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Structure and Function of the DNA Repair Enzyme Endonuclease III

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Book cover Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 8))

Abstract

DNA is constantly exposed to a number of agents which can cause damage to the nitrogenous bases and the phosphodiester backbone. Damage inflicted by active oxygen or ultraviolet irradiation includes a variety of altered pyrimidine lesions. These can be repaired by a base excision repair mechanism which is initiated by DNA-N-glycosylases and AP (apurinic/aptrimidinic endonucleases. This ubiquitous repair system seems to be a major defense mechanism used by all organisms (Doetsch and Cunningham 1990).

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, SUNY at Albany, Albany, NY, 12222, USA

    R. P. Cunningham

  2. Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA

    M. M. Thayer & J. A. Tainer

Authors
  1. R. P. Cunningham
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  2. M. M. Thayer
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  3. J. A. Tainer
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1994 Springer-Verlag Berlin Heidelberg

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Cunningham, R.P., Thayer, M.M., Tainer, J.A. (1994). Structure and Function of the DNA Repair Enzyme Endonuclease III. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78666-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-78666-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78668-6

  • Online ISBN: 978-3-642-78666-2

  • eBook Packages: Springer Book Archive

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