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Nucleic Acids and Molecular Biology pp 298–326Cite as

Oligonucleotide-Based Therapeutics of Human Malignancies

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 8))

Abstract

Conventional cancer therapies remain of limited use in treating the majority of common solid tumors. Patients with lung, breast, colonic, and pancreatic cancers, which cannot be surgically removed, will almost certainly develop metastatic spread of their disease and die. The treatment prospects for patients with hematologic malignancies are initially much better, but in these diseases as well, many patients are destined to suffer relapses. Confounding the issue of efficacy of treatment is the fact that standard cyto-reductive treatment modalities have the highly undesirable property of indiscriminately killing normal cells, as well as tumor cells. This leads to numerous side effects which can be extremely difficult to tolerate from the patient’s point of view and which can significantly complicate the medical management of cancer patients. Therefore, an important goal of any new anticancer therapeutic would be to greatly increase the number of tumor cells killed with minimization of normal tissue toxicity.

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Authors and Affiliations

  1. Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    M. Z. Ratajczak & A. M. Gewirtz

  2. Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    A. M. Gewirtz

Authors
  1. M. Z. Ratajczak
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  2. A. M. Gewirtz
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Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1994 Springer-Verlag Berlin Heidelberg

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Ratajczak, M.Z., Gewirtz, A.M. (1994). Oligonucleotide-Based Therapeutics of Human Malignancies. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78666-2_17

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  • DOI: https://doi.org/10.1007/978-3-642-78666-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78668-6

  • Online ISBN: 978-3-642-78666-2

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