, Büchler M, Malfertheiner P, Beger HG (1990) Morphology of nerves in chronic pancreatitis and in the interrelationship with inflammatory tissue. In: Beger HG, Büchler M, Ditschuneit H, Malfertheiner P (Hrsg) Chronic pancreatitis. Springer, Berlin Heidelberg New York Tokyo, pp 72–82

    Google Scholar 

  9. Chey WY, Lee YH, Hendricks JG et al. (1978) Plasma secretin concentrations in fasting and postprandial state in man. Dig Dis Sci 23: 981

    Article  CAS  Google Scholar 

  10. Chey WY, Kim MS, Lee KY et al. (1979) Effect of rabbit antisecretin serum on postprandial pancreatic secretion in dogs. Gastroenterology 77: 1268

    PubMed  CAS  Google Scholar 

  11. Chey WY, Lee KY, Chang T et al. (1984) Potentiating effect of secretin on cholecystoki- nin-stimulated pancreatic secretion in dogs. Am J Physiol 246: G248

    PubMed  CAS  Google Scholar 

  12. Defillipi C, Solomon TE, Valenzuela JE (1982) Pancreatic secretory response to sham feeding in humans. Digestion 23: 217

    Article  Google Scholar 

  13. DeMar AR, Lake R, Fink AS (1991) The effect of pancreatic polypeptide and peptide Y on pancreatic blood flow and pancreatic exocrine secretion in the anesthetized dog. Pancreas 6: 9–14

    Article  PubMed  CAS  Google Scholar 

  14. Dooley CP, Valenzuela JE (1984) Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion. Gastroenterology 96: 23

    Google Scholar 

  15. Frier BM, Adrian TE, Saunders JHB, Bloom SR (1980) Serum trypsin concentration and pancreatic trypsin secretion in insulindependent diabetes mellitus. Clin Chim Acta 105: 297–300

    Article  PubMed  CAS  Google Scholar 

  16. Goldfine ID, Williams JA (1983) Receptors for insulin and CCK in the acinar pancreas: relationship to hormone action. Int Rev Cytol 85: 1–38

    Article  PubMed  CAS  Google Scholar 

  17. Green GM, Lyman RL (1972) Feedback regulation of pancreatic enzymes secretion as a mechanism for trypsin inhibitor-induced hypersecretion in rats. Proc Soc Exp Biol Med 140: 6–12

    PubMed  CAS  Google Scholar 

  18. Harper AA, Hood AJC, Mushens J (1979) Pancreatone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa. J Physiol 292: 455

    PubMed  CAS  Google Scholar 

  19. Ishizuka J, Asada I, Poston GJ, Lluis F, Tatemoto K, Greeley GH jr., Thomson JC (1989) Effect of pancreastatin on pancreatic endocrine and exocrine secretion. Pancreas 4: 277–281

    Article  PubMed  CAS  Google Scholar 

  20. Johnson CD, Devaux MA, Treffot MJ, Sarles H (1991) The cephalogastric phase of the pancreatic response to food in the dog. Pancreas 6: 190–196

    Article  PubMed  CAS  Google Scholar 

  21. Jung G, Louis DS, Owyang C (1987) Pancreatic polypeptide inhibits pancreatic enzyme secretion via a cholinergic pathway. Am J Physiol 253: G706

    PubMed  CAS  Google Scholar 

  22. Karaus M, Niederau C (1991) Effects of CCK antagonists on intestinal motility in dogs. In: Adler G, Beglinger C (eds.). Cholecystokinin antagonists in gastroenterology. SpringerVerlag Berlin Heidelberg 165–172

    Google Scholar 

  23. Katschinski M (1991) The role of CCK and CCK antagonists in human esophageal and gastroduodenal motility. In: Adler G, Beglinger C (Hrsg.). Cholecystokinin antagonists in gastroenterology. Springer-Verlag Berlin Heidelberg 173–182

    Google Scholar 

  24. Katschinski M, Langbein S, Dahmen G, Arnold R, Beglinger C, Adler G (1992) Die Regulation der interdigestiven antroduodenalen Motilität des Menschen durch das cholinerge Nervensystem und Cholecystokinin. Z Gastroenterol 30: A638

    Google Scholar 

  25. Kirchgessner AI, Gershon MD (1989) Innervation of the rats pancreas: analysis of direct projections from neurons in myenteric ganglia of the duodenum and stomach and intra- pancreatic ganglia. Gastroenterology 96: A258

    Google Scholar 

  26. Köhler N, Nustede R, Barthel M, Schafmayer A (1992) Einfluß der extrinsischen Denervation des Pankreas auf die nahrungsstimulierte Pankreassekretion und die Freisetzung von Cholezystokinin und Neurotensin beim Hund. Z Gastroenterol 30: 125–129

    PubMed  Google Scholar 

  27. Lankisch PG, Manthey G, Otto J, Koop H, Talaulicar M, Willms B, Creutzfeldt W (1982) Exocrine pancreatic function in insulin-dependent diabetes mellitus. Digestion 25: 211–216

    Article  PubMed  CAS  Google Scholar 

  28. Larsson L, Rehfield JF (1979) Peptidergic and adrenergic innervation of pancreatic ganglia. Scand J Gastroenterol 14: 433

    PubMed  CAS  Google Scholar 

  29. Layer P, Chan ATH, Go VLW, Zinsmeister AR, DiMagno EP (1992) Adrenergic modulation of interdigestive pancreatic secretion in humans. Gastroenterology 103: 990–993

    PubMed  CAS  Google Scholar 

  30. Layer P (1992) Intestinale Regulation der Pankreasenzymsekretion: Stimulatorische und inhibitorische Mechanismen. Z Gastroenterol 30: 495–497

    PubMed  CAS  Google Scholar 

  31. Malagelada JR, Go VLW, Summerskill WMJ (1974) Altered pancreatic and biliary function after vagotomy and pyloroplasty. Gastroenterology 66: 22

    PubMed  CAS  Google Scholar 

  32. Meade RC, Kneubuhler HA, Schulte WJ, Barboiak JJ (1967) Stimulation of insulin secretion by pancreozymin. Diabetes 16: 141–147

    PubMed  CAS  Google Scholar 

  33. Meyer JH, Fink AS (1984) Pancreatic bicarbonate response to foodbound hydrogen ion along the gut. Gastroenterology 87: 587

    Google Scholar 

  34. Miyasaka K, Green GM (1984) Effect of partial exclusion of pancreatic juice of rat basal pancreatic secretion. Gastroenterology 86: 114–119

    PubMed  CAS  Google Scholar 

  35. Niederau C, Heintges T, Rovati L, Strohmeyer G (1989) Effects of loxiglumide on gallbladder emptying after a meal or after intravenous infusion of caerulein in healthy human volunteers. Gastroenterology 97: 1331–1337

    PubMed  CAS  Google Scholar 

  36. Niederau C, Niederau M, Lüthen R, Grendell JG (1990) Influence of cholecystokinin receptor antagonists on feedback regulation of pancreatic secretion. In: Beger HG, Büchler M, Ditschuneit H, Malfertheiner P (Hrsg.). Chronic pancreatitis. Springer-Verlag Berlin Heidelberg 185–197

    Chapter  Google Scholar 

  37. Niederau C, Niederau M, Lüthen R, Strohmeyer G, Grendell JH (1991) Effects of Cholezystokinin receptor antagonists in animal models. In: Adler G, Beglinger C (Hrsg.). Cholecystokinin antagonists in gastroenterology. Springer-Verlag Berlin Heidelberg 112–126

    Google Scholar 

  38. Niederau C, Schwarzendrube J, Lüthen R, Niederau M, Strohmeyer G, Rovati L (1992) Effects of cholecystokinin receptor blockade on circulating concentrations of glucose, insulin, C-peptide, and pancreatic polypeptide after various meals in healthy human volunteers. Pancreas 7: 1–10

    Article  PubMed  CAS  Google Scholar 

  39. Novis BM, Bank S, Marks IN (1971) the cephalic phase of pancreatic secretion in man. Scand J Gastroenterol 6: 417

    Article  PubMed  CAS  Google Scholar 

  40. Owyang C, Williams J (1991) Pancreatic secretion. In: Yamada T, Alpers DH, Owyang C, Powell DW, Silverstein FE (Hrsg.) Textbook of Gastroenterology. Lippincott Company, Philadelphia 294–314

    Google Scholar 

  41. Otsuki M, Williams JA (1982) Effect of diabetes mellitus on the regulation of enzyme secretion by isolated rat pancreatic acini. J Cin Invest 70: 148–156

    Article  CAS  Google Scholar 

  42. Rünzi M, Müller MK, Schmid P, von Schönfeld J, Goebell H (1992) Stimulatory and inhibitory effects of galanin on exocrine and endocrine rat pancreas. Pancreas 7: 619–623

    Article  PubMed  Google Scholar 

  43. Saito A, Williams JA, Kanno T (1980) Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata. J Clin Invest 65: 777–782

    Article  PubMed  CAS  Google Scholar 

  44. Sarles H, Dani R, Prezelin G, et al. (1968) Cephalic phase of pancreatic secretion in man. Gut 9: 214

    Article  PubMed  CAS  Google Scholar 

  45. Schwarzendrube J, Niederau C, Lüthen R, Strohmeyer G (1991) Effects of CCK-receptor blockade on endocrine and exocrine pancreatic function in healthy humans. Gastroenterology 100: 1683–1690

    PubMed  CAS  Google Scholar 

  46. Shoratori K, Watanabe S, Takeuchi T (1989) Effect of fatty acid on secretion release and cholinergic dependence of pancreatic secretion in rats. Pancreas 4: 452–458

    Article  Google Scholar 

  47. Singer MV, Solomon TE, Grossmann MI (1980) Effect of atropine on secretion from the intact and transplanted pancreas in the dog. Am J Physiol 238: G18–G22

    PubMed  CAS  Google Scholar 

  48. Singer MV, Solomon TE, Rammert H, Caspary F, Niebel W, Goebell H, Grossman MI (1981) Effect on atropine on pancreatic response to HCI and secretin. Am J Physiol 240: G376–G380

    PubMed  CAS  Google Scholar 

  49. Solomon TE, Grossman MI (1976) Vagal control of pancreatic exocrine secretion. In: Books FP, Evers PW (eds.). Nerves and the gut. Thorofare New Jersey

    Google Scholar 

  50. Solomon TE, Grossman MI (1979) Effect of atropine and vagotomy on response of transplated pancreas. Am J Physiol 236: E186–E190

    PubMed  CAS  Google Scholar 

  51. Vagne M, Grossman MI (1969) Gastric and pancreatic secretion in response to gastric distension in dogs. Gastroenterology 57: 300

    PubMed  CAS  Google Scholar 

  52. Verspohl EJ, Ammon HPT, Williams JA, Goldfine ID (1986) Evidence that cholecystokinin interacts with specific receptors and regulates insulin release in isolated rat islets of Lan- gerhans. Diabetes 35: 38–43

    Article  PubMed  CAS  Google Scholar 

  53. Watanabe S, Chey WY, Lee KY, Chang TM (1986) Secretin is released by digestive products of fat in dogs. Gastroenterology 90: 1008

    PubMed  CAS  Google Scholar 

  54. Weihe E, Büchler M, Müller S, Friess H, Zentel HJ, Yanaihara N. (1990) Peptidergic innervation in chronic pancreatitis. In: Beger HG, Büchler M, Ditschuneit H, Malfertheiner P (Hrsg.). Chronic pancreatitis. Springer-Verlag Berlin Heidelberg 83–105

    Chapter  Google Scholar 

  55. White TT, Lundh G, Magee DF (1960) Evidence for the existence of a gastropancreatic reflex. Am J Physiol 198: 725

    PubMed  CAS  Google Scholar 

  56. White TT, McAlexander RA, Magee DF (1963) The effect of gastric distension on duodenal aspirates in man. Gastroenterology 44: 48

    PubMed  CAS  Google Scholar 

  57. You CH, Rominger JM, Chey WY (1963) Potentiation effect of cholecystokinin-octapeptide on pancreatic bicarbonate secretion stimulated by a physiological dose of secretin in humans. Gastroenterology 85: 40

    Google Scholar 

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Authors
  1. C. Niederau
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  2. T. Heintges
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  3. R. Lüthen
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Editor information

Editors and Affiliations

  1. Innere Medizin II, Medizinische Klinik und Poliklinik, Universitätskliniken des Saarlandes, 66421, Homburg/Saar, Deutschland

    Martin Zeitz

  2. Zentrum der Inneren Medizin, Universitätsklinikum, Theodor-Stem-Kai 7, 60596, Frankfurt, Deutschland

    W. F. Caspary

  3. Nationales Referenzzentrum für Enteritiserreger, Hygienisches Institut, Marckmannstraße 129a, 20539, Hamburg, Deutschland

    Jochen Bockemühl

  4. Medizinsche Klinik, Städtisches Krankenhaus Solingen, Postfach, 42719, Solingen, Deutschland

    Gerd Lux

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© 1993 Springer-Verlag Berlin Heidelberg

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Niederau, C., Heintges, T., Lüthen, R. (1993). Regulation der exokrinen Pankreassekretion. In: Zeitz, M., Caspary, W.F., Bockemühl, J., Lux, G. (eds) Ökosystem Darm V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78733-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-78733-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57591-7

  • Online ISBN: 978-3-642-78733-1

  • eBook Packages: Springer Book Archive

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