The Biologic Significance of Glycoprotein Hormone Oligosaccharides

  • J. U. Baenziger
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 22.–24. April 1993 in Mosbach/Baden book series (MOSBACH, volume 44)


The glycoprotein hormones lutropin (LH), follitropin (FSH), thyrotropin (TSH), and chorionic gonadotropin (CG) are dimeric proteins. They consist of a common a subunit and highly homologous, but hormone-specific, β subunits (Fig. 1). Even though the structures of the glycoprotein hormones are closely related at the primary, secondary, and tertiary levels, the structures of their Asn-linked oligosaccharides differ. LH and TSH bear oligosaccharides which terminate with the unique sequence SO44GalNAcβ1, 4GlcNAcβ1, 2Manα (S4GGnM) whereas FSH and CG bear oligosaccharides which terminate with the sequence sialic acid α2, 3/6Galβ1, 4GlcNAcβ1, 2Manα (Baenziger and Green 1991; Green and Baenziger 1988a, b; Green et al. 1985b; Endo et al. 1979; Mizuochi and Kobata 1980). The synthesis of these sulfated oligosaccharides reflects the activity of two highly specific enzymes, a GalNAc-transferase and a sulfotransferase.


Sialic Acid Tissue Factor Pathway Inhibitor Sulfated Oligosaccharide Tripeptide Motif Equine Chorionic Gonadotropin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. U. Baenziger
    • 1
  1. 1.Department of PathologyWashington University School of MedicineSt. LouisUSA

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